DNA multi-CTL epitope vaccines for HIV and Plasmodium falciparum: immunogenicity in mice

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs

1987 • 5,139 citations

Heterologous Protection Against Influenza by Injection of DNA Encoding a Viral Protein

1993 • 2,330 citations

Genetic immunization is a simple method for eliciting an immune response

1992 • 1,505 citations

DNA vaccines: protective immunizations by parenteral, mucosal, and gene-gun inoculations.

1993 • 1,122 citations

Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure.

1987 • 949 citations

HIV-specific cytotoxic T lymphocytes in seropositive individuals

1987 • 797 citations

Molecular analysis of the association of HLA-B53 and resistance to severe malaria

1992 • 645 citations

Intradermal gene immunization: the possible role of DNA uptake in the induction of cellular immunity to viruses.

1994 • 550 citations

AIDS virus-specific cytotoxic T lymphocytes in lung disorders

1987 • 539 citations

Cloned cytotoxic T cells recognize an epitope in the circumsporozoite protein and protect against malaria

1989 • 505 citations

Manipulation of the immune response to a plasmid-encoded viral antigen by coinoculation with plasmids expressing cytokines

1995 • 486 citations

Quantitative analysis of the human immunodeficiency virus type 1 (HIV-1)-specific cytotoxic T lymphocyte (CTL) response at different stages of HIV-1 infection: differential CTL responses to HIV-1 and Epstein-Barr virus in late disease.

1993 • 427 citations

HIV-specific cytotoxic T-cell activity in an HIV-exposed but uninfected infant

1993 • 368 citations

Quantification of antigen specific CD8+ T cells using an ELISPOT assay

1995 • 367 citations

Genetic immunization against herpes simplex virus. Protection is mediated by CD4+ T lymphocytes.

1995 • 333 citations

Plasmid DNA Is Superior to Viral Vectors for Direct Gene Transfer into Adult Mouse Skeletal Muscle

1993 • 314 citations

Efficient processing of an antigenic sequence for presentation by MHC class I molecules depends on its neighboring residues in the protein

1991 • 303 citations

Practical, biochemical and evolutionary implications of the discovery of HLA class I supermotifs

1996 • 263 citations

Longitudinal analysis of T cell receptor (TCR) gene usage by human immunodeficiency virus 1 envelope-specific cytotoxic T lymphocyte clones reveals a limited TCR repertoire.

1994 • 232 citations

Immune responses in HIV-exposed seronegatives: have they repelled the virus?

1995 • 181 citations

A "string-of-beads" vaccine, comprising linked minigenes, confers protection from lethal-dose virus challenge

1993 • 176 citations

Construction of solid matrix-antibody-antigen complexes containing simian immunodeficiency virus p27 using tag-specific monoclonal antibody and tag-linked antigen

1992 • 150 citations

DNA-Mediated Immunization in Mice Induces a Potent MHC Class I-Restricted Cytotoxic T Lymphocyte Response to the Hepatitis B Envelope Protein

1995 • 142 citations

Minimal epitopes expressed in a recombinant polyepitope protein are processed and presented to CD8+ cytotoxic T cells: implications for vaccine design.

1995 • 142 citations

Induction of CD8⁺ cytotoxic T lymphocytes by immunization with syngeneic irradiated HIV-1 envelope derived peptide-pulsed dendritic cells

1993 • 138 citations

CD8+ T cell recognition of an endogenously processed epitope is regulated primarily by residues within the epitope.

1992 • 79 citations

Vaccination to prevent persistent viral infection

1993 • 73 citations

Presentation of viral antigen to class I major histocompatibility complex-restricted cytotoxic T lymphocyte. Recognition of an immunodominant influenza hemagglutinin site by cytotoxic T lymphocyte is independent of the position of the site in the hemagglutinin translation product.

1991 • 58 citations

Induction of antibodies to a kappa V region by gene immunization.

1993 • 56 citations

DNA‐Mediated Immunization to the Hepatitis B Surface Antigen

1995 • 46 citations

Recognition of oligonucleotide-encoded T cell epitopes introduced into a gene unrelated to the original antigen.

1989 • 43 citations

An HLA-based approach to the design of a CTL-inducing vaccine against Plasmodium falciparum

1994 • 31 citations

Expression and Purification of Nonglycosylated SIV Proteins, and Their Use in Induction and Detection of SIV-Specific Immune Responses

1994 • 15 citations

Cytotoxic T lymphocytes and immune surveillance.

1992 • 13 citations

Attachment of an oligopeptide epitope to the C-terminus of recombinant SIV gp160 facilitates the construction of SMAA complexes while preserving CD4 binding

1995 • 9 citations

Two-tag purification of recombinant proteins for the construction of solid matrix-antibody-antigen (SMAA) complexes as vaccines

1993 • 9 citations