Protective effect against Parkinson's disease-related insults through the activation of XBP1

Efficient selection for high-expression transfectants with a novel eukaryotic vector

1991 • 5,120 citations

Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

1983 • 4,822 citations

XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor

2001 • 3,799 citations

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

2000 • 3,559 citations

Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1

2004 • 3,278 citations

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

1999 • 3,119 citations

Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells

2000 • 3,071 citations

Coupling of Stress in the ER to Activation of JNK Protein Kinases by Transmembrane Protein Kinase IRE1

2000 • 2,831 citations

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

2002 • 2,702 citations

XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

2003 • 1,979 citations

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

2000 • 1,975 citations

ER Stress Induces Cleavage of Membrane-Bound ATF6 by the Same Proteases that Process SREBPs

2000 • 1,764 citations

MITOCHONDRIAL COMPLEX I DEFICIENCY IN PARKINSON'S DISEASE

1989 • 1,717 citations

The substantia nigra of the human brain

1999 • 1,598 citations

ETIOLOGY AND PATHOGENESIS OF PARKINSON'S DISEASE

1999 • 1,387 citations

A trip to the ER: coping with stress

2003 • 1,330 citations

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

2002 • 1,296 citations

ER stress and diseases

2007 • 1,043 citations

IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response

2002 • 1,031 citations

Cellular Defenses against Unfolded Proteins

2001 • 979 citations

Transcriptional Induction of Mammalian ER Quality Control Proteins Is Mediated by Single or Combined Action of ATF6α and XBP1

2007 • 976 citations

Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response

2004 • 928 citations

ER stress and neurodegenerative diseases

2006 • 822 citations

The UCH-L1 Gene Encodes Two Opposing Enzymatic Activities that Affect α-Synuclein Degradation and Parkinson's Disease Susceptibility

2002 • 768 citations

Proteasome inhibitors disrupt the unfolded protein response in myeloma cells

2003 • 597 citations

Endoplasmic Reticulum Stress and the Unfolded Protein Response in Cellular Models of Parkinson's Disease

2002 • 566 citations

Altered Proteasomal Function in Sporadic Parkinson's Disease

2002 • 565 citations

Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease

2004 • 531 citations

Activation of the unfolded protein response in Parkinson’s disease

2007 • 469 citations

The pathogenesis of cell death in Parkinson's disease

2006 • 432 citations

Parkinsonian Mimetics Induce Aspects of Unfolded Protein Response in Death of Dopaminergic Neurons

2003 • 366 citations

Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation

2006 • 360 citations

Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity

2005 • 355 citations

Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease

2003 • 299 citations

CHOP/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism

2005 • 281 citations

The cellular response to protein misfolding in the endoplasmic reticulum.

1999 • 210 citations

Differences in Nigral Neuron Number and Sensitivity to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine in C57/bl and CD-1 Mice

1994 • 140 citations

Postmortem changes in mitochondrial respiratory enzymes in brain and a preliminary observation in Parkinson's disease

1990 • 127 citations

Discordance of UPR signaling by ATF6 and Ire1p-XBP1 with levels of target transcripts

2004 • 90 citations

MPP⁺Induces the Endoplasmic Reticulum Stress Response in Rabbit Brain Involving Activation of the ATF-6 and NF-κB Signaling Pathways

2003 • 54 citations

A kinase inhibitor activates the IRE1α RNase to confer cytoprotection against ER stress

2007 • 52 citations

Salsolinol Causing Parkinsonism Activates Endoplasmic Reticulum-Stress Signaling Pathways in Human Dopaminergic SK-N-SH Cells

2003 • 19 citations