Inactivation of CDK2 is synthetically lethal to MYCN over-expressing cancer cells

Cancer Cell Cycles

1996 • 5,379 citations

Neuroblastoma

2007 • 1,855 citations

A small molecule–kinase interaction map for clinical kinase inhibitors

2005 • 1,854 citations

To cycle or not to cycle: a critical decision in cancer

2001 • 1,429 citations

Biochemical and Cellular Effects of Roscovitine, a Potent and Selective Inhibitor of the Cyclin‐Dependent Kinases cdc2, cdk2 and cdk5

1997 • 1,324 citations

The Concept of Synthetic Lethality in the Context of Anticancer Therapy

2005 • 1,324 citations

Distinct Roles for Cyclin-Dependent Kinases in Cell Cycle Control

1993 • 1,096 citations

Living with or without cyclins and cyclin-dependent kinases

2004 • 1,047 citations

Cyclin-Dependent Kinase Pathways As Targets for Cancer Treatment

2006 • 984 citations

Cdk1 is sufficient to drive the mammalian cell cycle

2007 • 982 citations

Induction of an interferon response by RNAi vectors in mammalian cells

2003 • 972 citations

Regeneration of Peroxiredoxins by p53-Regulated Sestrins, Homologs of Bacterial AhpD

2004 • 702 citations

Specific inhibition of gene expression using a stably integrated, inducible small‐interfering‐RNA vector

2003 • 510 citations

Proliferation of cancer cells despite CDK2 inhibition

2003 • 458 citations

N-myc enhances the expression of a large set of genes functioning in ribosome biogenesis and protein synthesis

2001 • 428 citations

Cyclin E-induced S phase without activation of the pRb/E2F pathway.

1997 • 381 citations

Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC

2007 • 305 citations

Analysis of genomic targets reveals complex functions of MYC

2004 • 296 citations

The ferredoxin reductase gene is regulated by the p53 family and sensitizes cells to oxidative stress-induced apoptosis

2002 • 190 citations

Small Interfering RNA Screens Reveal Enhanced Cisplatin Cytotoxicity in Tumor Cells Having both BRCA Network and TP53 Disruptions

2006 • 179 citations

The p53 pathway and its inactivation in neuroblastoma

2003 • 166 citations

Cyclin D1 and CDK4 Activity Contribute to the Undifferentiated Phenotype in Neuroblastoma

2008 • 165 citations

Transcription-independent functions of MYC: regulation of translation and DNA replication

2008 • 152 citations

Pediatric neuroblastomas: genetic and epigenetic ‘Danse Macabre’

2003 • 140 citations

The Oscar-worthy role of Myc in apoptosis

2006 • 129 citations

Disruption of the cyclin D/cyclin-dependent kinase/INK4/retinoblastoma protein regulatory pathway in human neuroblastoma.

1998 • 78 citations

Rearrangements and increased expression of cyclin D1 (CCND1) in neuroblastoma

2003 • 72 citations

CYFIP2, a Direct p53 Target, is Leptomycin-B Sensitive

2007 • 52 citations

Identification of two distinct chromosome 12-derived amplification units in neuroblastoma cell line NGP

1995 • 50 citations

Direct regulation of the minichromosome maintenance complex by MYCN in neuroblastoma

2007 • 46 citations

p53 is Nuclear and Functional in Both Undifferentiated and Differentiated Neuroblastoma

2007 • 43 citations

Emerging Uses for Genomic Information in Drug Discovery

1998 • 30 citations

Lack of class I HLA expression in neuroblastoma is associated with high N-myc expression and hypomethylation due to loss of the MEMO-1 locus.

1996 • 28 citations

The direct p53 target gene, FLJ11259/DRAM, is a member of a novel family of transmembrane proteins

2007 • 27 citations

Myeloid ecotropic viral integration site 1 (MEIS) 1 involvement in embryonic implantation

2008 • 25 citations