PPARγ Activation Primes Human Monocytes into Alternative M2 Macrophages with Anti-inflammatory Properties

Atherosclerosis — An Inflammatory Disease

1999 • 21,494 citations

Alternative activation of macrophages

2003 • 5,952 citations

A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation

1995 • 2,036 citations

Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation.

1992 • 1,849 citations

The PPARs: From Orphan Receptors to Drug Discovery

2000 • 1,792 citations

PPARγ Promotes Monocyte/Macrophage Differentiation and Uptake of Oxidized LDL

1998 • 1,771 citations

Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques

2007 • 1,242 citations

A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-γ

2005 • 1,189 citations

Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata

2007 • 1,183 citations

Peroxisome proliferator-activated receptors (PPARs): Nuclear receptors at the crossroads between lipid metabolism and inflammation

2000 • 929 citations

Activation of Proliferator-activated Receptors α and γ Induces Apoptosis of Human Monocyte-derived Macrophages

1998 • 914 citations

Interleukin-4-dependent production of PPAR-γ ligands in macrophages by 12/15-lipoxygenase

1999 • 835 citations

Macrophage activation switching: an asset for the resolution of inflammation

2005 • 799 citations

CLA-1/SR-BI Is Expressed in Atherosclerotic Lesion Macrophages and Regulated by Activators of Peroxisome Proliferator-Activated Receptors

2000 • 424 citations

Decoy receptors: a strategy to regulate inflammatory cytokines and chemokines

2001 • 363 citations

Classical and alternative activation of mononuclear phagocytes: Picking the best of both worlds for tumor promotion

2006 • 359 citations

Regulation of CD163 on human macrophages: cross-linking of CD163 induces signaling and activation

1999 • 220 citations

Peroxisome Proliferator-activated Receptor- as a Regulator of Lung Inflammation and Repair

2005 • 138 citations

Peroxisome proliferator-activated receptors: new targets for the pharmacological modulation of macrophage gene expression and function

2003 • 94 citations

Effect of Rosiglitazone Treatment on Plaque Inflammation and Collagen Content in Nondiabetic Patients

2006 • 67 citations

Dyslipidemia shifts the tissue factor/tissue factor pathway inhibitor balance toward increased thrombogenicity in atherosclerotic plaques

2006 • 23 citations

Inter-subject differences in constitutive expression levels of the clock gene in man

2007 • 16 citations