New Methods for Assessing T-Cell Responses

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

1999 • 5,659 citations

Phenotypic Analysis of Antigen-Specific T Lymphocytes

1996 • 3,611 citations

Counting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection

1998 • 1,996 citations

Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma

1998 • 1,826 citations

Analysis of Successful Immune Responses in Persons Infected with Hepatitis C Virus

2000 • 1,270 citations

Vaccination with Mage-3a1 Peptide–Pulsed Mature, Monocyte-Derived Dendritic Cells Expands Specific Cytotoxic T Cells and Induces Regression of Some Metastases in Advanced Stage IV Melanoma

1999 • 1,260 citations

Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients

1999 • 1,131 citations

Detection of intracellular cytokines by flow cytometry

1993 • 992 citations

Direct Visualization of Antigen-specific CD8+T Cells during the Primary Immune Response to Epstein-Barr Virus In Vivo

1998 • 902 citations

Human tumor antigens recognized by T lymphocytes.

1996 • 860 citations

Tumor regressions observed in patients with metastatic melanoma treated with an antigenic peptide encoded by geneMAGE-3 and presented by HLA-A1

1999 • 803 citations

Induction of a CD8+ Cytotoxic T Lymphocyte Response by Cross-priming Requires Cognate CD4+ T Cell Help

1997 • 729 citations

The role of CD4+ T cell responses in antitumor immunity

1998 • 678 citations

Cytotoxic T cells recognize fragments of the influenza nucleoprotein

1985 • 669 citations

Regression of human metastatic renal cell carcinoma after vaccination with tumor cell–dendritic cell hybrids

2000 • 652 citations

A New Era for Cancer Immunotherapy Based on the Genes that Encode Cancer Antigens

1999 • 578 citations

T-cell repertoire diversity and clonal expansions in normal and clinical samples

1995 • 562 citations

Phenotypic analysis of antigen-specific T lymphocytes. Science. 1996. 274: 94-96.

2011 • 539 citations

Ex Vivo Staining of Metastatic Lymph Nodes by Class I Major Histocompatibility Complex Tetramers Reveals High Numbers of Antigen-experienced Tumor-specific Cytolytic T Lymphocytes

1998 • 534 citations

New fluorescent dyes for lymphocyte migration studies

1990 • 498 citations

Dendritic Cell Vaccines for Cancer Immunotherapy

1999 • 497 citations

High Frequencies of Naive Melan-a/Mart-1–Specific Cd8+ T Cells in a Large Proportion of Human Histocompatibility Leukocyte Antigen (Hla)-A2 Individuals

1999 • 497 citations

Detection of Antigen-Specific T Cells with Multivalent Soluble Class II MHC Covalent Peptide Complexes

1998 • 465 citations

High Frequency of Skin-homing Melanocyte-specific Cytotoxic T Lymphocytes in Autoimmune Vitiligo

1998 • 446 citations

Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library

1999 • 442 citations

Monitoring CD8 T cell responses to NY-ESO-1: Correlation of humoral and cellular immune responses

2000 • 407 citations

MHC class II tetramers identify peptide-specific human CD4+ T cells proliferating in response to influenza A antigen

1999 • 379 citations

A recombinant vaccinia virus based ELISPOT assay detects high frequencies of Pol-specific CD8 T cells in HIV-1-positive individuals

1999 • 217 citations

Mature dendritic cells boost functionally superior CD8+ T-cell in humans without foreign helper epitopes

2000 • 201 citations

Individual Variations in the Murine T Cell Response to a Specific Peptide Reflect Variability in Naive Repertoires

1998 • 192 citations

Detection and quantification of blood-derived CD8+ T lymphocytes secreting tumor necrosis factor α in response to HLA-A2.1-binding melanoma and viral peptide antigens

1996 • 179 citations

Molecular detection and in vivo analysis of the specific T cell response to a protein antigen

1992 • 176 citations

Single-Cell PCR Analysis of TCR Repertoires Selected by Antigen In Vivo: A High Magnitude CD8 Response Is Comprised of Very Few Clones

1996 • 174 citations

Signaling defects in T lymphocytes of patients with malignancy

1999 • 166 citations

Efficient detection and immunomagnetic sorting of specific T cells using multimers of MHC class I and peptide with reduced CD8 binding

2000 • 155 citations

Anticancer drug targets: growth factors and growth factor signaling

2000 • 149 citations

A soluble divalent class I major histocompatibility complex molecule inhibits alloreactive T cells at nanomolar concentrations.

1993 • 144 citations

The use of computer-assisted video image analysis for the quantification of CD8+ T lymphocytes producing tumor necrosis factor α spots in response to peptide antigens

1997 • 142 citations

A flow cytometric method to estimate the precursor frequencies of cells proliferating in response to specific antigens

1999 • 133 citations

Precursor frequency analysis of human cytolytic T lymphocytes directed against autologous melanoma cells

1992 • 132 citations

Tumor-specific, cytotoxic T-lymphocyte response after idiotype vaccination for B-cell, non-Hodgkin's lymphoma

1996 • 129 citations

Immunotherapy of Metastatic Malignant Melanoma by a Vaccine Consisting of Autologous Interleukin 2-Transfected Cancer Cells: Outcome of a Phase I Study

1999 • 125 citations

How tumors escape immune destruction and what we can do about it

1999 • 122 citations

A Phase I Vaccine Trial with Peptides Reflecting ras Oncogene Mutations of Solid Tumors

1999 • 117 citations

Application of the ELISPOT assay to the characterization of CD8+ responses to Epstein-Barr virus antigens

2000 • 110 citations

Antigen-selected T-cell receptor diversity and self-nonself homology

1993 • 105 citations

ELISPOT Assay to Detect Cytokine‐Secreting Murine and Human Cells

2008 • 100 citations

Novel methods to monitor antigen-specific cytotoxic T-cell responses in cancer immunotherapy

1998 • 86 citations

The Composition of a Primary T Cell Response Is Largely Determined by the Timing of Recruitment of Individual T Cell Clones

1999 • 86 citations

Stimulation of CD8+ T cell responses to MAGE-3 and Melan A/MART-1 by immunization to a polyvalent melanoma vaccine

1997 • 65 citations

Reduced in vitro Production of Interferon-Gamma, Interleukin-4 and Interleukin-12 and Increased Production of Interleukin-6, Interleukin-10 and Tumour Necrosis Factor-Alpha in Systemic Lupus Erythematosus. Weak Correlations of Cytokine Production with Disease Activity

1999 • 47 citations

Differential Loss of T Cell Signaling Molecules in Metastatic Melanoma Patients’ T Lymphocyte Subsets Expressing Distinct TCR Variable Regions

1999 • 45 citations

Studying interactions involving the T-cell antigen receptor by surface plasmon resonance

1996 • 43 citations

<scp>ELISPOT</scp> Assay to Detect Cytokine‐Secreting Murine and Human Cells

1994 • 40 citations

Development of a dual color enzyme-linked immunospot assay for simultaneous detection of murine T helper type 1- and T helper type 2-cells

1998 • 38 citations

Active specific T-cell-based immunotherapy for cancer: nucleic acids, peptides, whole native proteins, recombinant viruses, with dendritic cell adjuvants or whole tumor cell-based vaccines. Principles and future prospects.

1998 • 38 citations

Individual cells simultaneously produce both IL-4 and IL-6 in vivo

1994 • 28 citations

Application of the ELISPOT assay to the characterization of CD8+ responses to Epstein-Barr virus antigens

2000 • 25 citations

Interpreting cancer vaccine clinical trials

1999 • 11 citations

Immune monitoring of cancer patients undergoing experimental immunotherapy.

2000 • 9 citations