Visceral Leishmaniasis in Mice Devoid of Tumor Necrosis Factor and Response to Treatment

Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1).

1986 • 2,490 citations

The Pathophysiology of Tumor Necrosis Factors

1992 • 1,880 citations

Tumor necrosis factor-α is required in the protective immune response against mycobacterium tuberculosis in mice

1995 • 1,643 citations

Mice lacking the tumour necrosis factor receptor 1 are resistant to IMF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes

1993 • 1,267 citations

Characterization of tumor necrosis factor-deficient mice

1997 • 792 citations

Structural Deficiencies in Granuloma Formation in TNF Gene-Targeted Mice Underlie the Heightened Susceptibility to Aerosol Mycobacterium tuberculosis Infection, Which Is Not Compensated for by Lymphotoxin

1999 • 612 citations

Tumor necrosis factor-alpha synergizes with IFN-gamma in mediating killing of Leishmania major through the induction of nitric oxide.

1990 • 531 citations

Macrophage Microbicidal Mechanisms In Vivo: Reactive Nitrogen versus Oxygen Intermediates in the Killing of Intracellular Visceral Leishmania donovani

1999 • 417 citations

Tumor necrosis factor: an updated review of its biology.

1993 • 284 citations

Trial of oral miltefosine for visceral leishmaniasis

1998 • 242 citations

Tumor necrosis factor in the pathogenesis of infectious diseases

1993 • 239 citations

IL-10 production is enhanced in human T cells by IL-12 and IL-6 and in monocytes by tumor necrosis factor-alpha.

1996 • 163 citations

Intracellular Antimicrobial Activity in the Absence of Interferon-γ: Effect of Interleukin-12 in Experimental Visceral Leishmaniasis in Interferon-γ Gene-disrupted Mice

1997 • 162 citations

Mice lacking the TNF receptor p55 fail to resolve lesions caused by infection with Leishmania major, but control parasite replication.

1996 • 151 citations

Decreased Resistance of TNF Receptor p55- and p75-Deficient Mice to Chronic Toxoplasmosis Despite Normal Activation of Inducible Nitric Oxide Synthase In Vivo

1998 • 145 citations

Role and effect of TNF-alpha in experimental visceral leishmaniasis.

1994 • 141 citations

Role of inorganic nitrogen oxides and tumor necrosis factor alpha in killing Leishmania donovani amastigotes in gamma interferon-lipopolysaccharide-activated macrophages from Lshs and Lshr congenic mouse strains

1991 • 139 citations

Inhibition of interferon γ induced interleukin 12 production: A potential mechanism for the anti-inflammatory activities of tumor necrosis factor

1998 • 135 citations

Immunomodulatory and immunotherapeutic properties of recombinant gamma-interferon and recombinant tumor necrosis factor in mice.

1987 • 132 citations

Crucial role of TNF receptor type 1 (p55), but not of TNF receptor type 2 (p75), in murine toxoplasmosis.

1998 • 130 citations

Fatal Granuloma Necrosis without Exacerbated Mycobacterial Growth in Tumor Necrosis Factor Receptor p55 Gene-Deficient Mice Intravenously Infected withMycobacterium avium

1999 • 128 citations

Requirement for T cells and effect of lymphokines in successful chemotherapy for an intracellular infection. Experimental visceral leishmaniasis.

1989 • 125 citations

Crucial Role of TNF Receptor Type 1 (p55), But Not of TNF Receptor Type 2 (p75), in Murine Toxoplasmosis

1998 • 119 citations

Roles of Endogenous Gamma Interferon and Macrophage Microbicidal Mechanisms in Host Response to Chemotherapy in Experimental Visceral Leishmaniasis

2000 • 116 citations

Modulation of in vitro monocyte cytokine responses to Leishmania donovani. Interferon-gamma prevents parasite-induced inhibition of interleukin 1 production and primes monocytes to respond to Leishmania by producing both tumor necrosis factor-alpha and interleukin 1.

1990 • 102 citations

Costimulation by purified intercellular adhesion molecule 1 and lymphocyte function-associated antigen 3 induces distinct proliferation, cytokine and cell surface antigen profiles in human "naive" and "memory" CD4+ T cells.

1994 • 100 citations

Endogenous Interleukin‐12 Regulates Acquired Resistance in Experimental Visceral Leishmaniasis

1997 • 99 citations

Control ofLeishmania majorInfection in Mice Lacking TNF Receptors

1998 • 88 citations

TNF Receptor p55 Is Required for Elimination of Inflammatory Cells Following Control of Intracellular Pathogens

1999 • 69 citations

Visceral Leishmanicidal Activity of Hexadecylphosphocholine (Miltefosine) in Mice Deficient in T Cells and Activated Macrophage Microbicidal Mechanisms

2000 • 59 citations

Augmentation of murine tumor necrosis factor production by amphotericin B in vitro and in vivo

1993 • 58 citations

Cytokine interactions in experimental cutaneous leishmaniasis. II. Endogenous tumor necrosis factor‐α production by macrophages is induced by the synergistic action of interferon (IFN)‐γ and interleukin (IL) 4 and accounts for the antiparasitic effect mediated by IFN‐γ and IL 4

1991 • 57 citations

Treatment of experimental visceral leishmaniasis in a T-cell-deficient host: response to amphotericin B and pentamidine

1993 • 47 citations

Influence of hexadecylphosphocholine on the release of tumor necrosis factor and nitroxide from peritoneal macrophages in vitro

1995 • 46 citations

Enhanced Sensitivity of Tumor Necrosis Factor/Lymphotoxin‐α–Deficient Mice toCryptococcus neoformansInfection despite Increased Levels of Nitrite/Nitrate, Interferon‐γ, and Interleukin‐12

1999 • 37 citations

Activated T Cells Induce Macrophages To Produce NO and ControlLeishmania majorin the Absence of Tumor Necrosis Factor Receptor p55

2000 • 33 citations

Cytokine interactions in experimental cutaneous leishmaniasis.

1991 • 28 citations

Models of Relapse of Experimental Visceral Leishmaniasis

1996 • 28 citations

Strategies for immune intervention in visceral leishmaniasis

1995 • 18 citations