Immunization with human papillomavirus type 16 (HPV16) oncoprotein-loaded dendritic cells as well as protein in adjuvant induces MHC class I-restricted protection to HPV16-induced tumor cells.

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1990 • 6,681 citations

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

1994 • 5,204 citations

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

Vaccination of patients with B–cell lymphoma using autologous antigen–pulsed dendritic cells

1996 • 1,854 citations

Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule.

1983 • 1,307 citations

Introduction of soluble protein into the class I pathway of antigen processing and presentation

1988 • 1,105 citations

Bone marrow-derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic antitumour immunity

1995 • 1,097 citations

Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4

1992 • 1,076 citations

Cloned dendritic cells can present exogenous antigens on both MHC class I and class II molecules.

1997 • 837 citations

IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt 2 antigen block T cell-mediated cytolysis in the absence of complement.

1980 • 835 citations

Vaccination with cytotoxic T lymphocyte epitope‐containing peptide protects against a tumor induced by human papillomavirus type 16‐transformed cells

1993 • 827 citations

Dendritic cells pulsed with protein antigens in vitro can prime antigen-specific, MHC-restricted T cells in situ.

1990 • 670 citations

Murine dendritic cells loaded in vitro with soluble protein prime cytotoxic T lymphocytes against tumor antigen in vivo.

1996 • 561 citations

Presentation of exogenous protein antigens by dendritic cells to T cell clones. Intact protein is presented best by immature, epidermal Langerhans cells.

1989 • 542 citations

A recombinant vaccinia virus encoding human papillomavirus types 16 and 18, E6 and E7 proteins as immunotherapy for cervical cancer

1996 • 538 citations

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1986 • 498 citations

Fluorescence-activated cell analysis and sorting of viable mammalian cells based on beta-D-galactosidase activity after transduction of Escherichia coli lacZ.

1988 • 487 citations

LacZ inducible, antigen/MHC-specific T cell hybrids

1994 • 377 citations

Presentation of Exogenous Antigen with Class I Major Histocompatibility Complex Molecules

1990 • 338 citations

Peptide vaccination can lead to enhanced tumor growth through specific T-cell tolerance induction.

1996 • 290 citations

Correlation of modified human papilloma virus early gene expression with altered growth properties in C4-1 cervical carcinoma cells.

1988 • 284 citations

MHC Class I–Restricted CTL Responses to Exogenous Antigens

1996 • 265 citations

Therapy of murine tumors with p53 wild-type and mutant sequence peptide-based vaccines.

1996 • 262 citations

Primary stimulation by dendritic cells induces antiviral proliferative and cytotoxic T cell responses in vitro.

1989 • 260 citations

Human papillomavirus type 16 nucleoprotein E7 is a tumor rejection antigen.

1991 • 249 citations

Direct activation of CD8+ cytotoxic T lymphocytes by dendritic cells.

1987 • 237 citations

Transfection and expression of a gene coding for a human melanoma antigen recognized by autologous cytolytic T lymphocytes

1992 • 198 citations

Cytotoxic T lymphocytes against a soluble protein

1987 • 178 citations

Immunization against human papillomavirus type 16 tumor cells with recombinant vaccinia viruses expressing E6 and E7

1991 • 160 citations

In vivo cytotoxic T lymphocyte induction with soluble proteins administered in liposomes.

1992 • 133 citations

Construction and characterisation of a recombinant vaccinia virus expressing human papillomavirus proteins for immunotherapy of cervical cancer

1996 • 123 citations

Induction of protective cytotoxic T cells with viral proteins

1994 • 91 citations

Ovalbumin injected with complete Freund's adjuvant stimulates cytolytic responses

1995 • 82 citations

Induction of antigen-specific class I-restricted cytotoxic T cells by soluble proteins in vivo.

1992 • 78 citations

Immunology of the human papilloma virus in relation to cancer

1994 • 77 citations

Induction of cytotoxic T lymphocytes with peptides in vitro: identification of candidate T-cell epitopes in human papilloma virus.

1992 • 75 citations

Development of malignancy following renal transplantation in Australia and New Zealand.

1992 • 65 citations

Priming of class I-restricted cytotoxic T lymphocytes by vaccination with recombinant protein antigens

1995 • 55 citations

Mechanisms of induction of primary virus‐specific cytotoxic T lymphocyte responses

1992 • 49 citations

Sensitization of MHC class I-restricted T cells to exogenous proteins: evidence for an alternative class I-restricted antigen presentation pathway.

1995 • 43 citations

The induction of cytotoxic T cells and tumor regression by soluble antigen formulation.

1995 • 42 citations

Processing and presentation of intact hen egg‐white lysozyme by dendritic cells

1992 • 42 citations

Immunization with soluble simian virus 40 large T antigen induces a specific response of CD3⁺ CD4⁻ CD8⁺ cytotoxic T lymphocytes in mice

1992 • 42 citations

Injection of detergent‐denatured ovalbumin primes murine class I‐restricted cytotoxic T cells in vivo

1994 • 41 citations

Presentation of an exogenous antigen by major histocompatibility complex class I molecules

1994 • 38 citations

Both Immunization with Protein and Recombinant Vaccinia Virus Can Stimulate CTL Specific for the E7 Protein of Human Papilloma Virus 16 in H‐2^d Mice

1995 • 36 citations

Priming in vivo and quantification in vitro of class I MHC-restricted cytotoxic T cells to human papilloma virus type 11 early proteins (E6 and E7) using immunostimulating complexes (ISCOMs)

1996 • 25 citations

Immunization with recombinant protein: conditions for cytotoxic T cell and/or antibody induction

1994 • 23 citations

Minireview

1994 • 17 citations

Processing of Exogenous Protein Antigen by Murine Dendritic Cells for Presentation to Cytotoxic T Lymphocytes

1997 • 1 citations