Ras‐Dependent and Ras‐Independent Activation Pathways for the Stress‐Activated‐Protein‐Kinase Cascade

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1994 • 3,285 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells

1994 • 2,659 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine

1995 • 2,238 citations

The mitogen-activated protein kinase signal transduction pathway

1993 • 2,174 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

1993 • 1,902 citations

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

1994 • 1,684 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms

1995 • 1,562 citations

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1995 • 1,499 citations

Transformation of Mammalian Cells by Constitutively Active MAP Kinase Kinase

1994 • 1,370 citations

Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-β Signal Transduction

1995 • 1,318 citations

Raf-1 activates MAP kinase-kinase

1992 • 1,308 citations

Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK

1994 • 1,092 citations

The MAP kinase cascade is essential for diverse signal transduction pathways

1993 • 1,091 citations

Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase

1990 • 1,087 citations

A Divergence in the MAP Kinase Regulatory Network Defined by MEK Kinase and Raf

1993 • 1,086 citations

Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase).

1991 • 1,041 citations

Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation.

1993 • 992 citations

Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun

1994 • 978 citations

Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of hsp27

1994 • 866 citations

Activation of the MAP kinase pathway by the protein kinase raf

1992 • 816 citations

Identification of a Dual Specificity Kinase That Activates the Jun Kinases and p38-Mpk2

1995 • 775 citations

Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1

1994 • 706 citations

Activation of Mitogen-Activated Protein Kinase Kinase by v-Raf in NIH 3T3 Cells and in Vitro

1992 • 691 citations

Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts

1993 • 668 citations

Raf meets Ras: completing the framework of a signal transduction pathway

1994 • 591 citations

The ins and outs of Raf kinases

1994 • 537 citations

Induction of c-fos expression through JNK-mediated TCF/Elk-1 phosphorylation.

1995 • 535 citations

Extracellular signal-regulated kinases: ERKs in progress.

1991 • 519 citations

c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases.

1994 • 463 citations

Recent progress in characterization of protein kinase cascades for phosphorylation of ribosomal protein S6

1991 • 442 citations

Mitogen-activated protein kinases: versatile transducers for cell signaling

1992 • 439 citations

Microtubule‐associated‐protein (MAP) kinase activated by nerve growth factor and epidermal growth factor in PC12 cells

1990 • 386 citations

Serum-induced translocation of mitogen-activated protein kinase to the cell surface ruffling membrane and the nucleus

1993 • 328 citations

Ras-dependent growth factor regulation of MEK kinase in PC12 cells

1994 • 322 citations

Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase.

1996 • 308 citations

Xenopus M phase MAP kinase: isolation of its cDNA and activation by MPF.

1991 • 274 citations

Xenopus MAP kinase activator: identification and function as a key intermediate in the phosphorylation cascade.

1992 • 264 citations

pp54 microtubule-associated protein 2 kinase. A novel serine/threonine protein kinase regulated by phosphorylation and stimulated by poly-L-lysine.

1990 • 256 citations

Phorbol ester, calcium ionophore, or serum added to quiescent rat embryo fibroblast cells all result in the elevated phosphorylation of two 28,000-dalton mammalian stress proteins.

1985 • 233 citations

Xenopus MAP kinase activator is a serine/threonine/tyrosine kinase activated by threonine phosphorylation.

1992 • 232 citations

Induction of four proteins in chick embryo cells by sodium arsenite.

1980 • 219 citations

Requirement for the MAP kinase kinase/MAP kinase cascade in Xenopus oocyte maturation.

1994 • 207 citations

Role of MAP kinase in mesoderm induction and axial patterning during Xenopus development

1995 • 155 citations

Activation of Protein Kinase Cascades by Osmotic Shock

1995 • 154 citations

Activation of Fes Tyrosine Kinase by gp130, an Interleukin-6 Family Cytokine Signal Transducer, and Their Association

1995 • 147 citations

Induction of neurite outgrowth by MAP kinase in PC12 cells.

1995 • 146 citations

Involvement of the MAP kinase cascade in Xenopus mesoderm induction.

1995 • 136 citations

Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain.

1996 • 134 citations

Evidence for Multiple Activators for Stress-activated Protein Kinases/c-Jun Amino-terminal Kinases.

1995 • 114 citations

pp54 microtubule-associated protein-2 kinase requires both tyrosine and serine/threonine phosphorylation for activity

1991 • 108 citations

MAP kinase regulation — the oncogene connection

1992 • 76 citations

Novel members of the mitogen-activated protein kinase activator family in Xenopus laevis.

1993 • 67 citations

Characterization of recombinant Xenopus MAP kinase kinases mutated at potential phosphorylation sites.

1994 • 57 citations

Analysis of the Ras p21/mitogen-activated protein kinase signaling in vitro and in Xenopus oocytes

1994 • 23 citations