STI-571: an anticancer protein-tyrosine kinase inhibitor

The Hallmarks of Cancer

2000 • 27,569 citations

The Protein Kinase Complement of the Human Genome

2002 • 7,708 citations

MOLMOL: A program for display and analysis of macromolecular structures

1996 • 7,169 citations

Initial sequencing and comparative analysis of the mouse genome

2002 • 6,971 citations

Efficacy and Safety of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in Chronic Myeloid Leukemia

2001 • 5,189 citations

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

Efficacy and Safety of Imatinib Mesylate in Advanced Gastrointestinal Stromal Tumors

2002 • 4,254 citations

A New Consistent Chromosomal Abnormality in Chronic Myelogenous Leukaemia identified by Quinacrine Fluorescence and Giemsa Staining

1973 • 4,217 citations

Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr–Abl positive cells

1996 • 3,649 citations

Oncogenic kinase signalling

2001 • 3,632 citations

Activity of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in the Blast Crisis of Chronic Myeloid Leukemia and Acute Lymphoblastic Leukemia with the Philadelphia Chromosome

2001 • 2,749 citations

Transforming gene product of Rous sarcoma virus phosphorylates tyrosine

1980 • 2,387 citations

A minute chromosome in human chronic granulocytic leukemia

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Induction of Chronic Myelogenous Leukemia in Mice by the P210 ^bcr/abl Gene of the Philadelphia Chromosome

1990 • 2,207 citations

Protein kinases — the major drug targets of the twenty-first century?

2002 • 2,101 citations

Structural Mechanism for STI-571 Inhibition of Abelson Tyrosine Kinase

2000 • 1,770 citations

The Conformational Plasticity of Protein Kinases

2002 • 1,691 citations

Fused transcript of abl and bcr genes in chronic myelogenous leukaemia

1985 • 1,650 citations

Chronic Myeloid Leukemia

1999 • 1,639 citations

A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia

1982 • 1,385 citations

Active and Inactive Protein Kinases: Structural Basis for Regulation

1996 • 1,361 citations

Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug

2002 • 1,349 citations

Protein Tyrosine Kinase Structure and Function

2000 • 1,117 citations

The origins of protein phosphorylation

2002 • 1,047 citations

Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571).

2002 • 925 citations

An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity

1984 • 913 citations

Lessons learned from the development of an Abl tyrosine kinase inhibitor for chronic myelogenous leukemia

2000 • 897 citations

Structural Basis for the Autoinhibition of c-Abl Tyrosine Kinase

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The Chronic Myelogenous Leukemia-Specific P210 Protein Is the Product of the bcr / abl Hybrid Gene

1986 • 820 citations

Abelson murine leukaemia virus protein is phosphorylated in vitro to form phosphotyrosine

1980 • 539 citations

Induction of a chronic myelogenous leukemia-like syndrome in mice with v-abl and BCR/ABL.

1990 • 535 citations

Philadelphia ChromosomePositive Leukemias: From Basic Mechanisms to Molecular Therapeutics

2003 • 352 citations

Several Bcr-Abl kinase domain mutants associated with imatinib mesylate resistance remain sensitive to imatinib

2003 • 321 citations

The Abl family kinases: Mechanisms of regulation and signaling

2002 • 294 citations

c-Abl Has High Intrinsic Tyrosine Kinase Activity That Is Stimulated by Mutation of the Src Homology 3 Domain and by Autophosphorylation at Two Distinct Regulatory Tyrosines

2000 • 270 citations

Detection of c-abl tyrosine kinase activity in vitro permits direct comparison of normal and altered abl gene products.

1985 • 266 citations

How do protein kinases discriminate between serine/threonine and tyrosine? Structural insights from the insulin receptor protein‐tyrosine kinase

1995 • 187 citations

Variation on an Src-like Theme

2003 • 183 citations

Imatinib (STI571) Resistance in Chronic Myelogenous Leukemia: Molecular Basis of the Underlying Mechanisms and Potential Strategies for Treatment

2004 • 167 citations

Adenosine cyclic 3',5'-monophosphate dependent protein kinase: a new fluorescence displacement titration technique for characterizing the nucleotide binding site on the catalytic subunit

1983 • 75 citations

Activation of c-Abl Kinase Activity and Transformation by a Chemical Inducer of Dimerization

2001 • 47 citations

A Coiled-coil Tetramerization Domain of BCR-ABL Is Essential for the Interactions of SH2-containing Signal Transduction Molecules

1997 • 32 citations

Philadelphia-positive leukemia: a personal perspective

2002 • 21 citations