Spatially and Functionally Distinct Roles of the PI3-K Effector Pathway during NGF Signaling in Sympathetic Neurons

Cellular survival: a play in three Akts

1999 • 4,229 citations

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

1994 • 3,249 citations

Neurotrophin signal transduction in the nervous system

2000 • 1,910 citations

Requirement for Phosphatidylinositol-3 Kinase in the Prevention of Apoptosis by Nerve Growth Factor

1995 • 1,400 citations

Local control of neurite development by nerve growth factor

1977 • 732 citations

Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase.

1994 • 678 citations

The retrograde axonal transport of nerve growth factor

1974 • 598 citations

Phosphatidylinositol 3-Kinase and Akt Protein Kinase Are Necessary and Sufficient for the Survival of Nerve Growth Factor-Dependent Sympathetic Neurons

1998 • 577 citations

Signal transduction by the neutrophin receptors

1997 • 573 citations

Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase.

1996 • 560 citations

K252a is a selective inhibitor of the tyrosine protein kinase activity of the trk family of oncogenes and neurotrophin receptors.

1992 • 496 citations

Endocytosis of Activated TrkA: Evidence that Nerve Growth Factor Induces Formation of Signaling Endosomes

1996 • 434 citations

K-252a inhibits nerve growth factor-induced trk proto-oncogene tyrosine phosphorylation and kinase activity.

1992 • 368 citations

In situ immunodetection of activated caspase-3 in apoptotic neurons in the developing nervous system

1998 • 366 citations

Development of Sensory Neurons in the Absence of NGF/TrkA Signaling In Vivo

2000 • 363 citations

Phosphoinositide–Ap-2 Interactions Required for Targeting to Plasma Membrane Clathrin-Coated Pits

1999 • 304 citations

Molecular and Cellular Approaches to Neural Development

1998 • 300 citations

Disruption of PDGF Receptor Trafficking by Mutation of Its PI-3 Linase Binding Sites

1994 • 297 citations

Phospholipase C-γ and Phosphoinositide 3-Kinase Mediate Cytoplasmic Signaling in Nerve Growth Cone Guidance

1999 • 281 citations

Rapid Nuclear Responses to Target-Derived Neurotrophins Require Retrograde Transport of Ligand–Receptor Complex

1999 • 278 citations

Comparison between the retrograde axonal transport of nerve growth factor and tetanus toxin in motor, sensory and adrenergic neurons

1975 • 277 citations

Depolarization and Neurotrophins Converge on the Phosphatidylinositol 3-Kinase–Akt Pathway to Synergistically Regulate Neuronal Survival

1999 • 253 citations

Activated Phosphatidylinositol 3-Kinase and Akt Kinase Promote Survival of Superior Cervical Neurons

1997 • 245 citations

Quantitative demonstration of the retrograde axonal transport of endogenous nerve growth factor

1983 • 195 citations

A signaling organelle containing the nerve growth factor-activated receptor tyrosine kinase, TrkA

1997 • 178 citations

Essential Role of the Dynamin Pleckstrin Homology Domain in Receptor-Mediated Endocytosis

1999 • 169 citations

Phosphatidylinositol 3-Kinase Activity Is Required at a Postendocytic Step in Platelet-derived Growth Factor Receptor Trafficking

1995 • 165 citations

Ras Regulates Sympathetic Neuron Survival by Suppressing the p53-Mediated Cell Death Pathway

1999 • 150 citations

Nerve Growth Factor Modulates Synaptic Transmission between Sympathetic Neurons and Cardiac Myocytes

1997 • 141 citations

Characterization of an NGF–P-TrkA Retrograde-Signaling Complex and Age-Dependent Regulation of TrkA Phosphorylation in Sympathetic Neurons

1999 • 138 citations

Characterization of the retrograde transport of nerve growth factor (NGF) using high specific activity [125I]NGF

1978 • 131 citations

Inhibition of the cellular actions of nerve growth factor by staurosporine and K252A results from the attenuation of the activity of the trk tyrosine kinase

1992 • 129 citations

Dominant Negative Forms of Akt (Protein Kinase B) and Atypical Protein Kinase Cλ Do Not Prevent Insulin Inhibition of Phosphoenolpyruvate Carboxykinase Gene Transcription

1999 • 101 citations

Demonstration of retrogradely transported endogenous nerve growth factor in axons of sympathetic neurons

1984 • 100 citations

In sympathetic but not sensory neurones, phosphoinositide-3 kinase is important for NGF-dependent survival and the retrograde transport of 125I-βNGF

1997 • 64 citations

Phosphatidylinositol 3-Kinase Is Required for the Trophic, But Not the Survival-Promoting, Actions of NGF on Sympathetic Neurons

2000 • 43 citations

Neurotrophic factors and their receptors

1998 • 41 citations

Retrograde Transport of Endogenous Nerve Growth Factor in Superior Cervical Ganglion of Adult Rats

1987 • 41 citations

Synergistic Role of the Phosphatidylinositol 3-Kinase and Mitogen-Activated Protein Kinase Cascade in the Regulation of Insulin Receptor Trafficking*

1999 • 17 citations