Parkinsonian Mimetics Induce Aspects of Unfolded Protein Response in Death of Dopaminergic Neurons

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

1997 • 7,814 citations

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

1998 • 5,063 citations

Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

1983 • 4,822 citations

Coupling of Stress in the ER to Activation of JNK Protein Kinases by Transmembrane Protein Kinase IRE1

2000 • 2,831 citations

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

2002 • 2,702 citations

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

2000 • 2,696 citations

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

2000 • 1,975 citations

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

1998 • 1,972 citations

Gadd153 Sensitizes Cells to Endoplasmic Reticulum Stress by Down-Regulating Bcl2 and Perturbing the Cellular Redox State

2001 • 1,840 citations

Apoptosis Signaling

2000 • 1,290 citations

Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease

2001 • 1,210 citations

An Unfolded Putative Transmembrane Polypeptide, which Can Lead to Endoplasmic Reticulum Stress, Is a Substrate of Parkin

2001 • 1,048 citations

IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response

2002 • 1,031 citations

The Fas Signaling Pathway: More Than a Paradigm

2002 • 916 citations

An Endoplasmic Reticulum Stress-specific Caspase Cascade in Apoptosis

2002 • 875 citations

Activation of Caspase-12, an Endoplastic Reticulum (ER) Resident Caspase, through Tumor Necrosis Factor Receptor-associated Factor 2-dependent Mechanism in Response to the ER Stress

2001 • 832 citations

The machinery of programmed cell death

2001 • 830 citations

Two Distinct Stress Signaling Pathways Converge Upon the CHOP Promoter During the Mammalian Unfolded Protein Response

2002 • 666 citations

Experimental models of Parkinson's disease

2001 • 617 citations

The unfolded protein response in nutrient sensing and differentiation

2002 • 592 citations

Diverse functions of JNK signaling and c-Jun in stress response and apoptosis

1999 • 516 citations

Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response

2002 • 508 citations

Coupling Endoplasmic Reticulum Stress to the Cell Death Program

2002 • 480 citations

CHIP Is Associated with Parkin, a Gene Responsible for Familial Parkinson's Disease, and Enhances Its Ubiquitin Ligase Activity

2002 • 470 citations

Cytotoxic and genotoxic potential of dopamine

1999 • 465 citations

The Unfolding Tale of the Unfolded Protein Response

2001 • 398 citations

Distinct Mechanisms Underlie Neurotoxin-Mediated Cell Death in Cultured Dopaminergic Neurons

1999 • 393 citations

Conjugates of Catecholamines with Cysteine and GSH in Parkinson's Disease: Possible Mechanisms of Formation Involving Reactive Oxygen Species

1998 • 366 citations

CHOP (GADD153) and its oncogenic variant, TLS-CHOP, have opposing effects on the induction of G1/S arrest.

1994 • 331 citations

NF-κB Activation Is a Critical Regulator of Human Granulocyte Apoptosis in Vitro

1999 • 329 citations

Mitochondrial dysfunction and oxidative stress in aging and neurodegenerative disease

2000 • 300 citations

Impairment of the ubiquitin‐proteasome system causes dopaminergic cell death and inclusion body formation in ventral mesencephalic cultures

2002 • 297 citations

Molecular genetic analysis of a novel Parkin gene in Japanese families with autosomal recessive juvenile parkinsonism: Evidence for variable homozygous deletions in the Parkin gene in affected individuals

1998 • 293 citations

Proteasome inhibition causes nigral degeneration with inclusion bodies in rats

2002 • 264 citations

Neuronal cell death: a demise with different shapes

1999 • 258 citations

Two distinct mechanisms are involved in 6-hydroxydopamine- and MPP+-induced dopaminergic neuronal cell death: Role of caspases, ROS, and JNK

1999 • 256 citations

Dopaminergic cell death induced by MPP⁺, oxidant and specific neurotoxicants shares the common molecular mechanism

2001 • 251 citations

Case-control study of the ubiquitin carboxy-terminal hydrolase L1 gene in Parkinson’s disease

1999 • 214 citations

Immortalization of embryonic mesencephalic dopaminergic neurons by somatic cell fusion

1991 • 213 citations

Occurrence and distribution of 5-S-cysteinyl derivatives of dopamine, dopa and dopac in the brains of eight mammalian species

1986 • 152 citations

MPTP

2002 • 136 citations

Mass fragmentography of dopamine and 6-hydroxydopamine

1974 • 135 citations

Caspases Mediate Tumor Necrosis Factor-–Induced Neutrophil Apoptosis and Downregulation of Reactive Oxygen Production

1999 • 126 citations

Apoptotic molecules and MPTP-induced cell death

2002 • 119 citations

Organization and expression of the Rat D2A receptor gene: identification of alternative transcripts and a variant donor splice site

1990 • 109 citations

Caspases Mediate Tumor Necrosis Factor-–Induced Neutrophil Apoptosis and Downregulation of Reactive Oxygen Production

1999 • 97 citations

Amino acid limitation regulates CHOP expression through a specific pathway independent of the unfolded protein response

1999 • 87 citations

Identification of JNK‐dependent and ‐independent components of cerebellar granule neuron apoptosis

2002 • 78 citations

A ligand-receptor pair that triggers a non-apoptotic form of programmed cell death

2002 • 72 citations

Genetics of Parkinson's disease and biochemical studies of implicated gene products: Commentary

2002 • 67 citations

The growth arrest genes gas5, gas6, and CHOP-10 (gadd153) are expressed in the mouse preimplantation embryo

1997 • 60 citations

Broad-spectrum caspase inhibition paradoxically augments cell death in TNF-α–stimulated neutrophils

2002 • 59 citations

Overexpression of Bcl-2 attenuates MPP+, but not 6-ODHA, induced cell death in a dopaminergic neuronal cell line

1995 • 57 citations

Characterization of MPP+-Induced Cell Death in a Dopaminergic Neuronal Cell Line: Role of Macromolecule Synthesis, Cytosolic Calcium, Caspase, and Bcl-2-Related Proteins

1999 • 51 citations

Specific up‐regulation of GADD153/CHOP in 1‐methyl‐4‐phenyl‐pyridinium‐treated SH‐SY5Y cells

2002 • 34 citations

Genes associated with pro-apoptotic and protective mechanisms are affected differently on exposure of neuronal cell cultures to arsenite. No indication for endoplasmic reticulum stress despite activation of grp78 and gadd153 expression

2002 • 24 citations