Nitric oxide and coronary endothelial dysfunction in humans

Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.

1996 • 2,456 citations

Regression of Coronary Artery Disease as a Result of Intensive Lipid-Lowering Therapy in Men with High Levels of Apolipoprotein B

1990 • 2,192 citations

Close relation of endothelial function in the human coronary and peripheral circulations

1995 • 2,061 citations

Upregulation of Endothelial Nitric Oxide Synthase by HMG CoA Reductase Inhibitors

1998 • 1,860 citations

Nitric Oxide Is Responsible for Flow-Dependent Dilatation of Human Peripheral Conduit Arteries In Vivo

1995 • 1,632 citations

EFFECTS OF ENDOTHELIUM-DERIVED NITRIC OXIDE ON PERIPHERAL ARTERIOLAR TONE IN MAN

1989 • 1,625 citations

Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease.

1990 • 1,190 citations

The Effect of Cholesterol-Lowering and Antioxidant Therapy on Endothelium-Dependent Coronary Vasomotion

1995 • 1,123 citations

Reductions in Arterial Diameter Produced by Chronic Decreases in Blood Flow Are Endothelium-Dependent

1986 • 1,106 citations

Beneficial Effects of Cholesterol-Lowering Therapy on the Coronary Endothelium in Patients with Coronary Artery Disease

1996 • 1,066 citations

Angiotensin-Converting Enzyme Inhibition With Quinapril Improves Endothelial Vasomotor Dysfunction in Patients With Coronary Artery Disease

1996 • 1,065 citations

Modulation of coronary vasomotor tone in humans. Progressive endothelial dysfunction with different early stages of coronary atherosclerosis.

1991 • 1,010 citations

Circulating and Tissue Endothelin Immunoreactivity in Advanced Atherosclerosis

1991 • 967 citations

L-arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans.

1992 • 822 citations

Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine

1991 • 813 citations

Endothelium-mediated coronary blood flow modulation in humans. Effects of age, atherosclerosis, hypercholesterolemia, and hypertension.

1993 • 685 citations

Plasma high density lipoproteins. Metabolism and relationship to atherogenesis.

1990 • 660 citations

Physical Training Improves Endothelial Function in Patients With Chronic Heart Failure

1996 • 638 citations

The Effect of Atherosclerosis on the Vasomotor Response of Coronary Arteries to Mental Stress

1991 • 602 citations

Reduction in serum cholesterol with pravastatin improves endothelium-dependent coronary vasomotion in patients with hypercholesterolemia.

1994 • 602 citations

Plasma High-Density Lipoproteins

1978 • 504 citations

Native Low-Density Lipoprotein Increases Endothelial Cell Nitric Oxide Synthase Generation of Superoxide Anion

1995 • 479 citations

Beneficial effect of cholesterol-lowering therapy on coronary endothelium-dependent relaxation in hypercholesterolaemic patients

1993 • 462 citations

Evidence that selective endothelial dysfunction may occur in the absence of angiographic or ultrasound atherosclerosis in patients with risk factors for atherosclerosis

1994 • 457 citations

Nitric oxide activity in the human coronary circulation. Impact of risk factors for coronary atherosclerosis.

1995 • 455 citations

A Caveolar Complex between the Cationic Amino Acid Transporter 1 and Endothelial Nitric-oxide Synthase May Explain the “Arginine Paradox”

1997 • 450 citations

HMG-CoA Reductase Inhibitors Decrease CD11b Expression and CD11b-Dependent Adhesion of Monocytes to Endothelium and Reduce Increased Adhesiveness of Monocytes Isolated From Patients With Hypercholesterolemia

1997 • 423 citations

Divergent Effects of Serotonin on Coronary-Artery Dimensions and Blood Flow in Patients with Coronary Atherosclerosis and Control Patients

1991 • 420 citations

Cigarette Smoking Potentiates Endothelial Dysfunction of Forearm Resistance Vessels in Patients With Hypercholesterolemia

1996 • 411 citations

Vasoconstriction of stenotic coronary arteries during dynamic exercise in patients with classic angina pectoris: reversibility by nitroglycerin.

1986 • 371 citations

Atherosclerosis influences the vasomotor response of epicardial coronary arteries to exercise.

1989 • 368 citations

Endothelin in Coronary Endothelial Dysfunction and Early Atherosclerosis in Humans

1995 • 358 citations

Coronary vasomotion in response to sympathetic stimulation in humans: Importance of the functional integrity of the endothelium

1989 • 346 citations

Short-term cholesterol lowering decreases size and severity of perfusion abnormalities by positron emission tomography after dipyridamole in patients with coronary artery disease. A potential noninvasive marker of healing coronary endothelium.

1994 • 338 citations

Flow-dependent coronary artery dilatation in humans.

1989 • 333 citations

Role of Bradykinin in Mediating Vascular Effects of Angiotensin-Converting Enzyme Inhibitors in Humans

1997 • 332 citations

Oxidized low density lipoproteins inhibit relaxations of porcine coronary arteries. Role of scavenger receptor and endothelium-derived nitric oxide.

1991 • 331 citations

Responses of angiographically normal human coronary arteries to intracoronary injection of acetylcholine by age and segment. Possible role of early coronary atherosclerosis.

1990 • 324 citations

Endothelial dysfunction: Clinical implications

1997 • 305 citations

Vitamin C Improves Endothelial Dysfunction of Epicardial Coronary Arteries in Hypertensive Patients

1997 • 288 citations

Coronary atherosclerotic wall thickening and vascular reactivity in humans. Elevated high-density lipoprotein levels ameliorate abnormal vasoconstriction in early atherosclerosis.

1994 • 264 citations

Endothelium-Dependent Dilatation Is Impaired in Young Healthy Subjects With a Family History of Premature Coronary Disease

1997 • 257 citations

Low basal and stimulated release of nitric oxide in atherosclerotic epicardial coronary arteries

1990 • 244 citations

EDRF-mediated shear-induced dilation opposes myogenic vasoconstriction in small rabbit arteries

1991 • 239 citations

Pathophysiological consequences of atherosclerosis extend into the coronary microcirculation. Restoration of endothelium-dependent responses by L-arginine.

1992 • 230 citations

Effect of Cholesterol Reduction on Myocardial Ischemia in Patients With Coronary Disease

1997 • 221 citations

Patients with evidence of coronary endothelial dysfunction as assessed by acetylcholine infusion demonstrate marked increase in sensitivity to constrictor effects of catecholamines.

1992 • 214 citations

Role of Endogenous Bradykinin in Human Coronary Vasomotor Control

1995 • 207 citations

Transcardiac serotonin concentration is increased in selected patients with limiting angina and complex coronary lesion morphology.

1989 • 202 citations

Endothelium-Dependent Coronary Vasomotion Relates to the Susceptibility of LDL to Oxidation in Humans

1996 • 199 citations

Glutathione-Related Antioxidant Defenses in Human Atherosclerotic Plaques

1998 • 193 citations

Reduction of Transient Myocardial Ischemia With Pravastatin in Addition to the Conventional Treatment in Patients With Angina Pectoris

1996 • 164 citations

Ramiprilat increases bradykinin outflow from isolated hearts of rat

1993 • 150 citations

Differential Effects of Quinaprilat and Enalaprilat on Endothelial Function of Conduit Arteries in Patients With Chronic Heart Failure

1998 • 147 citations

L-2-Oxothiazolidine-4-carboxylic acid reverses endothelial dysfunction in patients with coronary artery disease.

1998 • 141 citations

Effects of Short-Term Treatment of Hyperlipidemia on Coronary Vasodilator Function and Myocardial Perfusion in Regions Having Substantial Impairment of Baseline Dilator Reverse

1998 • 135 citations

Endothelial function in human coronary arteries in vivo. Focus on hypercholesterolemia.

1991 • 133 citations

Effect of vitamin E on endothelial vasodilator function in patients with hypercholesterolemia, chronic smoking or both

1999 • 123 citations

Angiographically silent atherosclerosis detected by intravascular ultrasound in patients with familial hypercholesterolemia and familial combined hyperlipidemia: Correlation with high density lipoproteins

1996 • 107 citations

Intracoronary Infusion of Reduced Glutathione Improves Endothelial Vasomotor Response to Acetylcholine in Human Coronary Circulation

1998 • 102 citations

Effect of Atherosclerosis on Endothelium-Dependent Inhibition of Platelet Activation in Humans

1998 • 93 citations

Low Plasma Ascorbic Acid Independently Predicts the Presence of an Unstable Coronary Syndrome

1998 • 86 citations

Effects of neutral endopeptidase inhibition and combined angiotensin converting enzyme and neutral endopeptidase inhibition on angiotensin and bradykinin peptides in rats.

1998 • 66 citations

High-Affinity Arginine Transport of Bovine Aortic Endothelial Cells Is Impaired by Lysophosphatidylcholine

1998 • 64 citations

Vasoconstrictor activity of coronary sinus plasma from patients with coronary artery disease

1987 • 56 citations

Functional Evaluation of Lipid-Lowering Therapy by Pravastatin in the Regression Growth Evaluation Statin Study (REGRESS)

1997 • 51 citations

Modulation of vascular tone by low density lipoproteins: effects on L‐arginine transport and nitric oxide synthesis

1997 • 50 citations

Clinical morbidities in subjects with doppler-evaluated endothelial dysfunction of coronary artery

1998 • 21 citations

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