Regulation of fibronectin matrix deposition and cell proliferation by the PINCH‐ILK‐CH‐ILKBP complex

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Integrins and Signal Transduction Pathways: the Road Taken

1995 • 3,002 citations

FOCAL ADHESIONS, CONTRACTILITY, AND SIGNALING

1996 • 1,900 citations

Integrins: Emerging Paradigms of Signal Transduction

1995 • 1,591 citations

Regulation of cell adhesion and anchorage-dependent growth by a new β1-integrin-linked protein kinase

1996 • 1,106 citations

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

1998 • 1,097 citations

Function and interactions of integrins

2001 • 1,018 citations

Molecular interactions in cell adhesion complexes

1997 • 583 citations

Dynamics and segregation of cell–matrix adhesions in cultured fibroblasts

2000 • 574 citations

Integrins and cell proliferation

2001 • 509 citations

Integrin Dynamics and Matrix Assembly

2000 • 459 citations

Molecular diversity of cell-matrix adhesions

1999 • 444 citations

Integrin-linked kinase (ILK) and its interactors

2001 • 441 citations

Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells

2000 • 430 citations

Physical State of the Extracellular Matrix Regulates the Structure and Molecular Composition of Cell-Matrix Adhesions

2000 • 402 citations

Integrin cytoplasmic interactions and bidirectional transmembrane signalling

1996 • 396 citations

Integrin activation and cytoskeletal interaction are essential for the assembly of a fibronectin matrix

1995 • 349 citations

Active ERK/MAP kinase is targeted to newly forming cell-matrix adhesions by integrin engagement and v-Src

2000 • 336 citations

Genes critical for muscle development and function in Caenorhabditis elegans identified through lethal mutations

1994 • 332 citations

Fibronectin fibrillogenesis: a paradigm for extracellular matrix assembly

1999 • 303 citations

The LIM-Only Protein PINCH Directly Interacts with Integrin-Linked Kinase and Is Recruited to Integrin-Rich Sites in Spreading Cells

1999 • 300 citations

Integrin-linked Protein Kinase Regulates Fibronectin Matrix Assembly, E-cadherin Expression, and Tumorigenicity

1998 • 279 citations

Drosophila Integrin-Linked Kinase Is Required at Sites of Integrin Adhesion to Link the Cytoskeleton to the Plasma Membrane

2001 • 278 citations

Overexpression of the Integrin-linked Kinase Promotes Anchorage-independent Cell Cycle Progression

1997 • 259 citations

The Integrin-linked Kinase Regulates the Cyclin D1 Gene through Glycogen Synthase Kinase 3β and cAMP-responsive Element-binding Protein-dependent Pathways

2000 • 243 citations

Integrin-linked kinase (ILK): a regulator of integrin and growth-factor signalling

1999 • 237 citations

Fibronectin Matrix Regulates Activation of RHO and CDC42 GTPases and Cell Cycle Progression

1998 • 234 citations

Single subunit chimeric integrins as mimics and inhibitors of endogenous integrin functions in receptor localization, cell spreading and migration, and matrix assembly.

1994 • 234 citations

A New Focal Adhesion Protein That Interacts with Integrin-Linked Kinase and Regulates Cell Adhesion and Spreading

2001 • 228 citations

Characterization of beta pat-3 heterodimers, a family of essential integrin receptors in C. elegans.

1995 • 209 citations

Integrin-linked Kinase (ILK) Binding to Paxillin LD1 Motif Regulates ILK Localization to Focal Adhesions

2001 • 208 citations

A Conserved LIM Protein That Affects Muscular Adherens Junction Integrity and Mechanosensory Function in Caenorhabditis elegans

1999 • 208 citations

A Novel Integrin-Linked Kinase–Binding Protein, Affixin, Is Involved in the Early Stage of Cell–Substrate Interaction

2001 • 207 citations

TGF-β1 stimulates cultured human fibroblasts to proliferate and produce tissue-like fibroplasia: A fibronectin matrix-dependent event

1997 • 201 citations

Actopaxin, a New Focal Adhesion Protein That Binds Paxillin Ld Motifs and Actin and Regulates Cell Adhesion

2000 • 196 citations

Integrin-linked kinase is localized to cell-matrix focal adhesions but not cell-cell adhesion sites and the focal adhesion localization of integrin-linked kinase is regulated by the PINCH-binding ANK repeats

1999 • 188 citations

Cell cycle regulation in diabetic nephropathy

2000 • 166 citations

Fibronectin matrix assembly enhances adhesion-dependent cell growth

1998 • 165 citations

The alpha 5 beta 1 integrin fibronectin receptor, but not the alpha 5 cytoplasmic domain, functions in an early and essential step in fibronectin matrix assembly.

1993 • 160 citations

Assembly of extracellular matrix

1992 • 159 citations

Parvin, a 42 kDa focal adhesion protein, related to the α-actinin superfamily

2001 • 148 citations

Control of Cell Cycle Progression by Fibronectin Matrix Architecture

1998 • 141 citations

Dysfunctions of cell biological mechanisms of visceral epithelial cell (podocytes) in glomerular diseases

1994 • 124 citations

A Critical Role of the PINCH-Integrin-linked Kinase Interaction in the Regulation of Cell Shape Change and Migration

2002 • 117 citations

Integrin-linked kinase and PINCH: partners in regulation of cell-extracellular matrix interaction and signal transduction

1999 • 115 citations

Cytokines and mesangial cells.

1993 • 115 citations

Integrin linked kinase as a candidate downstream effector in proteinuria

2001 • 107 citations

Identification of a New Biological Function for the Integrin α_vβ₃: Initiation of Fibronectin Matrix Assembly

1996 • 106 citations

Role of Platelet-Derived Growth Factor in Renal Injury

1995 • 103 citations

A novel role for α3β1 integrins in extracellular matrix assembly

1995 • 101 citations

Localization of cell surface sites involved in fibronectin fibrillogenesis.

1987 • 95 citations

Localization of fibronectin matrix assembly sites on fibroblasts and endothelial cells

1997 • 94 citations

Inhibition of Vascular Smooth Muscle Cell Growth by Inhibition of Fibronectin Matrix Assembly

1998 • 93 citations

The Distribution and Regulation of Integrin-Linked Kinase in Normal and Diabetic Kidneys

2001 • 84 citations

The glomerular mesangium in diabetes mellitus

1993 • 78 citations

The Roles of Integrin-Linked Kinase in the Regulation of Myogenic Differentiation

2000 • 78 citations

Progression of Diabetic Nephropathy

1999 • 71 citations

Phosphorylation of the β1 Integrin Cytoplasmic Domain: Toward an Understanding of Function and Mechanism

2000 • 55 citations

Diabetic nephropathy. Mechanisms of mesangial matrix expansion.

1995 • 51 citations

Integrin signaling

1996 • 50 citations

Roles of integrins in fibronectin matrix assembly.

1997 • 43 citations

ILK interactions

2001 • 38 citations

Requirement for Tyrosine Kinase-ERK1/2 Signaling in α1β1 Integrin-Mediated Collagen Matrix Remodeling by Rat Mesangial Cells

2001 • 35 citations

Overexpression of α1β1 integrin directly affects rat mesangial cell behavior

2000 • 30 citations

Structure-function relationships in diabetic nephropathy: lessons and limitations.

1997 • 13 citations

The alpha 5 beta 1 integrin fibronectin receptor, but not the alpha 5 cytoplasmic domain, functions in an early and essential step in fibronectin matrix assembly.

1993 • 2 citations