Application of the ELISPOT assay to the characterization of CD8+ responses to Epstein-Barr virus antigens

Phenotypic Analysis of Antigen-Specific T Lymphocytes

1996 • 3,611 citations

CELLULAR RESPONSES TO INTERFERON-γ

1997 • 2,885 citations

Epstein-Barr Virus

1986 • 2,255 citations

Counting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection

1998 • 1,996 citations

Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function

1998 • 1,890 citations

Quantitation of HIV-1-Specific Cytotoxic T Lymphocytes and Plasma Load of Viral RNA

1998 • 1,426 citations

The Molecular Cell Biology of Interferon-gamma and its Receptor

1993 • 1,323 citations

Use of gene-modified virus-specific T lymphocytes to control Epstein-Barr-virus-related lymphoproliferation

1995 • 1,207 citations

Antigen Recognition by Class I-Restricted T Lymphocytes

1989 • 1,207 citations

Infusion of Cytotoxic T Cells for the Prevention and Treatment of Epstein-Barr Virus–Induced Lymphoma in Allogeneic Transplant Recipients

1998 • 1,103 citations

Biology and clinical relevance of human natural killer cells

1990 • 930 citations

Detection of Epstein–Barr Viral Genomes in Reed–Sternberg Cells of Hodgkin's Disease

1989 • 917 citations

Direct Visualization of Antigen-specific CD8+T Cells during the Primary Immune Response to Epstein-Barr Virus In Vivo

1998 • 902 citations

Expression of Epstein–Barr Virus Transformation–Associated Genes in Tissues of Patients with EBV Lymphoproliferative Disease

1989 • 803 citations

A Re-Evaluation of the Frequency of CD8+ T Cells Specific for EBV in Healthy Virus Carriers

1999 • 520 citations

The Pathogenesis of Burkitt's Lymphoma

1990 • 477 citations

Demonstration of monoclonal EBV genomes in Hodgkin's disease and Ki-1- positive anaplastic large cell lymphoma by combined Southern blot and in situ hybridization [see comments]

1989 • 422 citations

Role of interferon-gamma in immune cell regulation.

1995 • 374 citations

Quantification of antigen specific CD8+ T cells using an ELISPOT assay

1995 • 367 citations

Immediate Early and Early Lytic Cycle Proteins Are Frequent Targets of the Epstein-Barr Virus–induced Cytotoxic T Cell Response

1997 • 362 citations

Role of interferon-γ in immune cell regulation

1995 • 295 citations

Epstein-Barr Virus (EBV)-Specific Cytotoxic T Lymphocytes for the Treatment of Patients With EBV-Positive Relapsed Hodgkin's Disease

1998 • 295 citations

Analysis of Gag-specific Cytotoxic T Lymphocytes in Simian Immunodeficiency Virus–infected Rhesus Monkeys by Cell Staining with a Tetrameric Major Histocompatibility Complex Class I–Peptide Complex

1998 • 281 citations

Direct visualization of antigen-specific T cells: HTLV-1 Tax11–19- specific CD8⁺T cells are activated in peripheral blood and accumulate in cerebrospinal fluid from HAM/TSP patients

1998 • 237 citations

The development of cellular immunity to Epstein-Barr virus after allogeneic bone marrow transplantation

1996 • 212 citations

Conserved CTL epitopes within EBV latent membrane protein 2: a potential target for CTL-based tumor therapy.

1997 • 210 citations

Latent and Replicating Forms of Epstein-Barr Virus DNA in Lymphomas and Lymphoproliferative Diseases

1989 • 208 citations

HLA A2.1-restricted cytotoxic T cells recognizing a range of Epstein-Barr virus isolates through a defined epitope in latent membrane protein LMP2

1993 • 191 citations

Consistent transcription of the Epstein-Barr virus LMP2 gene in nasopharyngeal carcinoma

1992 • 183 citations

Detection and quantification of blood-derived CD8+ T lymphocytes secreting tumor necrosis factor α in response to HLA-A2.1-binding melanoma and viral peptide antigens

1996 • 179 citations

Reconstitution of EBV-Specific T Cell Immunity in Solid Organ Transplant Recipients

1998 • 155 citations

Analysis of Major Histocompatibility Complex Class I, TAP Expression, and LMP2 Epitope Sequence in Epstein-Barr Virus–Positive Hodgkin's Disease

1998 • 150 citations

Immunohistochemical Detection of the Epstein-Barr Virus–Encoded Latent Membrane Protein 2A in Hodgkin's Disease and Infectious Mononucleosis

1997 • 147 citations

Direct comparison of ELISPOT and ELISA-based assays for detection of individual cytokine-secreting cells.

1994 • 142 citations

Detection of intracellular expression and secretion of interferon‐γ at the single‐cell level after activation of human T cells with tetanus toxoid in vitro

1990 • 130 citations

Specific cytotoxic T lymphocytes recognize the immediate-early transactivator Zta of Epstein-Barr virus

1995 • 130 citations

Isolation of Epstein-Barr Virus (EBV)-Specific Cytotoxic T Lymphocytes That Lyse Reed-Sternberg Cells: Implications for Immune-Mediated Therapy of EBV+ Hodgkin's Disease

1997 • 125 citations

HLA-B27 and HLA-A2 subtypes: structure, evolution and function

1989 • 119 citations

Analysis of the T cell response to tumor and viral peptide antigens by an IFNγ-ELISPOT assay

1997 • 113 citations

Molecular characterization of antigen-processing function in nasopharyngeal carcinoma (NPC): evidence for efficient presentation of Epstein-Barr virus cytotoxic T-cell epitopes by NPC cells.

1998 • 110 citations

BCL-2 but not its Epstein-Barr virus-encoded homologue, BHRF1, is commonly expressed in posttransplantation lymphoproliferative disorders [see comments]

1996 • 97 citations

TREATMENT OF POSTTRANSPLANT LYMPHOPROLIFERATIVE DISEASE IN THE CENTRAL NERVOUS SYSTEM OF A LUNG TRANSPLANT RECIPIENT USING ALLOGENEIC LEUKOCYTES1

1997 • 73 citations

Identification of Epstein-Barr virus lytic activity in post-transplantation lymphoproliferative disease.

1996 • 68 citations

Specific expression of surface interferon‐γ on interferon‐γ producing T cells from mouse and man

1996 • 64 citations

Immediate-Early Transactivator Rta of Epstein-Barr Virus (EBV) Shows Multiple Epitopes Recognized by EBV-Specific Cytotoxic T Lymphocytes

1998 • 57 citations

Treatment of relapsed Hodgkin’s disease using EBV-specific cytotoxic T cells

1998 • 51 citations

Quantitation of human influenza virus-specific cytotoxic T lymphocytes: correlation of cytotoxicity and increased numbers of IFN-γ producing CD8⁺ T cells

1994 • 50 citations

High frequency of Epstein–Barr virus (EBV) lymphoblastoid cell line-reactive lymphocytes in cord blood: evaluation of cytolytic activity and IL-2 production

1997 • 36 citations

Feasibility of Cellular Adoptive Immunotherapy for Epstein-Barr Virus-Associated Lymphomas Using Haploidentical Donors

1998 • 34 citations

Cryopreservation of whole blood and isolated lymphocytes for B-cell immortalization

1993 • 28 citations