Antisense RNA to the type I insulin-like growth factor receptor suppresses tumor growth and prevents invasion by rat prostate cancer cells in vivo.

Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.

1986 • 1,866 citations

Biology and biochemistry of proteinases in tumor invasion

1993 • 1,264 citations

The insulin-like growth factor I receptor: a key to tumor growth?

1995 • 549 citations

Acceleration of human prostate cancer growth in vivo by factors produced by prostate and bone fibroblasts.

1991 • 449 citations

Sequence of cDNA encoding human insulin-like growth factor I precursor

1983 • 401 citations

The insulin-like growth factor I receptor protects tumor cells from apoptosis in vivo.

1995 • 385 citations

Blockade of the type I somatomedin receptor inhibits growth of human breast cancer cells in athymic mice.

1989 • 334 citations

Treatment and Prevention of Rat Glioblastoma by Immunogenic C6 Cells Expressing Antisense Insulin-Like Growth Factor I RNA

1993 • 328 citations

Rat glioblastoma cells expressing an antisense RNA to the insulin-like growth factor-1 (IGF-1) receptor are nontumorigenic and induce regression of wild-type tumors.

1994 • 310 citations

Inhibition of growth of prostatic cancer cell lines by peptide analogues of insulin-like growth factor 1.

1993 • 240 citations

Osteolytic bone metastasis in breast cancer

1994 • 238 citations

Growth inhibition of human melanoma cells in nude mice by antisense strategies to the type 1 insulin-like growth factor receptor.

1994 • 234 citations

Oncogenes and the strategy of growth factors

1994 • 232 citations

Urokinase overproduction results in increased skeletal metastasis by prostate cancer cells in vivo.

1994 • 225 citations

Insulin‐like growth factor I: Action and receptor characterization in human prostate cancer cell lines

1993 • 215 citations

Dominant negative inhibition of tumorigenesis in vivo by human insulin-like growth factor I receptor mutant.

1994 • 195 citations

In vivo treatment with antibody against IGF-1 receptor suppresses growth of human rhabdomyosarcoma and down-regulates p34cdc2.

1994 • 186 citations

Loss of tumorigenicity of rat glioblastoma directed by episome-based antisense cDNA transcription of insulin-like growth factor I.

1992 • 180 citations

Molecular cloning of complementary DNA to mouse tissue plasminogen activator mRNA and its expression during F9 teratocarcinoma cell differentiation.

1988 • 156 citations

Loss of the metastatic phenotype in murine carcinoma cells expressing an antisense RNA to the insulin-like growth factor receptor.

1995 • 141 citations

Spontaneous Prostate Adenocarcinomas in Aged Germfree Wistar Rats2

1973 • 126 citations

Insulin-like growth factors I and II are present in the skeletal tissues of ten vertebrates

1990 • 126 citations

Osteoblastic metastasis in advanced prostate cancer.

1993 • 108 citations

Insulin-like growth factor-1 and its receptor mediate the autocrine proliferation of human ovarian carcinoma cell lines.

1993 • 98 citations

Sequence of a Placental cDNA Encoding the Mouse Insulin-Like Growth Factor II Precursor

1986 • 93 citations

Molecular and cellular changes associated with the acquisition of metastatic ability by prostatic cancer cells

1994 • 90 citations

Antibody to type I insulinlike growth factor receptor inhibits growth of Wilms' tumor in culture and in athymic mice.

1989 • 88 citations

Mitogenic effects of insulin and insulin‐like growth factors on PA‐III rat prostate adenocarcinoma cells: Characterization of the receptors involved

1991 • 80 citations

Urokinase-type plasminogen activator: a paracrine factor regulating the bioavailability of IGFs in PA-III cell-induced osteoblastic metastases.

1993 • 78 citations

Quantitative comparison between the transplantability of human and murine tumors into the subcutaneous tissue of NCr/Sed-nu/nu nude and severe combined immunodeficient mice.

1993 • 61 citations

Effects of Dichloromethylene Diphosphonate on the Osteolytic and Osteoplastic Effects of Rat Prostate Adenocarcinoma Cells2

1985 • 49 citations

Gene therapy of murine teratocarcinoma: separate functions for insulin-like growth factors I and II in immunogenicity and differentiation.

1994 • 41 citations

Differential regulation of astrocyte plasminogen activators by insulin-like growth factor-I and epidermal growth factor.

1994 • 35 citations

Prostate tumor progression and metastasis

1987 • 26 citations

Characterization of pathological dystrophin transcripts from the lymphocytes of a muscular dystrophy carrier.

1990 • 24 citations

Systemic therapy of prostate cancer. new concepts from prostate cancer tumor biology

1993 • 18 citations

Prostatic localization of spontaneous early invasive carcinoma in Lobund-Wistar rats.

1994 • 14 citations

Plasminogen activators in nude mice xenotransplanted with human tumorigenic cells.

1995 • 5 citations

[Expression of human urokinase in inoculated rodent cells. Loss of introns during gene transfer using a retroviral vector].

1992 • 2 citations

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