Integrin-linked kinase is localized to cell-matrix focal adhesions but not cell-cell adhesion sites and the focal adhesion localization of integrin-linked kinase is regulated by the PINCH-binding ANK repeats

FOCAL ADHESIONS, CONTRACTILITY, AND SIGNALING

1996 • 1,900 citations

Integrins: Emerging Paradigms of Signal Transduction

1995 • 1,591 citations

Regulation of cell adhesion and anchorage-dependent growth by a new β1-integrin-linked protein kinase

1996 • 1,106 citations

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

1998 • 1,097 citations

Paxillin: a new vinculin-binding protein present in focal adhesions.

1990 • 687 citations

The Molecular Architecture of Focal Adhesions

1995 • 479 citations

Cell adhesion and the integrin-linked kinase regulate the LEF-1 and β-catenin signaling pathways

1998 • 421 citations

Src family protein tyrosine kinases: cooperating with growth factor and adhesion signaling pathways

1997 • 401 citations

Integrin cytoplasmic interactions and bidirectional transmembrane signalling

1996 • 396 citations

Protein kinase C involvement in focal adhesion formation

1992 • 361 citations

Identification of LIM3 as the principal determinant of paxillin focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal adhesion kinase binding.

1996 • 347 citations

Zyxin and cCRP: two interactive LIM domain proteins associated with the cytoskeleton.

1992 • 344 citations

Association of type 3 protein kinase C with focal contacts in rat embryo fibroblasts.

1989 • 310 citations

The LIM-Only Protein PINCH Directly Interacts with Integrin-Linked Kinase and Is Recruited to Integrin-Rich Sites in Spreading Cells

1999 • 300 citations

Regulation of fibronectin receptor distribution [published erratum appears in J Cell Biol 1992 Jul;118(2):491]

1992 • 295 citations

Identification of amino acid sequences in the integrin beta 1 cytoplasmic domain implicated in cytoskeletal association

1992 • 285 citations

Integrin-linked Protein Kinase Regulates Fibronectin Matrix Assembly, E-cadherin Expression, and Tumorigenicity

1998 • 279 citations

Syndecan-4 Proteoglycan Regulates the Distribution and Activity of Protein Kinase C

1997 • 278 citations

Direct association of pp125FAK with paxillin, the focal adhesion-targeting mechanism of pp125FAK.

1995 • 261 citations

Focal adhesion kinase: at the crossroads of signal transduction

1997 • 260 citations

Overexpression of the Integrin-linked Kinase Promotes Anchorage-independent Cell Cycle Progression

1997 • 259 citations

Products of the unc-52 gene in Caenorhabditis elegans are homologous to the core protein of the mammalian basement membrane heparan sulfate proteoglycan.

1993 • 251 citations

Single subunit chimeric integrins as mimics and inhibitors of endogenous integrin functions in receptor localization, cell spreading and migration, and matrix assembly.

1994 • 234 citations

Zyxin: Zinc fingers at sites of cell adhesion

1997 • 213 citations

Multimerization of the Cytoplasmic Domain of Syndecan-4 Is Required for Its Ability to Activate Protein Kinase C

1997 • 209 citations

Characterization of beta pat-3 heterodimers, a family of essential integrin receptors in C. elegans.

1995 • 209 citations

A Conserved LIM Protein That Affects Muscular Adherens Junction Integrity and Mechanosensory Function in Caenorhabditis elegans

1999 • 208 citations

Nck-2, a Novel Src Homology2/3-containing Adaptor Protein That Interacts with the LIM-only Protein PINCH and Components of Growth Factor Receptor Kinase-signaling Pathways

1998 • 188 citations

Vinculin is essential for muscle function in the nematode.

1991 • 173 citations

The RhoA-dependent assembly of focal adhesions in Swiss 3T3 cells is associated with increased tyrosine phosphorylation and the recruitment of both pp125FAK and protein kinase C-δ to focal adhesions

1994 • 168 citations

A novel integrin beta subunit is associated with the vitronectin receptor alpha subunit (alpha v) in a human osteosarcoma cell line and is a substrate for protein kinase C.

1989 • 167 citations

The fibronectin receptor is organized by extracellular matrix fibronectin: implications for oncogenic transformation and for cell recognition of fibronectin matrices.

1989 • 150 citations

Serine and Threonine Phosphorylation of the Paxillin LIM Domains Regulates Paxillin Focal Adhesion Localization and Cell Adhesion to Fibronectin

1998 • 136 citations

Dissociation of FAK/p130CAS/c-Src Complex during Mitosis: Role of Mitosis-specific Serine Phosphorylation of FAK

1999 • 121 citations

Adhesion of fibroblasts to fibronectin stimulates both serine and tyrosine phosphorylation of paxillin

1997 • 112 citations

Integrin αvβ5-dependent Serine Phosphorylation of Paxillin in Cultured Human Macrophages Adherent to Vitronectin

1996 • 110 citations

Molecular dissection of a LIM domain.

1997 • 95 citations

Phosphorylation of dense-plaque proteins talin and paxillin during tracheal smooth muscle contraction

1995 • 82 citations

ILK (?1-integrin-linked protein kinase): a novel immunohistochemical marker for Ewing's sarcoma and primitive neuroectodermal tumour

1998 • 62 citations

The role of phosphorylation in activation of the alpha 6A beta 1 laminin receptor.

1993 • 50 citations

The adhesion plaque protein, talin, is phosphorylated in vivo in chicken embryo fibroblasts exposed to a tumor-promoting phorbol ester.

1990 • 41 citations

Identification of integrin-stimulated sites of serine phosphorylation in FRNK, the separately expressed C-terminal domain of focal adhesion kinase: a potential role for protein kinase A

1997 • 32 citations

Expression of the Integrin-Linked Kinase (ILK) in Mouse Skin

1998 • 29 citations

Identification and characterization of a mouse protein kinase that is highly homologous to human integrin-linked kinase1The sequence data have been deposited with the GenBank (accession number U94479).1

1997 • 27 citations

The Role of Phosphorylation in Modulating β1Integrin Localization

1996 • 25 citations

Evidence That β1 Integrins in Keratinocyte Cell–Cell Junctions Are Not in the Ligand-Occupied Conformation

1997 • 23 citations

Calcium-Induced Intercellular Adhesion of Keratinocytes Does not Involve Accumulation of β₁Integrins at Cell-Cell Contacts and Does not Involve Changes in the Levels or Phosphorylation of Catenins

1998 • 17 citations

Lack of intrinsic polarity in the ligandbinding ability of keratinocyte β₁ integrins

1998 • 12 citations