Regulation of the processing and release of tumor necrosis factor α in a human macrophage cell line

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

An endotoxin-induced serum factor that causes necrosis of tumors.

1975 • 4,522 citations

A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells

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A matrix metalloproteinase expressed on the surface of invasive tumour cells

1994 • 2,561 citations

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-α

1997 • 1,608 citations

Tumor Cell Interactions with the Extracellular Matrix During Invasion and Metastasis

1993 • 1,523 citations

Processing of tumour necrosis factor-α precursor by metalloproteinases

1994 • 1,200 citations

Metalloproteinase-mediated release of human Fas ligand.

1995 • 835 citations

Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processing

1994 • 607 citations

Tumor necrosis factor.

1992 • 601 citations

Regulation of tumour necrosis factor-α processing by a metalloproteinase inhibitor

1994 • 571 citations

Diverse Cell Surface Protein Ectodomains Are Shed by a System Sensitive to Metalloprotease Inhibitors

1996 • 404 citations

Degranulation plays an essential part in regulating cell surface expression of Fas ligand in T cells and natural killer cells

1999 • 385 citations

A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts.

1993 • 383 citations

A metalloprotease inhibitor blocks shedding of the IL-6 receptor and the p60 TNF receptor.

1995 • 254 citations

A metalloprotease inhibitor blocks shedding of the 80-kD TNF receptor and TNF processing in T lymphocytes.

1995 • 234 citations

Metalloprotease and serine protease are involved in cleavage of CD43, CD44, and CD16 from stimulated human granulocytes. Induction of cleavage of L-selectin via CD16.

1994 • 160 citations

Paradoxical effects of a synthetic metalloproteinase inhibitor that blocks both p55 and p75 TNF receptor shedding and TNF alpha processing in RA synovial membrane cell cultures.

1996 • 121 citations

The Biology Of Cachectin/TNF: A Primary Mediator Of The Host Response

1989 • 115 citations

In Vitro Processing of Human Tumor Necrosis Factor-α

1995 • 114 citations

Myristyl acylation of the tumor necrosis factor alpha precursor on specific lysine residues.

1992 • 113 citations

Physiological enzymatic cleavage of leukocyte membrane molecules

1995 • 110 citations

Role of Calcium in Tumor Necrosis Factor- Production by Activated Macrophages

1996 • 99 citations

Processing of newly synthesized cachectin/tumor necrosis factor in endotoxin-stimulated macrophages

1990 • 86 citations

Relaxed Specificity of Matrix Metalloproteinases (MMPS) and TIMP Insensitivity of Tumor Necrosis Factor-α (TNF-α) Production Suggest the Major TNF-α Converting Enzyme Is Not an MMP

1996 • 69 citations

The fate of pro-TNF-alpha following inhibition of metalloprotease-dependent processing to soluble TNF-alpha in human monocytes.

1997 • 68 citations

Phosphorylation of intracellular precursors of human IL-1.

1988 • 57 citations

Phosphorylation of the 26 kDa TNF precursor in monocytic cells and in transfected HeLa cells.

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Abstract 134: Targeting NLMP prevents drug adaptive prostate cancer evolution

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Processing and release of tumor necrosis factor α

1998 • 29 citations

Tumor cytostasis mediated by LPS- or PSK-activated human plastic-adherent peripheral blood mononuclear cells

1992 • 8 citations

Comparison of Reactivity of Monoclonal Antibody (3F2) to Trimeric Tumor Necrosis Factor (TNF-α) with That to Monomeric TNF-α1

1995 • 7 citations