From head to toes: the multiple facets of Sox proteins

A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif

1990 • 3,134 citations

Male development of chromosomally female mice transgenic for Sry

1991 • 2,157 citations

A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes

1990 • 1,630 citations

A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation

1994 • 1,604 citations

Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY-related gene

1994 • 1,573 citations

Autosomal sex reversal and campomelic dysplasia are caused by mutations in and around the SRY-related gene SOX9

1994 • 1,521 citations

SOX9 Is a Potent Activator of the Chondrocyte-Specific Enhancer of the Proα1(II) Collagen Gene

1997 • 1,051 citations

Genetic evidence equating SRY and the testis-determining factor

1990 • 972 citations

SOX9 directly regulates the type-ll collagen gene

1997 • 891 citations

Expression of a candidate sex-determining gene during mouse testis differentiation

1990 • 834 citations

Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP

1994 • 807 citations

SOX10 mutations in patients with Waardenburg-Hirschsprung disease

1998 • 806 citations

A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene

1998 • 792 citations

Sox9 expression during gonadal development implies a conserved role for the gene in testis differentiation in mammals and birds

1996 • 788 citations

Sox10, a Novel Transcriptional Modulator in Glial Cells

1998 • 759 citations

Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3.

1995 • 744 citations

SOX10 mutation disrupts neural crest development in Dom Hirschsprung mouse model

1998 • 725 citations

A male-specific role forSOX9in vertebrate sex determination

1996 • 690 citations

SOX9 Binds DNA, Activates Transcription, and Coexpresses with Type II Collagen during Chondrogenesis in the Mouse

1997 • 665 citations

The Sry-related gene Sox9 is expressed during chondrogenesis in mouse embryos

1995 • 648 citations

Direct Interaction of SRY-Related Protein SOX9 and Steroidogenic Factor 1 Regulates Transcription of the Human Anti-Müllerian Hormone Gene

1998 • 578 citations

Expression of Sry, the mouse sex determining gene

1995 • 559 citations

Dax1 antagonizes Sry action in mammalian sex determination

1998 • 556 citations

A comparison of the properties ofSox-3withSryand two related genes,Sox-1andSox-2

1996 • 485 citations

POU domain family values: flexibility, partnerships, and developmental codes.

1997 • 481 citations

Sox genes find their feet

1997 • 478 citations

A role for SOX1 in neural determination

1998 • 470 citations

Molecular basis of human 46X,Y sex reversal revealed from the three-dimensional solution structure of the human SRY-DNA complex

1995 • 469 citations

Defects in cardiac outflow tract formation and pro-B-lymphocyte expansion in mice lacking Sox-4

1996 • 464 citations

Xenopus Zic-related-1 and Sox-2, two factors induced by chordin, have distinct activities in the initiation of neural induction

1998 • 460 citations

SRY, like HMG1, recognizes sharp angles in DNA.

1992 • 439 citations

A human XY female with a frame shift mutation in the candidate testis-determining gene SRY

1990 • 409 citations

Embryonic expression of the chicken Sox2, Sox3 and Sox11 genes suggests an interactive role in neuronal development

1995 • 388 citations

Definition of a consensus DNA binding site for SRY

1994 • 381 citations

Synergistic Activation of the Fibroblast Growth Factor 4 Enhancer by Sox2 and Oct-3 Depends on Protein-Protein Interactions Facilitated by a Specific Spatial Arrangement of Factor Binding Sites

1997 • 372 citations

Mutation of the Sry-related Sox10 gene in Dominant megacolon , a mouse model for human Hirschsprung disease

1998 • 354 citations

Xsox17α and -β Mediate Endoderm Formation in Xenopus

1997 • 354 citations

Sox-4, an Sry-like HMG box protein, is a transcriptional activator in lymphocytes.

1993 • 340 citations

Ancestry and diversity of the HMG box superfamily

1993 • 328 citations

Involvement ofSox1, 2and3in the early and subsequent molecular events of lens induction

1998 • 325 citations

New POU dimer configuration mediates antagonistic control of an osteopontin preimplantation enhancer by Oct-4 and Sox-2

1998 • 313 citations

XY female mice resulting from a heritable mutation in the primary testis determining gene, Tdy

1990 • 304 citations

Sex-reversing mutations affect the architecture of SRY-DNA complexes.

1994 • 291 citations

TCF/LEF factors earn their wings

1997 • 288 citations

Sox1 directly regulates the gamma -crystallin genes and is essential for lens development in mice

1998 • 281 citations

An SRY-related sequence on the marsupial X chromosome:implications for the evolution of the mammalian testis-determininggene.

1994 • 278 citations

An SRY-related gene expressed during spermatogenesis in the mouse encodes a sequence-specific DNA-binding protein.

1992 • 260 citations

POU-domain proteins: structure and function of developmental regulators

1993 • 251 citations

SOX3 is an X-linked gene related to SRY

1993 • 250 citations

Involvement of SOX proteins in lens-specific activation of crystallin genes.

1995 • 237 citations

Cooperative Function of POU Proteins and SOX Proteins in Glial Cells

1998 • 226 citations

Dynamic expression of chicken Sox2 and Sox3 genes in ectoderm induced to form neural tissue

1997 • 226 citations

Seven new members of theSoxgene family expressed during mouse development

1993 • 211 citations

Sex reversal by loss of the C–terminal transactivation domain of human SOX9

1996 • 208 citations

Mixer , a Homeobox Gene Required for Endoderm Development

1998 • 206 citations

Mutational analysis of the SOX9 gene in campomelic dysplasia and autosomal sex reversal: lack of genotype/phenotype correlations

1997 • 201 citations

DNA-binding properties of the product of the testis-determining gene and a related protein

1991 • 200 citations

Identification of two Sox17 messenger RNA isoforms, with and without the high mobility group box region, and their differential expression in mouse spermatogenesis.

1996 • 193 citations

Early expression ofAMH in chicken embryonic gonads precedes testicularSOX9 expression

1998 • 188 citations

Architectural Transcription Factors

1994 • 187 citations

Characterization and early embryonic expression of a neural specific transcription factor xSOX3 in Xenopus laevis.

1997 • 181 citations

Expression of a linear Sry transcript in the mouse genital ridge

1995 • 177 citations

Two Independent Nuclear Localization Signals Are Present in the DNA-binding High-mobility Group Domains of SRY and SOX9

1997 • 176 citations

Three High Mobility Group-like Sequences within a 48-Base Pair Enhancer of the Col2a1 Gene Are Required for Cartilage-specific Expression in Vivo

1998 • 168 citations

Preventing the loss of competence for neural induction: HGF/SF, L5 and Sox-2

1997 • 162 citations

Deletion of long-range regulatory elements upstream of SOX9 causes campomelic dysplasia

1998 • 158 citations

The Human Testis Determining Factor SRY Binds a Nuclear Factor Containing PDZ Protein Interaction Domains

1997 • 157 citations

A conserved family of genes related to the testis determining gene,SRY

1992 • 148 citations

TCF: transcriptional activator or repressor?

1998 • 144 citations

TheSry-related HMG box-containing geneSox6is expressed in the adult testis and developing nervous system of the mouse

1995 • 144 citations

DNA binding and bending properties of the postmeiotically expressed Sry-related protein Sox-5

1994 • 144 citations

The Dichaete gene of Drosophila melanogaster encodes a SOX-domain protein required for embryonic segmentation

1996 • 142 citations

Functional Analysis of Sox10 Mutations Found in Human Waardenburg-Hirschsprung Patients

1998 • 136 citations

The SOX10 / Sox10 gene from human and mouse: sequence, expression, and transactivation by the encoded HMG domain transcription factor

1998 • 133 citations

SoxD

1998 • 130 citations

Architectural Transcription Factors: Proteins That-Remodel DNA

1997 • 129 citations

Expression of theSox11 gene in mouse embryos suggests roles in neuronal maturation and epithelio-mesenchymal induction

1997 • 127 citations

Sry is a transcriptional activator.

1994 • 123 citations

Nuclear localization of the testis determining gene product SRY.

1995 • 119 citations

The Drosophila fish-hook gene encodes a HMG domain protein essential for segmentation and CNS development

1996 • 118 citations

Expression of the SOX10 gene during human development

1998 • 110 citations

The Drosophila SOX-domain protein Dichaete is required for the development of the central nervous system midline

1998 • 106 citations

Sox‐4 facilitates thymocyte differentiation

1997 • 105 citations

The cDNA sequence and chromosomal location of the human SOX2 gene

1994 • 100 citations

SOX Genes: Architects of Development

1996 • 99 citations

Translocation breakpoints in three patients with campomelic dysplasia and autosomal sex reversal map more than 130 kb from SOX9

1996 • 96 citations

Phosphorylation of an N-terminal Motif Enhances DNA-binding Activity of the Human SRY Protein

1998 • 84 citations

Mutational analysis ofSRY in XY females

1993 • 84 citations

The Human SOX11 Gene: Cloning, Chromosomal Assignment and Tissue Expression

1995 • 84 citations

Cloning and Characterization ofSOX5,a New Member of the HumanSOXGene Family

1996 • 82 citations

Human Testis-Determining Factor SRY Binds to the Major DNA Adduct of Cisplatin and a Putative Target Sequence with Comparable Affinities

1998 • 80 citations

Solution Structure of the Sequence-specific HMG Box of the Lymphocyte Transcriptional Activator Sox-4

1995 • 73 citations

Rainbow trout SOX9: cDNA cloning, gene structure and expression

1997 • 71 citations

A Gene That Is Related to SRY and Is Expressed in the Testes Encodes a Leucine Zipper-Containing Protein

1995 • 69 citations

Gene regulatory functions of Drosophila Fish-hook, a high mobility group domain Sox protein

1998 • 56 citations

Sequence and expression of Sox-18 encoding a new HMG-box transcription factor

1995 • 53 citations

cSox21 exhibits a complex and dynamic pattern of transcription during embryonic development of the chick central nervous system

1997 • 52 citations

SOX22 is a new member of the SOX gene family, mainly expressed in human nervous tissue

1997 • 48 citations

High expression of the HMG box factor Sox-13 in arterial walls during embryonic development

1998 • 44 citations

The zebrafish Zf-Sox 19 protein: a novel member of the Sox family which reveals highly conserved motifs outside of the DNA-binding domain

1995 • 43 citations

An SRY Mutation Causing Human Sex Reversal Resolves a General Mechanism of Structure-Specific DNA Recognition: Application to the Four-Way DNA Junction

1995 • 41 citations

Isolation of a NovelSry-Related Gene That Is Expressed in High-Metastatic K-1735 Murine Melanoma Cells

1997 • 36 citations

Zygotic expression of the zebrafish Sox-19, an HMG box-containing gene, suggests an involvement in central nervous system development

1996 • 35 citations

A rainbow trout SRY-type gene expressed in pituitary glands

1995 • 34 citations

Cloning and characterization ofXenopus laevis xSox7 cDNA

1996 • 30 citations

XLS13A and XLS13B: SRY-related genes of Xenopus laevis

1997 • 30 citations

Rainbow trout Sox24, a novel member of the Sox family, is a transcriptional regulator during oogenesis

1998 • 30 citations

Cloning and mapping of the human SOX1: a highly conserved gene expressed in the developing brain

1997 • 28 citations

The mouse Sox5 gene encodes a protein containing the leucine zipper and the Q box

1998 • 24 citations

SOX20, a new member of the SOX gene family, is located on chromosome 17p13

1996 • 23 citations

Cloning and expression of Xenopus laevis xSox12 cDNA

1996 • 23 citations

Cloning and characterization of mouse mSox13 cDN

1998 • 22 citations

cDNA cloning of a novel rainbow trout SRY-type HMG box protein, rtSox23, and its functional analysis

1998 • 21 citations

SRY-related genes in Xenopus oocytes

1996 • 21 citations

Isolation and expression of a human SRY-related cDNA, hSOX20

1998 • 19 citations

Partial cloning of SOX-11 and SOX-12, two new human SOX genes

1993 • 15 citations

Nucleotide sequence of mouse Sry gene is different between Y chromosomes originating from Mus musculus musculus and Mus musculus domesticus

1992 • 15 citations

Numerous Members of the Sox Family of HMG Box-Containing Genes Are Expressed in Developing Mouse Teeth

1996 • 14 citations

The SRY protein, like HMG 1, recognizes (CA)n sequences, an abundant repeat sequence in vertebrates.

1995 • 8 citations