Direct regulation of the minichromosome maintenance complex by MYCN in neuroblastoma

Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

2002 • 18,672 citations

Purification of Mouse Immunoglobulin Heavy‐Chain Messenger RNAs from Total Myeloma Tumor RNA

1980 • 2,696 citations

c-Myc-regulated microRNAs modulate E2F1 expression

2005 • 2,371 citations

Revisions of the international criteria for neuroblastoma diagnosis, staging, and response to treatment.

1993 • 2,242 citations

Max: A Helix-Loop-Helix Zipper Protein That Forms a Sequence-Specific DNA-Binding Complex with Myc

1991 • 1,650 citations

Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour

1983 • 1,407 citations

Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion

2000 • 830 citations

Inhibition of Eukaryotic DNA Replication by Geminin Binding to Cdt1

2000 • 689 citations

Myc suppression of the p21Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage

2002 • 676 citations

Preventing re-replication of chromosomal DNA

2005 • 648 citations

Drosophila myc Regulates Cellular Growth during Development

1999 • 637 citations

MCM Proteins in DNA Replication

1999 • 635 citations

Association of Myn, the murine homolog of Max, with c-Myc stimulates methylation-sensitive DNA binding and ras cotransformation

1991 • 576 citations

Repression of p15INK4b expression by Myc through association with Miz-1

2001 • 571 citations

Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control

2004 • 552 citations

A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells

2003 • 524 citations

Identification of CDK4 as a target of c-MYC

2000 • 457 citations

N-myc enhances the expression of a large set of genes functioning in ribosome biogenesis and protein synthesis

2001 • 428 citations

Initiation of Eukaryotic DNA Replication

2000 • 408 citations

Binding of myc proteins to canonical and noncanonical DNA sequences.

1993 • 375 citations

Myc and the cell cycle

1998 • 360 citations

Sensitivity and accuracy of quantitative real-time polymerase chain reaction using SYBR green I depends on cDNA synthesis conditions

2002 • 335 citations

Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases

2004 • 327 citations

N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation

2000 • 322 citations

Differential modulation of cyclin gene expression by MYC.

1993 • 321 citations

The transcriptional program of a human B cell line in response to Myc

2001 • 312 citations

Conditional expression of N-myc in human neuroblastoma cells increases expression of alpha-prothymosin and ornithine decarboxylase and accelerates progression into S-phase early after mitogenic stimulation of quiescent cells.

1996 • 307 citations

N-myc amplification causes down-modulation of MHC class I antigen expression in neuroblastoma

1986 • 297 citations

Cdc7p-Dbf4p kinase binds to chromatin during S phase and is regulated by both the APC and the RAD53 checkpoint pathway

1999 • 267 citations

Identification of a Myc-dependent step during the formation of active G1 cyclin-cdk complexes.

1995 • 243 citations

Myc activation of cyclin E/Cdk2 kinase involves induction of cyclin E gene transcription and inhibition of p27Kip1 binding to newly formed complexes

1997 • 226 citations

Mcm10 Regulates the Stability and Chromatin Association of DNA Polymerase-α

2004 • 219 citations

Identification of Positively and Negatively Acting Elements Regulating Expression of the E2F2 Gene in Response to Cell Growth Signals

1997 • 211 citations

Myc-induced proliferation and transformation require Akt-mediated phosphorylation of FoxO proteins

2004 • 205 citations

Paradoxes of eukaryotic DNA replication: MCM proteins and the random completion problem

2003 • 197 citations

N-Myc gene amplification is a major prognostic factor in localized neuroblastoma: results of the French NBL 90 study. Neuroblastoma Study Group of the Société Francaise d'Oncologie Pédiatrique.

1997 • 182 citations

The role of c-myc in regulation of translation initiation

2004 • 165 citations

Xenopus Cdc7 function is dependent on licensing but not on XORC, XCdc6, or CDK activity and is required for XCdc45 loading

2000 • 159 citations

Eukaryotic DNA replication: from pre-replication complex to initiation complex

2000 • 146 citations

Cell growth-regulated expression of mammalian MCM5 and MCM6 genes mediated by the transcription factor E2F

1999 • 144 citations

MCM8 Is an MCM2-7-Related Protein that Functions as a DNA Helicase during Replication Elongation and Not Initiation

2005 • 141 citations

Loss of a FYN-regulated differentiation and growth arrest pathway in advanced stage neuroblastoma

2002 • 138 citations

Phosphorylation of MCM4 by cdc2 protein kinase inhibits the activity of the minichromosome maintenance complex.

1996 • 126 citations

Metastasis-associated protein 1 (MTA1) is an essential downstream effector of the c-MYC oncoprotein

2005 • 119 citations

Regulation of Geminin and Cdt1 expression by E2F transcription factors

2004 • 101 citations

Identification and functional characterization of a new member of the human Mcm protein family: hMcm8

2003 • 97 citations

Inhibition of Mcm4,6,7 Helicase Activity by Phosphorylation with Cyclin A/Cdk2

2000 • 90 citations

Mcm10 and Cdc45 Cooperate in Origin Activation in Saccharomyces cerevisiae

2004 • 88 citations

Minichromosome maintenance protein MCM7 is a direct target of the MYCN transcription factor in neuroblastoma.

2002 • 87 citations

Inverse regulation of cyclin B1 by c-Myc and p53 and induction of tetraploidy by cyclin B1 overexpression.

2001 • 86 citations

Cell Cycle- and Chromatin Binding State-dependent Phosphorylation of Human MCM Heterohexameric Complexes

1998 • 84 citations

Inhibition of a New Differentiation Pathway in Neuroblastoma by Copy Number Defects of N-myc, Cdc42, and nm23 Genes

2005 • 83 citations

The N-myc and c-myc downstream pathways include the chromosome 17q genes nm23-H1 and nm23-H2

2002 • 78 citations

Rearrangements and increased expression of cyclin D1 (CCND1) in neuroblastoma

2003 • 72 citations

A DNA microarray screen for genes involved in c-MYC and N-MYC oncogenesis in human tumors

2001 • 62 citations

The ATPase activity of MCM2–7 is dispensable for pre-RC assembly but is required for DNA unwinding

2005 • 52 citations

Modulation of N-myc expression alters the invasiveness of neuroblastoma.

1997 • 50 citations

DNA replication in vertebrates requires a homolog of the Cdc7 protein kinase

1999 • 42 citations

Selective induction of cell cycle regulatory genes cdk1 (p34^cdc2), cyclins a/b, and the tumor suppressor gene RB in transformed cells by okadaic acid

1995 • 35 citations

Upstream stimulatory factor activates the vasopressin promoter via multiple motifs, including a non-canonical E-box

2003 • 31 citations