Low Dose Streptozotocin-Induced Diabetes in Rat Insulin Promoter-mCD80-Transgenic Mice Is T Cell Autoantigen-Specific and CD28 Dependent

The Role of the CD28 Receptor During T Cell Responses to Antigen

1993 • 1,320 citations

Differential T Cell Costimulatory Requirements in CD28-Deficient Mice

1993 • 1,271 citations

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

1991 • 1,187 citations

Streptozotocin-Induced Pancreatic Insulitis: New Model of Diabetes Mellitus

1976 • 972 citations

Signals and signs for lymphocyte responses

1994 • 868 citations

Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function.

1994 • 681 citations

Constitutive class I-restricted exogenous presentation of self antigens in vivo.

1996 • 637 citations

AN IMPROVED METHOD FOR ISOLATION OF MOUSE PANCREATIC ISLETS

1985 • 548 citations

Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers.

1995 • 481 citations

Absence of B7-dependent responses in CD28-deficient mice

1994 • 386 citations

Acceleration of Diabetes in Young Nod Mice with a CD4 ⁺ Islet-specific T Cell Clone

1990 • 385 citations

CD28/B7 Regulation of Th1 and Th2 Subsets in the Development of Autoimmune Diabetes

1996 • 379 citations

CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells.

1996 • 349 citations

Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7.

1991 • 349 citations

Self Antigens Expressed by Solid Tumors Do Not Efficiently Stimulate Naive or Activated T Cells: Implications for Immunotherapy

1997 • 316 citations

Functional expression of the costimulatory molecule, B7/BB1, on murine dendritic cell populations.

1992 • 306 citations

Studies of streptozotocin-induced insulitis and diabetes.

1977 • 262 citations

CD28 is required for germinal center formation.

1996 • 251 citations

T cell priming versus T cell tolerance induced by synthetic peptides.

1995 • 230 citations

Beta cell mass and growth after syngeneic islet cell transplantation in normal and streptozocin diabetic C57BL/6 mice.

1993 • 199 citations

Costimulator B7-1 confers antigen-presenting-cell function to parenchymal tissue and in conjunction with tumor necrosis factor alpha leads to autoimmunity in transgenic mice.

1994 • 188 citations

The role of the T cell costimulator B7-1 in autoimmunity and the induction and maintenance of tolerance to peripheral antigen

1994 • 181 citations

Coexpression of B7-1 and viral (“self”) transgenes in pancreatic β cells can break peripheral ignorance and lead to spontaneous autoimmune diabetes

1995 • 177 citations

Mice expressing both B7-1 and viral glycoprotein on pancreatic beta cells along with glycoprotein-specific transgenic T cells develop diabetes due to a breakdown of T-lymphocyte unresponsiveness.

1994 • 163 citations

Genetic Influence of the Streptozotocin-induced Insulitis and Hyperglycemia

1977 • 153 citations

Expression of a tumor necrosis factor alpha transgene in murine pancreatic beta cells results in severe and permanent insulitis without evolution towards diabetes.

1992 • 151 citations

Diabetogenic T-Cell Clones

1996 • 127 citations

Optimal lymphocytic choriomeningitis virus sequences restricted by H-2Db major histocompatibility complex class I molecules and presented to cytotoxic T lymphocytes

1995 • 121 citations

Genetic and physical mapping of a type 1 diabetes susceptibility gene (IDDM12) to a 100-kb phagemid artificial chromosome clone containing D2S72-CTLA4-D2S105 on chromosome 2q33.

2000 • 113 citations

Cytotoxic T lymphocyte activation by cross-priming

1999 • 108 citations

Single cell analyses of cytokine production

1997 • 102 citations

CD28-Deficient Mice Are Highly Resistant to Collagen-Induced Arthritis

1999 • 99 citations

SEX DIFFERENCES IN THE MULTIPLE-DOSE STREPTOZOTOCIN MODEL OF DIABETES1

1978 • 94 citations

SKIN ALLOGRAFT REJECTION IN CD28-DEFICIENT MICE1

1996 • 93 citations

CD28 Costimulation Is Crucial for the Development of Spontaneous Autoimmune Encephalomyelitis

1999 • 82 citations

CD28‐deficient mice generate an impaired Th2 response to Schistosoma mansoni infection

1996 • 77 citations

Measurement of Rat Insulin: Enzyme-Linked Immunosorbent Assay With Increased Sensitivity, High Accuracy, and Greater Practicability Than Established Radioimmunoassay

1988 • 73 citations

Protection against lethal toxic shock by targeted disruption of the CD28 gene.

1996 • 72 citations

Expression of the Co-stimulator Molecule B7–1 in Pancreatic β-Cells Accelerates Diabetes in the NOD Mouse

1995 • 67 citations

Inflammatory cytokines IFN-gamma plus TNF-alpha induce regulated expression of CD80 (B7-1) but not CD86 (B7-2) on murine fibroblasts.

1997 • 62 citations

Streptozotocin: Its excretion and metabolism in the rat

1976 • 61 citations

Uncovering subdominant cytotoxic T-lymphocyte responses in lymphocytic choriomeningitis virus-infected BALB/c mice

1997 • 58 citations

Relationship Among Immunodominance of Single CD8+ T Cell Epitopes, Virus Load, and Kinetics of Primary Antiviral CTL Response

1998 • 55 citations

Genetic influence of the streptozotocin-induced insulitis and hyperglycemia

1977 • 49 citations

Immunologic Studies on the Induction of Diabetes in Experimental Animals: Cellular Basis for the Induction of Diabetes by Streptozotocin

1984 • 48 citations

CD86 (B70/B7–2) on endothelial cells co-stimulates allogeneic CD4⁺T cells

1995 • 45 citations

Primary porcine endothelial cells express membrane-bound B7-2 (CD86) and a soluble factor that co-stimulate cyclosporin A-resistant and CD28-dependent human T cell proliferation

1996 • 45 citations

Diabetogenic T-cell clones

1996 • 43 citations

B7/BB-1 expression and hepatitis activity in liver tissues of patients with chronic hepatitis C

1997 • 41 citations

CD28/B7 costimulation regulates autoimmune diabetes induced with multiple low doses of streptozotocin.

1997 • 37 citations

Autoimmune insulitis and diabetes in the absence of antigen-specific contact between T cells and β-islet cells

1999 • 30 citations

Genetic control of low-dose streptozotocin-induced autoimmune diabetes in mice.

1983 • 27 citations

Very-Low-Dose Streptozotocin Induces Diabetes in Insulin Promoter-mB7-1 Transgenic Mice

1995 • 27 citations

Transgenic mice expressing IFN-gamma in pancreatic beta-cells are resistant to streptozotocin-induced diabetes

1995 • 27 citations

The immune response to islets in experimental diabetes and insulin-dependent diabetes mellitus

1996 • 25 citations

Identification of an autologous insulin B chain peptide as a target antigen for H-2Kb-restricted cytotoxic T lymphocytes.

1992 • 23 citations

CD28 is not required for rejection of unmanipulated syngeneic and autologous tumors

1997 • 22 citations

Measurement of rat insulin. Enzyme-linked immunosorbent assay with increased sensitivity, high accuracy, and greater practicability than established radioimmunoassay

1988 • 22 citations

A CD8+ T-lymphocyte-mediated and CD4+ T-lymphocyte-independent autoimmune diabetes of early onset in transgenic mice

1994 • 19 citations

Immunologic studies on the induction of diabetes in experimental animals. Cellular basis for the induction of diabetes by streptozotocin

1984 • 18 citations

The generation of memory antigen‐specific cytotoxic T cell responses by CD28/CD80 interactions in the absence of antigen

1997 • 17 citations