The tyrosine kinase Lck is required for CD95-independent caspase-8 activation and apoptosis in response to ionizing radiation

Caspases: Enemies Within

1998 • 6,923 citations

Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

1998 • 4,383 citations

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

1998 • 3,603 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

1995 • 2,436 citations

Caspases: Intracellular Signaling by Proteolysis

1997 • 2,114 citations

Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9

1998 • 1,642 citations

A novel form of Epstein-Barr virus latency in normal B cells in vivo

1995 • 1,552 citations

Differential Requirement for Caspase 9 in Apoptotic Pathways In Vivo

1998 • 1,292 citations

Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

1992 • 1,046 citations

Involvement of the CD95 (APO–1/Fas) receptor/ligand system in drug–induced apoptosis in leukemia cells

1996 • 1,001 citations

Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c

1998 • 872 citations

The Overexpression of Bax Produces Cell Death upon Induction of the Mitochondrial Permeability Transition

1998 • 588 citations

Bcl-X _L interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation

1998 • 534 citations

Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade

1998 • 531 citations

Radiation-induced apoptosis: Relevance to radiotherapy

1995 • 504 citations

Caspases Are Activated in a Branched Protease Cascade and Control Distinct Downstream Processes in Fas-induced Apoptosis

1998 • 450 citations

Lck Regulates Vav Activation of Members of the Rho Family of GTPases

1997 • 305 citations

Solution Structure of the RAIDD CARD and Model for CARD/CARD Interaction in Caspase-2 and Caspase-9 Recruitment

1998 • 302 citations

Comparison of Apoptosis in Wild-Type and Fas-Resistant Cells: Chemotherapy-Induced Apoptosis Is Not Dependent on Fas/Fas Ligand Interactions

1997 • 262 citations

T Cells Deficient in Inositol 1,4,5-Trisphosphate Receptor Are Resistant to Apoptosis

1997 • 259 citations

Differential Regulation and ATP Requirement for Caspase-8 and Caspase-3 Activation during CD95- and Anticancer Drug–induced Apoptosis

1998 • 213 citations

Tyrosine kinase-dependent activation of a chloride channel in CD95-induced apoptosis in T lymphocytes

1998 • 200 citations

Cross-Resistance of CD95- and Drug-Induced Apoptosis as a Consequence of Deficient Activation of Caspases (ICE/Ced-3 Proteases)

1997 • 198 citations

Role of Reactive Oxygen Intermediates in Activation-induced CD95 (APO-1/Fas) Ligand Expression

1998 • 193 citations

Ceramide-induced inhibition of T lymphocyte voltage-gated potassium channel is mediated by tyrosine kinases

1997 • 188 citations

Tyrosine kinase activation provides an early and requisite signal for Fas-induced apoptosis.

1994 • 184 citations

Drug-induced apoptosis is associated with enhanced Fas (Apo-1/CD95) ligand expression but occurs independently of Fas (Apo-1/CD95) signaling in human T-acute lymphatic leukemia cells.

1997 • 183 citations

Fas/Fas Ligand Interaction Contributes to UV-Induced Apoptosis in Human Keratinocytes

1997 • 183 citations

Overexpression of bax sensitizes human breast cancer MCF-7 cells to radiation-induced apoptosis

1996 • 170 citations

Regulation of CD95 (Fas) ligand expression by TCR-mediated signaling events.

1997 • 167 citations

BTK as a Mediator of Radiation-Induced Apoptosis in DT-40 Lymphoma B Cells

1996 • 166 citations

Fas ligation induces apoptosis and Jun kinase activation independently of CD45 and Lck in human T cells

1996 • 127 citations

Radiation-Induced Apoptosis in Human Lymphocytes and Lymphoma Cells Critically Relies on the Up-Regulation of CD95/Fas/APO-1 Ligand

1998 • 92 citations

Regulation of the Lck SH2 Domain by Tyrosine Phosphorylation

1996 • 86 citations

Increasing the susceptibility of the rat 208F fibroblast cell line to radiation-induced apoptosis does not alter its clonogenic survival dose-response

1995 • 68 citations

Distinctive Functions of Syk and Lyn in Mediating Osmotic Stress- and Ultraviolet C Irradiation-induced Apoptosis in Chicken B Cells

1997 • 65 citations

Paxillin Phosphorylation and Association with Lck and Pyk2 in Anti-CD3- or Anti-CD45-stimulated T Cells

1998 • 65 citations

Modification of Phosphatidylinositol 3-Kinase SH2 Domain Binding Properties by Abl- or Lck-mediated Tyrosine Phosphorylation at Tyr-688

1998 • 58 citations

Activation of Src-family tyrosine kinases during Fas-induced apoptosis

1996 • 57 citations

Temporal Phases in Apoptosis Defined by the Actions of Src Homology 2 Domains, Ceramide, Bcl-2, Interleukin-1β Converting Enzyme Family Proteases, and a Dense Membrane Fraction

1997 • 40 citations

Engagement of the CD19 Receptor on Human B-Lineage Leukemia Cells Activates LCK Tyrosine Kinase and Facilitates Radiation-Induced Apoptosis

1993 • 37 citations