A Small Interfering RNA Targeting Vascular Endothelial Growth Factor as Cancer Therapeutics

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

1998 • 14,674 citations

Tumor Angiogenesis: Therapeutic Implications

1971 • 9,898 citations

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

2001 • 9,275 citations

Angiogenesis in cancer, vascular, rheumatoid and other disease

1995 • 7,717 citations

Vascular Endothelial Growth Factor Is a Secreted Angiogenic Mitogen

1989 • 4,988 citations

Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

1993 • 3,605 citations

VEGF-Trap: A VEGF blocker with potent antitumor effects

2002 • 1,641 citations

Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors

2003 • 1,236 citations

Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors

2003 • 1,172 citations

Analysis of gene function in somatic mammalian cells using small interfering RNAs

2002 • 1,108 citations

Angiogenesis and Tumor Metastasis

1998 • 1,013 citations

Placental Growth Factor, a Member of the VEGF Family, Contributes to the Development of Choroidal Neovascularization

2003 • 315 citations

Selective inhibition of vascular endothelial growth factor (VEGF) receptor 2 (KDR/Flk-1) activity by a monoclonal anti-VEGF antibody blocks tumor growth in mice.

2000 • 309 citations

Antisense RNA to the type I insulin-like growth factor receptor suppresses tumor growth and prevents invasion by rat prostate cancer cells in vivo.

1996 • 239 citations

New delivery system for plasmid DNA in vivo using atelocollagen as a carrier material: the Minipellet

1999 • 232 citations

Expression of VEGF‐C and VEGF‐D at the invasive edge correlates with lymph node metastasis and prognosis of patients with colorectal carcinoma

2004 • 151 citations

Antisense oligodeoxynucleotide targeted to Midkine, a heparin-binding growth factor, suppresses tumorigenicity of mouse rectal carcinoma cells.

2001 • 141 citations

Atelocollagen-Based Gene Transfer in Cells Allows High-Throughput Screening of Gene Functions

2001 • 80 citations

5′-,3′-Inverted Thymidine-modified Antisense Oligodeoxynucleotide Targeting Midkine

2002 • 50 citations