The Immune Regulatory Function of Lymphoproliferative Double Negative T Cells In Vitro and In Vivo

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

Suppressor Effector Function of CD4+CD25+ Immunoregulatory T Cells Is Antigen Nonspecific

2000 • 1,282 citations

Regulatory T Cells in Autoimmmunity

2000 • 1,267 citations

γδ Cells: A Right Time and a Right Place for a Conserved Third Way of Protection

2000 • 1,107 citations

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

1989 • 1,010 citations

Human Cd25+Cd4+ T Regulatory Cells Suppress Naive and Memory T Cell Proliferation and Can Be Expanded in Vitro without Loss of Function

2001 • 1,008 citations

The JAM test A simple assay for DNA fragmentation and cell death

1991 • 632 citations

Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression

2000 • 448 citations

The role of different subsets of T regulatory cells in controlling autoimmunity

2000 • 323 citations

Upregulation of Fas ligand expression by human immunodeficiency virus in human macrophages mediates apoptosis of uninfected T lymphocytes

1996 • 316 citations

Suppressor T cells – they’re back and critical for regulation of autoimmunity!

2001 • 289 citations

Pretransplantation Blood Transfusion Revisited

1991 • 220 citations

Enhanced and accelerated lymphoproliferation in Fas-null mice.

1996 • 211 citations

The lpr and gld genes in systemic autoimmunity: life and death in the Fas lane

1992 • 201 citations

The Specific Regulation Of Immune Responses By CD8⁺T Cells Restricted By The MHC Class Ib Molecule, Qa-1

2000 • 168 citations

Damage control, rather than unresponsiveness, effected by protective DX5+ T cells in autoimmune diabetes

2001 • 166 citations

Role of Antigen-Presenting Cells in Mediating Tolerance and Autoimmunity

1999 • 155 citations

Several Different Cell Surface Molecules Control Negative Selection of Medullary Thymocytes

1999 • 127 citations

The role of CD4⁺ T‐cell subsets in determining transplantation rejection or tolerance

2001 • 120 citations

Constitutive activation of the Fas ligand gene in mouse lymphoproliferative disorders.

1995 • 117 citations

TCR/Self-Antigen Interactions Drive Double-Negative T Cell Peripheral Expansion and Differentiation into Suppressor Cells

2001 • 91 citations

CD3+CD4–CD8– αβ-TCR+ T cell as immune regulatory cell

2001 • 84 citations

CD2-CD4-CD8- lymph node T lymphocytes in MRL lpr/lpr mice are derived from a CD2+CD4+CD8+ thymic precursor.

1993 • 82 citations

Mechanisms of Long-Term Donor-Specific Allograft Survival Induced by Pretransplant Infusion of Lymphocytes

1998 • 59 citations

Mechanisms of Long-Term Donor-Specific Allograft Survival Induced by Pretransplant Infusion of Lymphocytes

1998 • 48 citations

Defect in negative selection in lpr donor-derived T cells differentiating in non-lpr host thymus.

1991 • 47 citations

Ly-6A is critical for the function of double negative regulatory T cells

2002 • 45 citations

MRL/lpr CD4⁻CD8⁻ and CD8⁺ T cells, respectively, mediate Fas‐dependent and perforin cytotoxic pathways

1997 • 32 citations