Activated CD8+ T cells from aged mice exhibit decreased activation-induced cell death

Determination of lymphocyte division by flow cytometry

1994 • 1,712 citations

Shortage of circulating naive CD8+ T cells provides new insights on immunodeficiency in aging

2000 • 515 citations

Modifications of a telomeric repeat amplification protocol (TRAP) result in increased reliability, linearity and sensitivity

1995 • 490 citations

T cell homeostasis in patients with rheumatoid arthritis

2000 • 453 citations

The use of 7-amino actinomycin D in identifying apoptosis: simplicity of use and broad spectrum of application compared with other techniques

1996 • 332 citations

Expanded CD4+ and CD8+ T cell clones in elderly humans.

1997 • 307 citations

Perturbation of the T cell repertoire in rheumatoid arthritis

1998 • 273 citations

Resistance to apoptosis in human CD8+ T cells that reach replicative senescence after multiple rounds of antigen-specific proliferation☆

1999 • 253 citations

Increased TNF-alpha-induced apoptosis in lymphocytes from aged humans: changes in TNF-alpha receptor expression and activation of caspases.

1999 • 237 citations

Increased Apoptosis of T Cell Subsets in Aging Humans: Altered Expression of Fas (CD95), Fas Ligand, Bcl-2, and Bax

1998 • 231 citations

Unexpected expansions of CD8-bearing cells in old mice.

1993 • 228 citations

Differentiation of human CD8 T cells: implications for in vivo persistence of CD8+CD28– cytotoxic effector clones

1999 • 211 citations

Apoptosis in Proliferating, Senescent, and Immortalized Keratinocytes

1999 • 209 citations

Modulation of CD28 Expression: Distinct Regulatory Pathways During Activation and Replicative Senescence

1999 • 204 citations

Increased TNF-α-Induced Apoptosis in Lymphocytes from Aged Humans: Changes in TNF-α Receptor Expression and Activation of Caspases

1999 • 174 citations

Age-related modifications of the human alphabeta T cell repertoire due to different clonal expansions in the CD4+ and CD8+ subsets

1998 • 172 citations

The Increase of IFN-γ Production through Aging Correlates with the Expanded CD8+highCD28−CD57+ Subpopulation

2000 • 166 citations

Postthymic Development of CD28−CD8+ T Cell Subset: Age-Associated Expansion and Shift from Memory to Naive Phenotype

1999 • 156 citations

Prevention of age-related T cell apoptosis defect in CD2-fas-transgenic mice.

1995 • 151 citations

Effect of aging on T lymphocyte activation

2000 • 124 citations

CD69, CD25, and HLA-DR activation antigen expression on CD3+ lymphocytes and relationship to serum TNF-α, IFN-γ, and sIL-2R levels in aging

1999 • 113 citations

Cytokine production by T lymphocytes from young and aged mice.

1996 • 99 citations

Origin of CD4-CD8-B220+ T cells in MRL-lpr/lpr mice. Clues from a T cell receptor beta transgenic mouse.

1993 • 98 citations

The IFN Regulatory Factor Family Participates in Regulation of Fas Ligand Gene Expression in T Cells

2000 • 94 citations

Gamma Interferon Modulates CD95 (Fas) and CD95 Ligand (Fas-L) Expression and Nitric Oxide-Induced Apoptosis during the Acute Phase ofTrypanosoma cruziInfection: a Possible Role in Immune Response Control

1999 • 94 citations

Increased apoptosis of CD45RO− T cells with aging

1997 • 92 citations

Stimulation of murine T cell subsets with anti-CD3 antibody. Age-related defects in the expression of early activation molecules.

1989 • 85 citations

The accumulation of non-replicative, non-functional, senescent T cells with age is avoided in calorically restricted mice by an enhancement of T cell apoptosis1This work was supported by National Institutes of Health Grant AG00424.1

1997 • 80 citations

Age-related changes in T cell surface markers: a longitudinal analysis in genetically heterogeneous mice

1997 • 76 citations

Apoptosis and ageing

1998 • 74 citations

Mechanisms of Peripheral T Cell Tolerance

2007 • 70 citations

A functional link for major TCR expansions in healthy adults caused by persistent Epstein-Barr virus infection.

1998 • 68 citations

Age-associated changes in interferon-γ and interleukin-4 secretion by purified human CD4+ and CD8+ T cells

2000 • 59 citations

Molecular and Cellular Mechanisms RegulatingTand B Cell Apoptosis through Fas/FasL Interaction

1999 • 57 citations

Age-related tyrosine-specific protein phosphorylation defect in human T lymphocytes activated through CD3, CD4, CD8 or the IL-2 receptor

1996 • 53 citations

Evidence for polyclonal T cell activation in murine models of systemic lupus erythematosus.

1994 • 47 citations

Bystander Sensitization to Activation-Induced Cell Death as a Mechanism of Virus-Induced Immune Suppression

2000 • 46 citations

Age-Related Decline in Activation of JNK by TCR- and CD28-Mediated Signals in Murine T-Lymphocytes

1999 • 45 citations

Age-associated changes in mitochondrial parameters on peripheral human lymphocytes

1999 • 44 citations

Reversal of Age-Related Deficient Influenza Virus-Specific CTL Responses and IFN-γ Production by Monophosphoryl Lipid A

1996 • 42 citations

Regulation of CD95 (APO-1) Expression and the Induction of Apoptosis in Human T Cells: Changes in Old Age

1996 • 42 citations

IL-12 enhances IL-2 function by inducing CD25 expression through a p38 mitogen-activated protein kinase pathway

2000 • 40 citations

PREVALENCE OF SELECTED AUTOANTIBODIES IN DIFFERENT ELDERLY SUBPOPULATIONS

1994 • 40 citations

Physiological T‐Cell Death: Susceptibility is Modulated by Activation, Aging, and Transformation, but the Mechanism is Constant

1994 • 39 citations

Mouse CD8+ CD122+ T Cells with Intermediate TCR Increasing with Age Provide a Source of Early IFN-γ Production

2000 • 38 citations

Down-Regulation of Ku Autoantigen, DNA-Dependent Protein Kinase, and Poly(ADP-ribose) Polymerase during Cellular Senescence

1997 • 32 citations

Corrective Effects of Interleukin-12 on Age-Related Deficiencies in IFN-gammaProduction and IL-12Rbeta2 Expression in Virus-Specific CD8⁺T Cells

2000 • 31 citations

Mechanisms of peripheral T‐cell tolerance

1997 • 30 citations

The Age-Dependent Cytokine Production by Murine CD8+ T Cells as Determined by Four-Color Flow Cytometry Analysis

1999 • 28 citations

Age-Sensitive T Cell Phenotypes Covary in Genetically Heterogeneous Mice and Predict Early Death From Lymphoma

1994 • 28 citations

Age-Related Changes of Cytokine Production by Murine Helper T Cell Subpopulations

1997 • 26 citations

Age-related changes in interferon-α/β receptor expression, binding, and induction of apoptosis in natural killer cells from C57BL/6 mice

2000 • 25 citations

Maternal Ig Mediates Neonatal Tolerance in Rheumatoid Factor Transgenic Mice but Tolerance Breaks Down in Adult Mice

1998 • 24 citations

Aged mice exhibit in vivo defective peripheral clonal deletion of Db/H-Y reactive CD8+ T cells

2001 • 18 citations

Apoptosis induced by human cytomegalovirus infection can be enhanced by cytokines to limit the spread of virus

1999 • 17 citations

Genetic differences in the age-associated decrease in inducibility of natural killer cells by interferon-α/β

2000 • 16 citations

Development of autoreactivity and changes of T cell repertoire in different strains of aging mice

1995 • 10 citations

Assessing the replicative history of human T cells

1999 • 8 citations

Increased susceptibility to apoptosis induced by anti-Fas antibody in a Rothmund-Thomson syndrome lymphoblastoid cell line.

1998 • 7 citations

Autoantibodies to T-lineage cells in aged mice

1998 • 7 citations