No Intrinsic Deficiencies in CD8+ T Cell-Mediated Antitumor Immunity with Aging

Cancer immunoediting: from immunosurveillance to tumor escape

2002 • 4,911 citations

Counting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection

1998 • 1,996 citations

In Vivo Depletion of CD11c+ Dendritic Cells Abrogates Priming of CD8+ T Cells by Exogenous Cell-Associated Antigens

2002 • 1,734 citations

Age-related changes in lymphocyte development and function

2004 • 1,164 citations

Distinct Dendritic Cell Populations Sequentially Present Antigen to CD4 T Cells and Stimulate Different Aspects of Cell-Mediated Immunity

2003 • 702 citations

Clinical Relevance of Age-Related Immune Dysfunction

2000 • 634 citations

Cancer Survival and Incidence from the Surveillance, Epidemiology, and End Results (SEER) Program

2003 • 441 citations

Spinning molecular immunology into successful immunotherapy

2002 • 364 citations

Eradication of Established Tumors by CD8+ T Cell Adoptive Immunotherapy

2000 • 349 citations

Immunosenescence and infectious diseases

2001 • 273 citations

CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly

2003 • 256 citations

Interleukin 2, but Not Other Common γ Chain–Binding Cytokines, Can Reverse the Defect in Generation of Cd4 Effector T Cells from Naive T Cells of Aged Mice

1999 • 250 citations

Cell surface antigens of chemically induced sarcomas of the mouse. I. Murine leukemia virus-related antigens and alloantigens on cultured fibroblasts and sarcoma cells: description of a unique antigen on BALB/c Meth A sarcoma.

1977 • 231 citations

Unexpected expansions of CD8-bearing cells in old mice.

1993 • 228 citations

Unimpaired dendritic cells can be derived from monocytes in old age and can mobilize residual function in senescent T cells

2000 • 163 citations

Postthymic Development of CD28−CD8+ T Cell Subset: Age-Associated Expansion and Shift from Memory to Naive Phenotype

1999 • 156 citations

Age‐related changes in lymphokine production related to a decreased number of CD45RB^hi CD4⁺ T cells

1991 • 154 citations

Role of T cells and adherent cells in age-related decline in murine interleukin 2 production.

1982 • 153 citations

Macrophage prostaglandin production contributes to the age-associated decrease in T cell function which is reversed by the dietary antioxidant vitamin E

1997 • 152 citations

CD8 T Cells and Aging

2003 • 144 citations

Age-associated decrease in virus-specific CD8+ T lymphocytes during primary influenza infection

2002 • 140 citations

Age-Dependent Alterations in the Assembly of Signal Transduction Complexes at the Site of T Cell/APC Interaction

2000 • 135 citations

Tumour necrosis factor-α-induced migration of human Langerhans cells: the influence of ageing

2002 • 128 citations

Single-Cell Analyses Reveal Two Defects in Peptide-Specific Activation of Naive T Cells from Aged Mice

2001 • 126 citations

The frail elderly: role of dendritic cells in the susceptibility of infection

2002 • 124 citations

Defective generation but normal maintenance of memory T cells in old mice

2002 • 122 citations

From naive to effector ‐ alterations with aging

1997 • 118 citations

An age-related increase in the number of CD8+ T cells carrying receptors for an immunodominant Epstein–Barr virus (EBV) epitope is counteracted by a decreased frequency of their antigen-specific responsiveness

2003 • 112 citations

Enhanced allostimulatory activity of host antigen-presenting cells in old mice intensifies acute graft-versus-host disease

2002 • 92 citations

Enhanced allostimulatory activity of host antigen-presenting cells in old mice intensifies acute graft-versus-host disease

2002 • 82 citations

The Growth of the Very Large CD8+ T Cell Clones in Older Mice Is Controlled by Cytokines

2001 • 81 citations

Age-related impairment of human T lymphocytes’ activation: specific differences between CD4+ and CD8+ subsets

2002 • 76 citations

Genetic alterations in the ageing immune system: impact on infection and cancer

2003 • 69 citations

Efficacy of cancer gene therapy in aging: adenocarcinoma cells engineered to release IL-2 are rejected but do not induce tumor specific immune memory in old mice

2000 • 66 citations

Phenotype, antigen-presenting capacity, and migration of antigen-presenting cells in young and old age

2002 • 64 citations

Loss of tumor-specific and idiotype-specific immunity with age.

1981 • 63 citations

Defective T Cell Priming Associated with Aging Can Be Rescued by Signaling Through 4-1BB (CD137)

2002 • 57 citations

Antigen presenting cell function is enhanced in healthy elderly

1999 • 52 citations

Activated CD8+ T cells from aged mice exhibit decreased activation-induced cell death

2001 • 41 citations

Role of the thymus and T-cells in slow growth of B16 melanoma in old mice.

1987 • 40 citations

CD4-Directed Peptide Vaccination Augments an Antitumor Response, but Efficacy Is Limited by the Number of CD8+ T Cell Precursors

2004 • 33 citations

Successful elimination of large established tumors and avoidance of antigen‐loss variants by aggressive adoptive T cell immunotherapy

2003 • 33 citations

Early Antigen-Specific Response by Naive CD8 T Cells Is Not Altered with Aging

2002 • 33 citations

Rescue of the tumor-specific immune response of aged mice in vitro.

1984 • 32 citations

Tumor antigen drives a persistent oligoclonal expansion of CD8+ T cells in aged mice

2002 • 21 citations

Loss of Resistance to a Highly Immunogenic Tumor with Age Corresponds to the Decline of CD8 T Cell Activity

1998 • 17 citations

Immune Responses against Allogeneic and Syngeneic Tumors in Aged C57BL/6 Mice

2002 • 11 citations

The influence of immunosenescence on tumor growth and spread: lessons from animal models.

1991 • 5 citations