Misonidazole and other hypoxia markers: Metabolism and applications

Evidence for acutely hypoxic cells in mouse tumours, and a possible mechanism of reoxygenation

1979 • 523 citations

A marker for hypoxic cells in tumours with potential clinical applicability

1981 • 309 citations

The role of catalytic superoxide formation in the O2 inhibition of nitroreductase

1975 • 306 citations

Free-Radical Intermediates in the Metabolism of Toxic Chemicals

1982 • 197 citations

Hypoxia-dependent reduction of 1-(2-nitro-1-imidazolyl)-3-methoxy-2-propanol by Chinese hamster ovary cells and KHT tumor cells in vitro and in vivo.

1976 • 195 citations

Characteristics of the metabolism-induced binding of misonidazole to hypoxic mammalian cells.

1983 • 187 citations

Binding to cellular macromolecules as a possible mechanism for the cytotoxicity of misonidazole.

1980 • 161 citations

Binding of 3H-misonidazole to solid human tumors as a measure of tumor hypoxia

1986 • 155 citations

Intracapillary oxyhemoglobin saturation of malignant tumors in humans

1981 • 131 citations

Use of Hoechst 33342 for cell selection from multicell systems.

1982 • 120 citations

The mechanisms of cytotoxicity and chemosensitization by misonidazole and other nitroimidazoles

1982 • 120 citations

Cell selection from a murine tumour using the fluorescent probe Hoechst 33342

1985 • 120 citations

Role of glutathione in the hypoxic cell cytotoxicity of misonidazole.

1983 • 119 citations

Cytotoxic Effects of the Hypoxic Cell Radiosensitizer Ro 7-0582 to Tumor Cells in Vivo

1977 • 100 citations

Biological Bases and Clinical Implications of Tumor Radioresistance

1980 • 91 citations

The labelling of EMT-6 tumours in BALB/C mice with¹⁴C-misonidazole

1983 • 80 citations

Pharmacology and toxicology of sensitizers: Mechanism studies

1984 • 80 citations

Covalent binding of a fluorinated 2-nitroimidazole to emt-6 tumors in Balb/C mice: detection by f-19 nuclear magnetic resonance at 2.35 T

1986 • 78 citations

Binding of misonidazole to hypoxic cells in monolayer and spheroid culture: Evidence that a side-chain label is bound as efficiently as a ring label

1985 • 72 citations

Binding of 14C-misonidazole to hypoxic cells in V79 spheroids

1982 • 64 citations

Metabolism induced binding of 4C-misonidazole to hypoxic cells: Kinetic dependence on oxygen concentration and misonidazole concentration

1984 • 62 citations

2-hydroxylaminoimidazoles—unstable intermediates in the reduction of 2-nitroimidazoles

1984 • 61 citations

Fluorescent nitroheterocycles for identifying hypoxic cells.

1983 • 60 citations

Glutathione conjugates of misonidazole

1983 • 60 citations

Studies on the action of nitroimidazole drugs

1983 • 59 citations

Intracellular localization of radioactively labeled misonidazole in EMT-6 tumor cells in vitro

1982 • 56 citations

Changes in misonidazole binding with hypoxic fraction in mouse tumors

1985 • 50 citations

Nitroheterocycle metabolism in mammalian cells

1984 • 48 citations

Tumour oxygenation under normobaric and hyperbaric conditions

1983 • 46 citations

Effect of oxygen on misonidazole chemosensitization and cytotoxicity in vitro.

1984 • 43 citations

Binding of misonidazole to V79 spheroids and fragments of dunning rat prostatic and human colon carcinomas in vitro: Diffusion of oxygen and reactive metabolites

1984 • 42 citations

Reductive fragmentation of 2-nitroimidazoles in the presence of nitroreductases—glyoxal formation from misonidazole

1983 • 42 citations

Oxygen Tension, Cellular Respiration, and Redox State as Variables Influencing the Cytotoxicity of the Radiosensitizer Misonidazole

1982 • 41 citations

Pharmacokinetics of hypoxic cell radiosensitizers: a review.

1980 • 41 citations

Clinical trials with hypoxic cell sensitizers: Time to retrench or time to push forward?

1984 • 41 citations

Regional [14C]misonidazole distribution in experimental RT-9 brain tumors.

1983 • 39 citations

Synthesis and In vivo studies of the radiosensitizer 4-[82Br]bromomisonidazole

1983 • 37 citations

Kryomicrophotometry as a Method for Analyzing the Intracapillary HbO2 Saturation of Organs Under Different O2 Supply Conditions

1976 • 33 citations

Detection of a Reactive Metabolite of Misonidazole in Hypoxic Mammalian Cells

1984 • 33 citations

Activation of radiosensitizers by hypoxic cells.

1978 • 32 citations

Binding of misonidazole to EMT6 AND V79 spheroids

1982 • 32 citations

Regional measurements of [14C]misonidazole distribution and blood flow in subcutaneous RT-9 experimental tumors.

1985 • 30 citations

Misonidazole-glutathione conjugates in CHO cells

1984 • 30 citations

Comparison of Binding of [ 3 H]Misonidazole and [ 14 C]Misonidazole in Multicell Spheroids

1985 • 28 citations

Reductive fragmentation of 2-nitroimidazoles: Amines and aldehydes

1984 • 28 citations

Fluorescent markers for hypoxic cells: a comparison of two compounds on three cell lines

1985 • 27 citations

Comparative misonidazole metabolism in anaerobic bacteria and hypoxic Chinese hamster lung fibroblast (V-79-473) cells

1982 • 26 citations

Influence of hypoxia on the metabolism and excretion of misonidazole by the isolated perfused rat liver—A model system

1983 • 25 citations

Hypoxic Fraction and Binding of Misonidazole in EMT6/Ed Multicellular Tumor Spheroids

1985 • 24 citations

Metabolism and excretion of [3H]misonidazole by hypoxic rat liver

1984 • 24 citations

Bromomisonidazole: Synthesis and Characterization of a New Radiosensitizer

1982 • 24 citations

Evidence suggesting that the mechanism for aerobic and hypoxic cytotoxicity of nitroheterocycles is the same

1982 • 22 citations

Further Characterization of 4-Bromomisonidazole as a Potential Detector of Hypoxic Cells

1985 • 22 citations

Nitroakridin 3582: a fluorescent nitroacridine stain for identifying hypoxic cells

1983 • 19 citations

Cellular metabolism of fluorescent nitroheterocycles

1984 • 18 citations

Decreased hypoxic toxicity and binding of misonidazole by low glucose concentration

1986 • 15 citations

Detection of a reactive metabolite of misonidazole in human urine

1984 • 14 citations

Uptake and mutagenicity of AF‐2 in chinese hamster V‐79 spheroids under aerobic and hypoxic conditions

1981 • 13 citations

Electron-affinic compounds for labelling hypoxic cells: the synthesis and characterization of 1-[2-(2-iodophenoxy)-ethyl]-2-nitroimidazole.

1984 • 13 citations

The cellular basis of radiotherapeutic response

1984 • 12 citations

Electron-Affillic Compounds for Labelling Hypoxie Cells : The Synthesis and Characterization of 1-[2-(2-Iodophenoxy)-Ethyl]-2-Nitroimidazole

1984 • 11 citations

Misonidazole retention by normal tissues: a distinction between label on the ring and side chain

1986 • 11 citations

Comparative distribution of misonidazole and its amine metabolite in female swiss webster mice

1985 • 3 citations