Neonatal Exendin-4 Prevents the Development of Diabetes in the Intrauterine Growth Retarded Rat

Fetal and infant growth and impaired glucose tolerance at age 64.

1991 • 2,734 citations

INFANT MORTALITY, CHILDHOOD NUTRITION, AND ISCHAEMIC HEART DISEASE IN ENGLAND AND WALES

1986 • 2,727 citations

Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth

1993 • 2,484 citations

Obesity in Young Men after Famine Exposure in Utero and Early Infancy

1976 • 1,618 citations

Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats.

1999 • 1,207 citations

Control of endodermal endocrine development by Hes-1

2000 • 1,135 citations

The Glucagon-Like Peptides

1999 • 1,018 citations

Intrauterine Growth Retardation Leads to the Development of Type 2 Diabetes in the Rat

2001 • 639 citations

Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas.

2000 • 590 citations

Glucagon-like Peptide-1 Receptor Signaling Modulates β Cell Apoptosis

2002 • 583 citations

Birthweight and the Risk for Type 2 Diabetes Mellitus in Adult Women

1999 • 549 citations

Birthweight and adult health outcomes in a biethnic population in the USA

1994 • 526 citations

Glucagon-Like Peptide-1 Promotes Islet Cell Growth and Inhibits Apoptosis in Zucker Diabetic Rats

2002 • 507 citations

Compensatory Growth of Pancreatic β-Cells in Adult Rats After Short-Term Glucose Infusion

1989 • 447 citations

The Genetic Basis of Type 2 Diabetes Mellitus: Impaired Insulin Secretion versus Impaired Insulin Sensitivity

1998 • 421 citations

Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells

1999 • 405 citations

Apoptosis Participates in the Remodeling of the Endocrine Pancreas in the Neonatal Rat*

1997 • 399 citations

Reduction in Pancreatic Transcription Factor PDX-1 Impairs Glucose-stimulated Insulin Secretion

2002 • 379 citations

Insulin Resistance Early in Adulthood in Subjects Born with Intrauterine Growth Retardation¹

2000 • 357 citations

The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration.

1999 • 339 citations

Glucagon-like peptide-1 treatment delays the onset of diabetes in 8 week-old db/db mice

2002 • 318 citations

Persistent Improvement of Type 2 Diabetes in the Goto-Kakizaki Rat Model by Expansion of the β-Cell Mass During the Prediabetic Period With Glucagon-Like Peptide-1 or Exendin-4

2002 • 288 citations

The long-acting GLP-1 derivative NN2211 ameliorates glycemia and increases β-cell mass in diabetic mice

2002 • 280 citations

Insulin Resistance Early in Adulthood in Subjects Born with Intrauterine Growth Retardation

2000 • 253 citations

Transcribing pancreas.

1998 • 252 citations

Perspective: Postnatal Pancreatic β Cell Growth

2000 • 248 citations

Glucose Stimulates Translocation of the Homeodomain Transcription Factor PDX1 from the Cytoplasm to the Nucleus in Pancreatic β-Cells

1999 • 219 citations

THE ENDOCRINE PANCREAS IN SMALL‐FOR‐DATES INFANTS

1977 • 180 citations

Pdx1 restores β cell function in Irs2 knockout mice

2002 • 179 citations

The p38/Reactivating Kinase Mitogen-activated Protein Kinase Cascade Mediates the Activation of the Transcription Factor Insulin Upstream Factor 1 and Insulin Gene Transcription by High Glucose in Pancreatic β-Cells

1997 • 176 citations

Glucose tolerance and resistance to insulin-stimulated glucose uptake in men aged 70 years in relation to size at birth

1998 • 172 citations

Altered gas exchange, limited glucose and branched chain amino acids, and hypoinsulinism retard fetal growth in the rat

1986 • 172 citations

Pancreatic β Cell-specific Transcription of thepdx-1 Gene

2000 • 161 citations

Growth dynamics of pancreatic islet cell populations during fetal and neonatal development of the rat

1994 • 156 citations

Initiation of Increased Pancreatic Islet Growth in Young Normoglycemic Mice (Umeå +/?)*

1999 • 153 citations

Pdx1 restores β cell function in Irs2 knockout mice

2002 • 152 citations

Intrauterine Growth Retardation: Fetal Glucose Transport is Diminished in Lung but Spared in Brain

1992 • 129 citations

Functional Conservation of Regulatory Elements in the pdx-1 Gene: PDX-1 and Hepatocyte Nuclear Factor 3β Transcription Factors Mediate β-Cell-Specific Expression

2000 • 120 citations

Hormonal Regulation of an Islet-Specific Enhancer in the Pancreatic Homeobox Gene STF-1

1997 • 114 citations

A Pancreatic β-Cell-specific Enhancer in the HumanPDX-1 Gene Is Regulated by Hepatocyte Nuclear Factor 3β (HNF-3β), HNF-1α, and SPs Transcription Factors

2001 • 107 citations

Compensatory growth of pancreatic beta-cells in adult rats after short-term glucose infusion

1989 • 104 citations

Glucose-dependent Translocation of Insulin Promoter Factor-1 (IPF-1) between the Nuclear Periphery and the Nucleoplasm of Single MIN6 β-Cells

1998 • 100 citations

Glucose regulates glut 1 function and expression in fetal rat lung and muscle in vitro.

1993 • 40 citations

Measurement of GLUT mRNA in Liver of Fetal and Neonatal Rats Using a Novel Method of Quantitative Polymerase Chain Reaction

1996 • 27 citations

Glucagon-like Peptide 1 Increases Glucose-Dependent Activity of the Homeoprotein IDX-1 Transactivating Domain in Pancreatic β-Cells

2000 • 26 citations

Intrauterine Growth Retardation in the Rat Leads to Reduced Proliferation and Increased Apoptosis of the B-Cell

1999 • 2 citations