Fission yeast cdc21, a member of the MCM protein family, is required for onset of S phase and is located in the nucleus throughout the cell cycle.

Transformation of intact yeast cells treated with alkali cations

1983 • 7,688 citations

[56] Molecular genetic analysis of fission yeast Schizosaccharomyces pombe

1991 • 3,691 citations

[12] One-step gene disruption in yeast

1983 • 3,302 citations

Checkpoints: Controls That Ensure the Order of Cell Cycle Events

1989 • 3,036 citations

Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: Identification of a class of bipartite nuclear targeting sequence

1991 • 1,501 citations

ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex

1992 • 1,279 citations

Genetic Approach to Facilitate Purification of Recombinant Proteins with a Novel Metal Chelate Adsorbent

1988 • 1,030 citations

Thiamine-repressible expression vectors pREP and pRIP for fission yeast

1993 • 1,013 citations

nmt1 of fission yeast. A highly transcribed gene completely repressed by thiamine.

1990 • 859 citations

Structural rearrangements of tubulin and actin during the cell cycle of the yeast Saccharomyces.

1984 • 827 citations

Mammalian Cell Fusion : Studies on the Regulation of DNA Synthesis and Mitosis

1970 • 759 citations

Definition of individual components within the cytoskeleton of Trypanosoma brucei by a library of monoclonal antibodies

1989 • 650 citations

A role for the nuclear envelope in controlling DNA replication within the cell cycle

1988 • 605 citations

A checkpoint regulates the rate of progression through S phase in S. cerevisiae in Response to DNA damage

1995 • 596 citations

Regulation of p34cdc2 protein kinase during mitosis

1989 • 544 citations

The Units of DNA Replication in Drosophila melanogaster Chromosomes

1974 • 518 citations

The use of cell division cycle mutants to investigate the control of microtubule distribution in the fission yeast Schizosaccharomyces pombe

1988 • 493 citations

Mutation of fission yeast cell cycle control genes abolishes dependence of mitosis on DNA replication

1990 • 460 citations

The fission yeast cdc18+ gene product couples S phase to START and mitosis

1993 • 446 citations

Comparison ofSchizosaccharomyces pombeexpression systems

1993 • 439 citations

Yeast Origin Recognition Complex Functions in Transcription Silencing and DNA Replication

1993 • 435 citations

DNA repair mutants defining G2 checkpoint pathways in Schizosaccharomyces pombe.

1992 • 417 citations

Isolation of ORC6 , a Component of the Yeast Origin Recognition Complex by a One-Hybrid System

1993 • 416 citations

DNA polymerase ϵ links the DNA replication machinery to the S phase checkpoint

1995 • 411 citations

A common set of conserved motifs in a vast variety of putative nucleic acid-dependent ATPases including MCM proteins involved in the initiation of eukaryotic DNA replication

1993 • 400 citations

Protein-DNA interactions at a yeast replication origin

1992 • 380 citations

Purification of an MCM-containing complex as a component of the DNA replication licensing system

1995 • 361 citations

A group of interacting yeast DNA replication genes.

1991 • 325 citations

Cell division cycle mutants altered in DNA replication and mitosis in the fission yeast Schizosaccharomyces pombe

1981 • 309 citations

Identification of the yeast MCM3-related protein as a component of xenopus DNA replication licensing factor

1995 • 280 citations

Mitochondrial growth and DNA synthesis occur in the absence of nuclear DNA replication in fission yeast

1990 • 266 citations

Cell cycle arrest of cdc mutants and specificity of the RAD9 checkpoint.

1993 • 263 citations

System for High-Level Production in Escherichia coli and Rapid Purification of Recombinant Proteins: Application to Epitope Mapping, Preparation of Antibodies, and Structure—Function Analysis

1990 • 261 citations

BM28, a human member of the MCM2-3-5 family, is displaced from chromatin during DNA replication.

1995 • 234 citations

Cell cycle-regulated nuclear localization of MCM2 and MCM3, which are required for the initiation of DNA synthesis at chromosomal replication origins in yeast.

1993 • 233 citations

cdt1 is an essential target of the Cdc10/Sct1 transcription factor: requirement for DNA replication and inhibition of mitosis.

1994 • 232 citations

Fission yeast cut5+, required for S phase onset and M phase restraint, is identical to the radiation-damage repair gene rad4+

1993 • 231 citations

Subcellular localization of yeast CDC46 varies with the cell cycle.

1990 • 226 citations

Checkpoint controls in Schizosaccharomyces pombe: rad1.

1992 • 224 citations

Fission yeast minichromosome loss mutants mis cause lethal aneuploidy and replication abnormality.

1994 • 211 citations

Nuclear export of proteins: The role of nuclear retention

1993 • 209 citations

Mcm2 and Mcm3, two proteins important for ARS activity, are related in structure and function.

1991 • 196 citations

DNA polymerase alpha associated protein P1, a murine homolog of yeast MCM3, changes its intranuclear distribution during the DNA synthetic period.

1994 • 173 citations

The nuclear membrane prevents replication of human G2 nuclei but not G1 nuclei in Xenopus egg extract

1992 • 140 citations

Cell cycle-regulated nuclear import and export of Cdc47, a protein essential for initiation of DNA replication in budding yeast.

1995 • 140 citations

The phenotype of the minichromosome maintenance mutant mcm3 is characteristic of mutants defective in DNA replication.

1990 • 138 citations

Properties of the nuclear P1 protein, a mammalian homologue of the yeast Mcm3 replication protein

1992 • 137 citations

Fission yeastcdc21⁺belongs to a family of proteins involved in an early step of chromosome replication

1992 • 131 citations

Isolation and analysis of the fission yeast gene encoding polymerase delta accessory protein PCNA.

1992 • 125 citations

The MCM2-3-5 proteins: are they replication licensing factors?

1994 • 124 citations

A human nuclear protein with sequence homology to a family of early s phase proteins is required for entry into s phase and for cell division

1994 • 120 citations

DNA polymerase alpha, a component of the replication initiation complex, is essential for the checkpoint coupling S phase to mitosis in fission yeast

1995 • 118 citations

Feedback controls and G2 checkpoints: Fission yeast as a model system

1993 • 113 citations

CDC46/MCM5, a yeast protein whose subcellular localization is cell cycle-regulated, is involved in DNA replication at autonomously replicating sequences.

1992 • 99 citations

A Human Homologue of the Yeast Replication Protein Cdc21. Interactions with Other Mcm Proteins

1995 • 87 citations

The P1 family: a new class of nuclear mammalian proteins related to the yeast Mem replication proteins

1993 • 87 citations

Reversible effects of nuclear membrane permeabilization on DNA replication: evidence for a positive licensing factor

1993 • 83 citations

The fission yeast cdc19+ gene encodes a member of the MCM family of replication proteins

1994 • 78 citations

Fission yeast genes nda1+ and nda4+, mutations of which lead to S-phase block, chromatin alteration and Ca2+ suppression, are members of the CDC46/MCM2 family.

1993 • 78 citations

Expression, phosphorylation and nuclear localization of the human P1 protein, a homologue of the yeast Mcm 3 replication protein

1995 • 59 citations

DNA replication in cell-free extracts from Drosophila melanogaster.

1991 • 58 citations

The Phenotype of the Minichromosome Maintenance Mutant mcm3 Is Characteristic of Mutants Defective in DNA Replication

1990 • 47 citations

REGULATION OF DNA REPLICATION IN THE NUCLEI OF THE SLIME MOLD PHYSARUM POLYCEPHALUM

1968 • 41 citations

Cdc54 belongs to the Cdc46/Mcm3 family of proteins which are essential for initiation of eukaryotic DNA replication

1995 • 41 citations

MCM3 complex required for cell cycle regulation of DNA replication in vertebrate cells

1995 • 13 citations

The mcm2-1 mutation of yeast causes DNA damage with a RAD9 requirement for repair

1995 • 6 citations