Pulmonary irradiation-induced expression of VCAM-I and ICAM-I is decreased by manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) gene therapy

Nonparametric Statistical Methods

1999 • 6,387 citations

A Mechanism for Regulating Pulmonary Inflammation and Fibrosis: The Integrin αvβ6 Binds and Activates Latent TGF β1

1999 • 1,965 citations

A class of rank test procedures for censored survival data

1982 • 1,111 citations

Clinical Radiation Pathology

1968 • 930 citations

Radiobiology for the Radiologist

1988 • 807 citations

A perpetual cascade of cytokines postirradiation leads to pulmonary fibrosis

1995 • 641 citations

TGF-β1 and radiation fibrosis: a master switch and a specific therapeutic target?

2000 • 626 citations

Factors predicting severe radiation pneumonitis in patients receiving definitive chemoradiation for lung cancer

2000 • 292 citations

Transfer of Tumor Necrosis Factor-α to Rat Lung Induces Severe Pulmonary Inflammation and Patchy Interstitial Fibrogenesis with Induction of Transforming Growth Factor-β1 and Myofibroblasts

1998 • 263 citations

Plasma transforming growth factor β1 as a predictor of radiation pneumonitis

1998 • 236 citations

Physical and biological predictors of changes in whole-lung function following thoracic irradiation

1997 • 225 citations

Pulmonary Fibrosis and Chronic Lung Inflammation in ET-1 Transgenic Mice

2000 • 222 citations

Prevention of late effects of irradiation lung damage by manganese superoxide dismutase gene therapy

1998 • 179 citations

Early and persistent alterations in the expression of interleukin-1 alpha, interleukin-1 beta and tumor necrosis factor alpha mRNA levels in fibrosis-resistant and sensitive mice after thoracic irradiation.

1996 • 175 citations

A class of hypothesis tests for one and two sample censored survival data

1981 • 173 citations

Protective roles of cytokines against radiation: Induction of mitochondrial MnSOD

1995 • 172 citations

Intercellular adhesion molecule 1 knockout abrogates radiation induced pulmonary inflammation

1997 • 170 citations

Radiation-induced normal tissue injury: Role of adhesion molecules in leukocyte-endothelial cell interactions

1999 • 166 citations

Intratracheal injection of adenovirus containing the human MNSOD transgene protects athymic nude mice from irradiation-induced organizing alveolitis

1999 • 151 citations

Characterization of Matrix Metalloproteinases Produced by Rat Alveolar Macrophages

1999 • 144 citations

Essential Role of Alveolar Macrophages in Intrapulmonary Activation of NF- κ B

1999 • 128 citations

Modulation of Radiation-Induced Cytokine Elevation Associated with Esophagitis and Esophageal Stricture by Manganese Superoxide Dismutase-Plasmid/Liposome (SOD2-PL) Gene Therapy

2001 • 124 citations

Intratracheal injection of manganese superoxide dismutase (MnSOD) plasmid/liposomes protects normal lung but not orthotopic tumors from irradiation

2000 • 120 citations

Nitric Oxide Blocks Nuclear Factor- κ B Activation in Alveolar Macrophages

1999 • 119 citations

Manganese [correction of Magnesium] superoxide dismutase (MnSOD) plasmid/liposome pulmonary radioprotective gene therapy: Modulation of irradiation-induced mRNA for IL-I, TNF-alpha, and TGF-beta correlates with delay of organizing alveolitis/fibrosis

1999 • 116 citations

Role of Matrix Metalloproteinases in Models of Macrophage-Dependent Acute Lung Injury

1999 • 114 citations

Differences in Correlation of mRNA Gene Expression in Mice Sensitive and Resistant to Radiation-Induced Pulmonary Fibrosis

1995 • 103 citations

Different Expression of TNF- α Receptors and Prostaglandin E₂Production in Normal and Fibrotic Lung Fibroblasts

2000 • 94 citations

Decreased Pulmonary Radiation Resistance of Manganese Superoxide Dismutase (MnSOD)-Deficient Mice is Corrected by Human Manganese Superoxide Dismutase-Plasmid/Liposome (SOD2-PL) Intratracheal Gene Therapy

2000 • 93 citations

Fibroblast radiosensitivity in vitro and lung fibrosis in vivo: comparison between a fibrosis-prone and fibrosis-resistant mouse strain.

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Transgenic expression of granulocyte-macrophage colony-stimulating factor induces the differentiation and activation of a novel dendritic cell population in the lung

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Pulmonary Fibrosis

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Quantitative effect of combined chemotherapy and fractionated radiotherapy on the incidence of radiation-induced lung damage: A prospective clinical study

1994 • 71 citations

Changes in local pulmonary injury up to 48 months after irradiation for lymphoma and breast cancer

2000 • 70 citations

α9β1 Integrin is expressed on human neutrophils and contributes to neutrophil migration through human lung and synovial fibroblast barriers

1999 • 69 citations

Lung Fibrosis Induced by Silica Particles in NMRI Mice Is Associated with an Upregulation of the p40 Subunit of Interleukin-12 and Th-2 Manifestations

1999 • 68 citations

Fibronectin Gene Polymorphisms Associated with Fibrosing Alveolitis in Systemic Sclerosis

1999 • 66 citations

Development of Fibrosis after Lung Irradiation in Relation to Inflammation and Lung Function in a Mouse Strain Prone to Fibrosis

1994 • 65 citations

Role of tumor necrosis factor-alpha in the spontaneous development of pulmonary fibrosis in viable motheaten mutant mice.

1997 • 64 citations

Factors Influencing the Development of Lung Fibrosis after Chemoradiation for Small Cell Carcinoma of the Lung: Evidence for Inherent Interindividual Variation

1998 • 60 citations

Lack of IL-10 synthesis by murine alveolar macrophages upon lipopolysaccharide exposure. Comparison with peritoneal macrophages

2000 • 59 citations

Idiopathic Pneumonia Syndrome after Allogeneic Bone Marrow Transplantation in Mice

1999 • 53 citations

Overexpression of the human manganese superoxide dismutase (MnSOD) transgene in subclones of murine hematopoietic progenitor cell line 32D cl 3 decreases irradiation-induced apoptosis but does not alter G2/M or G1/S phase cell cycle arrest

1999 • 50 citations

Prospective evaluation of early lung toxicity following three-dimensional conformal radiation therapy in non–small-cell lung cancer: preliminary results

2000 • 49 citations

Sialyl Lewis X Mimetics Attenuate E-Selectin-Mediated Adhesion of Leukocytes to Irradiated Human Endothelial Cells

1997 • 45 citations

Intracellular oxidant production and cytokine responses in lung macrophages: evaluation of fluorescent probes

1999 • 44 citations

Overexpression of manganese superoxide dismutase (MnSOD) in whole lung or alveolar type II cells of MnSOD transgenic mice does not provide intrinsic lung irradiation protection

2001 • 30 citations

Mechanisms of Lung Injury after Bone Marrow Transplantation

1999 • 24 citations

A Role for Transforming Growth Factor-β1 in the Increased Pneumonitis in Murine Allogeneic Bone Marrow Transplant Recipients With Graft-Versus-Host Disease After Pulmonary Herpes Simplex Virus Type 1 Infection

1998 • 24 citations

Accessory cells with immunophenotypic and functional features of monocyte-derived dendritic cells are recruited to the lung during pulmonary inflammation

1999 • 18 citations

Bone Marrow-Derived Cells Are Required for the Induction of a Pulmonary Inflammatory Response Mediated by CD40 Ligation

1999 • 16 citations

Regulation of the processing and release of tumor necrosis factor α in a human macrophage cell line

1999 • 10 citations