Molecular basis of human 46X,Y sex reversal revealed from the three-dimensional solution structure of the human SRY-DNA complex

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A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif

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Principles of Nucleic Acid Structure

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Transcriptional activation: A complex puzzle with few easy pieces

1994 • 1,112 citations

Crystal structure of a yeast TBP/TATA-box complex

1993 • 1,082 citations

Co-crystal structure of TBP recognizing the minor groove of a TATA element

1993 • 1,039 citations

Genetic evidence equating SRY and the testis-determining factor

1990 • 972 citations

Methodological Advances in Protein NMR

1993 • 721 citations

Defining the Structure of Irregular Nucleic Acids: Conventions and Principles

1989 • 704 citations

Methodological advances in protein NMR

1993 • 686 citations

The HMG domain of lymphoid enhancer factor 1 bends DNA and facilitates assembly of functional nucleoprotein structures

1992 • 684 citations

Determination of three‐dimensional structures of proteins from interproton distance data by dynamical simulated annealing from a random array of atoms Circumventing problems associated with folding

1988 • 546 citations

NMR Structure of a Specific DNA Complex of Zn-Containing DNA Binding Domain of GATA-1

1993 • 456 citations

DNA Binding Activity of Recombinant SRY from Normal Males and XY Females

1992 • 454 citations

SRY, like HMG1, recognizes sharp angles in DNA.

1992 • 439 citations

Structures of Larger Proteins in Solution: Three- and Four-Dimensional Heteronuclear NMR Spectroscopy

1991 • 437 citations

SRY AND SEX DETERMINATION IN MAMMALS

1993 • 422 citations

Structure of the HMG box motif in the B-domain of HMG1.

1993 • 403 citations

Rapid sequence evolution of the mammalian sex-determining gene SRY

1993 • 393 citations

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1994 • 389 citations

Definition of a consensus DNA binding site for SRY

1994 • 381 citations

Determination of Three-Dimensional Structures of Proteins and Nucleic Acids in Solution by Nuclear Magnetic Resonance Spectroscop

1989 • 342 citations

Ancestry and diversity of the HMG box superfamily

1993 • 328 citations

The nonspecific DNA-binding and -bending proteins HMG1 and HMG2 promote the assembly of complex nucleoprotein structures.

1993 • 327 citations

A calculation strategy for the structure determination of symmetric demers by ¹H NMR

1993 • 313 citations

Sex-reversing mutations affect the architecture of SRY-DNA complexes.

1994 • 291 citations

Solution structure of a DNA-binding domain from HMG1

1993 • 275 citations

Molecular basis of mammalian sexual determination: activation of Mullerian inhibiting substance gene expression by SRY

1994 • 260 citations

Mutational analysis of SRY: nonsense and missense mutations in XY sex reversal

1992 • 253 citations

Sequence-specific interaction of the HMG box proteins TCF-1 and SRY occurs within the minor groove of a Watson-Crick double helix.

1992 • 218 citations

Rapid evolution of the sex determining locus in Old World mice and rats

1993 • 215 citations

The Impact of Direct Refinement against 13Cα and 13Cβ Chemical Shifts on Protein Structure Determination by NMR

1995 • 204 citations

XY sex reversal associated with a deletion 5' to the SRY "HMG box" in the testis-determining region.

1992 • 181 citations

SRY recognizes conserved DNA sites in sex-specific promoters.

1993 • 151 citations

Evidence for increased prevalence of SRY mutations in XY females with complete rather than partial gonadal dysgenesis.

1992 • 149 citations

Architectural elements in nucleoprotein complexes: interchangeability of specific and non-specific DNA binding proteins.

1994 • 142 citations

The SRY high-mobility-group box recognizes DNA by partial intercalation in the minor groove: a topological mechanism of sequence specificity.

1993 • 137 citations

The Impact of Direct Refinement against Three-Bond HN-CαH Coupling Constants on Protein Structure Determination by NMR

1994 • 136 citations

Structures of larger proteins, protein‐ligand and protein‐DNA complexes by multidimensional heteronuclear NMR

1994 • 111 citations

Analysis of the SRY gene in 22 sex-reversed XY females identifies four new point mutations in the conserved DNA binding domain

1993 • 109 citations

The solution structure and dynamics of the DNA-binding domain of HMG-D from Drosophila melanogaster

1994 • 100 citations

True hermaphroditism in a 46,XY individual, caused by a postzygotic somatic point mutation in the male gonadal sex-determining locus (SRY): molecular genetics and histological findings in a sporadic case.

1993 • 93 citations

A novel mutation localized in the 3′ non-HMG box region of the SRY gene in 46, XY gonadal dysgenesis

1994 • 79 citations

The DNA sequence specificity of HMG boxes lies in the minor wing of the structure.

1994 • 70 citations

MALE SEX DETERMINATION: Current Concepts of Male Sexual Differentiation

1994 • 50 citations