Mapping of the p53 and mdm-2 Interaction Domains

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1988 • 6,107 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

1990 • 3,720 citations

Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins

1989 • 3,219 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53

1990 • 2,587 citations

T antigen is bound to a host protein in SY40-transformed cells

1979 • 2,378 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

Amplification of a gene encoding a p53-associated protein in human sarcomas

1992 • 1,959 citations

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

1992 • 1,877 citations

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

1979 • 1,830 citations

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1992 • 1,358 citations

Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li–Fraumeni syndrome

1990 • 1,228 citations

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles

1992 • 1,117 citations

Monoclonal antibodies specific for simian virus 40 tumor antigens

1981 • 1,110 citations

Identification of p53 as a Sequence-Specific DNA-Binding Protein

1991 • 1,109 citations

Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells

1982 • 883 citations

Wild-type p53 can inhibit oncogene-mediated focus formation.

1989 • 738 citations

Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line.

1991 • 712 citations

Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation

1991 • 617 citations

A structural taxonomy of DNA-binding domains

1991 • 615 citations

Wild-type p53 activates transcription in vitro

1992 • 609 citations

Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein

1992 • 567 citations

Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein.

1991 • 544 citations

The transcriptional transactivation function of wild-type p53 is inhibited by SV40 large T-antigen and by HPV-16 E6 oncoprotein.

1992 • 375 citations

Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line

1987 • 357 citations

Oncogenic Forms of p53 Inhibit p53-Regulated Gene Expression

1992 • 333 citations

Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element.

1992 • 328 citations

p53: a transdominant regulator of transcription whose function is ablated by mutations occurring in human cancer.

1992 • 278 citations

Site-specific binding of wild-type p53 to cellular DNA is inhibited by SV40 T antigen and mutant p53.

1992 • 230 citations

Domains required for in vitro association between the cellular p53 and the adenovirus 2 E1B 55k proteins

1990 • 207 citations

The p53 protein and its interactions with the oncogene products of the small DNA tumor viruses

1990 • 200 citations

Identification of the p53 protein domain involved in formation of the simian virus 40 large T-antigen-p53 protein complex

1986 • 175 citations

Two distinct regions of the murine p53 primary amino acid sequence are implicated in stable complex formation with simian virus 40 T antigen

1988 • 92 citations