B Lineage–specific Regulation of V(D)J Recombinase Activity Is Established in Common Lymphoid Progenitors

RAG-1-deficient mice have no mature B and T lymphocytes

1992 • 2,859 citations

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow

1997 • 2,205 citations

RAG-1 and RAG-2, Adjacent Genes That Synergistically Activate V(D)J Recombination

1990 • 1,450 citations

The V(D)J recombination activating gene, RAG-1

1989 • 1,164 citations

Commitment to the B-lymphoid lineage depends on the transcription factor Pax5

1999 • 1,139 citations

Hairpin Opening and Overhang Processing by an Artemis/DNA-Dependent Protein Kinase Complex in Nonhomologous End Joining and V(D)J Recombination

2002 • 1,118 citations

The Mechanism and Regulation of Chromosomal V(D)J Recombination

2002 • 931 citations

Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

1996 • 657 citations

The surface phenotype of dendritic cells purified from mouse thymus and spleen: investigation of the CD8 expression by a subpopulation of dendritic cells.

1992 • 642 citations

In vivo developmental stages in murine natural killer cell maturation

2002 • 588 citations

Late embryonic lethality and impaired V (D)J recombination in mice lacking DNA ligase IV

1998 • 581 citations

Thymopoiesis independent of common lymphoid progenitors

2003 • 548 citations

DNA Transposition by the RAG1 and RAG2 Proteins

1998 • 532 citations

Transcription from the RAG1 Locus Marks the Earliest Lymphocyte Progenitors in Bone Marrow

2002 • 460 citations

The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination

1995 • 449 citations

Growth Retardation and Leaky SCID Phenotype of Ku70-Deficient Mice

1997 • 445 citations

A Targeted DNA-PKcs-Null Mutation Reveals DNA-PK-Independent Functions for KU in V(D)J Recombination

1998 • 435 citations

Dendritic cell potentials of early lymphoid and myeloid progenitors

2001 • 395 citations

Cell-fate conversion of lymphoid-committed progenitors by instructive actions of cytokines

2000 • 382 citations

Down-regulation of RAG1 and RAG2 gene expression in PreB cells after functional immunoglobulin heavy chain rearrangement

1995 • 363 citations

DNA Ligase IV Is Essential for V(D)J Recombination and DNA Double-Strand Break Repair in Human Precursor Lymphocytes

1998 • 345 citations

Identification of committed NK cell progenitors in adult murine bone marrow

2001 • 345 citations

Targeted Disruption of the Catalytic Subunit of the DNA-PK Gene in Mice Confers Severe Combined Immunodeficiency and Radiosensitivity

1998 • 323 citations

Systemic Overexpression of BCL-2 in the Hematopoietic System Protects Transgenic Mice From the Consequences of Lethal Irradiation

1998 • 299 citations

Cytotoxic/natural killer cell cutaneous lymphomas

2003 • 267 citations

Bcl-2 Rescues T Lymphopoiesis, but Not B or NK Cell Development, in Common γ Chain–Deficient Mice

1997 • 220 citations

The Lymphoid Past of Mouse Plasmacytoid Cells and Thymic Dendritic Cells

2003 • 210 citations

Regulation of V(D)J Recombination Activator Protein RAG-2 by Phosphorylation

1993 • 209 citations

A Conserved Degradation Signal Regulates RAG-2 Accumulation during Cell Division and Links V(D)J Recombination to the Cell Cycle

1996 • 199 citations

Cell cycle regulation of V(D)J recombination-activating protein RAG-2.

1994 • 184 citations

RAG2:GFP Knockin Mice Reveal Novel Aspects of RAG2 Expression in Primary and Peripheral Lymphoid Tissues

1999 • 167 citations

A Conserved Transcriptional Enhancer Regulates RAG Gene Expression in Developing B Cells

2003 • 163 citations

8 Color, 10-parameter flow cytometry to elucidate complex leukocyte heterogeneity

1997 • 160 citations

Protein Phosphatases Regulate DNA-dependent Protein Kinase Activity

2001 • 157 citations

Coordinate Regulation of RAG1 and RAG2 by Cell Type-Specific DNA Elements 5' of RAG2

1999 • 145 citations

Pax5 Determines the Identity of B Cells from the Beginning to the End of B-lymphopoiesis

2001 • 123 citations

The role of cytokine receptor signaling in lymphocyte development

1999 • 118 citations

A Common Pathway for Dendritic Cell and Early B Cell Development

2001 • 117 citations

Simultaneous fluorescence-activated cell sorter analysis of two distinct transcriptional elements within a single cell using engineered green fluorescent proteins.

1996 • 105 citations

Somatic rearrangements forming active immunoglobulin mu genes in B and T lymphoid cell lines.

1980 • 101 citations

CD19+ pro-B cells can give rise to dendritic cells in vitro.

1998 • 100 citations

In vivo transposition mediated by V(D)J recombinase in human T lymphocytes

2003 • 94 citations

Extent to which homology can constrain coding exon junctional diversity in V(D)J recombination

1993 • 90 citations

Cutting Edge: CD19+ Pro-B Cells Can Give Rise to Dendritic Cells In Vitro

1998 • 81 citations

Complementation of V(D)J Recombination Deficiency in RAG-1−/− B Cells Reveals a Requirement for Novel Elements in the N-Terminus of RAG-1

1997 • 79 citations

Regulation of V(D)J Recombination by Transcriptional Promoters

1999 • 72 citations

Murine natural killer cells do not express functional transcripts of the alpha-, beta-, or gamma-chain genes of the T cell receptor.

1986 • 72 citations

Rearrangement of IgH genes in normal thymocyte development.

1988 • 71 citations

IL-7Ralpha and E47: independent pathways required for development of multipotent lymphoid progenitors

2002 • 63 citations

Seroreactivity to an Envelope Protein of Human T-Cell Leukemia/Lymphoma Virus in Patients With CD3− (Natural Killer) Lymphoproliferative Disease of Granular Lymphocytes

1997 • 60 citations

Chapter 19: Flow Cytometric Analysis and FACS Sorting of Cells Based on GFP Accumulation

1998 • 54 citations

Lineage plasticity and commitment in T-cell development

2002 • 54 citations

RAG2is regulated differentially in B and T cells by elements 5′ of the promoter

1999 • 53 citations

Relationships between early B- and NK-lineage lymphocyte precursors in bone marrow

2002 • 52 citations

Dendritic cell origins: Puzzles and paradoxes

1999 • 41 citations

Overlapping Signals for Protein Degradation and Nuclear Localization Define a Role for Intrinsic RAG-2 Nuclear Uptake in Dividing Cells

2003 • 40 citations

Pairs of violet-light-excited fluorochromes for flow cytometric analysis

1998 • 40 citations

Multicolor-FISH analysis of a natural killer cell line (NK-92)

2002 • 38 citations

Characterization of Chromatin Structure and Enhancer Elements for Murine Recombination Activating Gene-2

2002 • 31 citations

Developmental Separation of V(D)J Recombinase Expression and Initiation of IgH Recombination in B Lineage Progenitors In Vivo

2004 • 25 citations

Novel B-cell precursors blocked at the stage of DJH recombination.

1988 • 14 citations

Novel B-Cell Precursors Blocked at the Stage of DJ_H Recombination

1988 • 4 citations