Presentation of an exogenous antigen by major histocompatibility complex class I molecules

Heterologous Protection Against Influenza by Injection of DNA Encoding a Viral Protein

1993 • 2,330 citations

Cytotoxic T-Cell Immunity to Influenza

1983 • 932 citations

Novel blockade by brefeldin A of intracellular transport of secretory proteins in cultured rat hepatocytes.

1986 • 847 citations

In vivo priming of virus-specific cytotoxic T lymphocytes with synthetic lipopeptide vaccine

1989 • 632 citations

Phagocytic processing of bacterial antigens for class I MHC presentation to T cells

1993 • 625 citations

Genes regulating HLA class I antigen expression in T-B lymphoblast hybrids

1985 • 580 citations

HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides

1992 • 502 citations

Induction of CD8+ cytotoxic T cells by immunization with purified HIV-1 envelope protein in ISCOMs

1990 • 479 citations

The biosynthetic pathway of MHC class II but not class I molecules intersects the endocytic route

1990 • 445 citations

The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds and internalizes Pseudomonas exotoxin A.

1992 • 444 citations

In vivo effector function of influenza virus-specific cytotoxic T lymphocyte clones is highly specific.

1984 • 439 citations

Class I-restricted processing and presentation of exogenous cell-associated antigen in vivo.

1990 • 414 citations

Presentation of Exogenous Antigen with Class I Major Histocompatibility Complex Molecules

1990 • 338 citations

A human homologue of the yeast HDEL receptor

1990 • 336 citations

Peptide binding to class I MHC on living cells and quantitation of complexes required for CTL lysis

1991 • 336 citations

Brefeldin A implicates egress from endoplasmic reticulum in class I restricted antigen presentation

1989 • 317 citations

Humoral and cell-mediated immune responses to live recombinant BCG–HIV vaccines

1991 • 315 citations

Pseudomonas exotoxin contains a specific sequence at the carboxyl terminus that is required for cytotoxicity.

1990 • 267 citations

Cycling of cell-surface MHC glycoproteins through primaquine-sensitive intracellular compartments

1990 • 254 citations

Processing of Pseudomonas exotoxin by a cellular protease results in the generation of a 37,000-Da toxin fragment that is translocated to the cytosol

1990 • 233 citations

Infectious Sindbis virus transient expression vectors for studying antigen processing and presentation.

1992 • 231 citations

Saponin adjuvant induction of ovalbumin-specific CD8+ cytotoxic T lymphocyte responses.

1992 • 224 citations

Cells Process Exogenous Proteins for Recognition by Cytotoxic T Lymphocytes

1988 • 217 citations

Endogenously synthesized peptide with an endoplasmic reticulum signal sequence sensitizes antigen processing mutant cells to class I-restricted cell-mediated lysis.

1991 • 215 citations

Increased cytotoxic activity of Pseudomonas exotoxin and two chimeric toxins ending in KDEL.

1991 • 213 citations

Mutations that impair a posttranscriptional step in expression of HLA-A and -B antigens.

1985 • 183 citations

Human T cell response to the surface antigen of hepatitis B virus (HBsAg). Endosomal and nonendosomal processing pathways are accessible to both endogenous and exogenous antigen.

1988 • 180 citations

Cytotoxic T lymphocytes against a soluble protein

1987 • 178 citations

Antigen Presentation Requires Transport of MHC Class I Molecules from the Endoplasmic Reticulum

1990 • 167 citations

Disruption of the Golgi apparatus by brefeldin A inhibits the cytotoxicity of ricin, modeccin, and Pseudomonas toxin

1991 • 156 citations

Purified Influenza Virus Nucleoprotein Protects Mice from Lethal Infection

1987 • 149 citations

Constitutive endocytosis of HLA class I antigens requires a specific portion of the intracytoplasmic tail that shares structural features with other endocytosed molecules.

1989 • 142 citations

The antibody-induced clustering and endocytosis of HLA antigens on cultured human fibroblasts

1980 • 137 citations

Intracellular transport of membrane glycoproteins: two closely related histocompatibility antigens differ in their rates of transit to the cell surface.

1985 • 127 citations

Spontaneous internalization of Class I major histocompatibility complex molecules in T lymphoid cells.

1984 • 120 citations

Processing of exogenous liposome-encapsulated antigens in vivo generates class I MHC-restricted T cell responses.

1992 • 117 citations

Induction of a cellular immune response to a foreign antigen by a recombinant Listeria monocytogenes vaccine.

1992 • 116 citations

Toxin entry: how reversible is the secretory pathway?

1992 • 107 citations

Biology of simian virus 40 (SV40) transplantation antigen (TrAg)

1980 • 99 citations

Antiviral Cytotoxic T Lymphocyte Induction and Vaccination

1988 • 98 citations

Internalization of lymphocyte membrane components

1985 • 94 citations

Major histocompatibility complex class I molecules internalized via coated pits in T lymphocytes

1987 • 82 citations

The morphology but not the function of endosomes and lysosomes is altered by brefeldin A.

1992 • 77 citations

Targeted delivery of peptide epitopes to class I major histocompatibility molecules by a modified Pseudomonas exotoxin.

1993 • 74 citations

Receptor-like nature of class I HLA: endocytosis via coated pits.

1988 • 71 citations

Effects of Brefeldin A on the Golgi complex, endoplasmic reticulum and viral envelope glycoproteins in murine erythroleukemia cells.

1991 • 71 citations

Brefeldin A inhibits the formation of constitutive secretory vesicles and immature secretory granules from the trans-Golgi network.

1992 • 68 citations

Endocytosis of the class I major histocompatibility antigen via a phorbol myristate acetate-inducible pathway is a cell-specific phenomenon and requires the cytoplasmic domain [published erratum appears in J Cell Biol 1989 Sep;109(3):1381]

1989 • 62 citations

Virus-induced loss of class I MHC antigens from the surface of cells infected with myxoma virus and malignant rabbit fibroma virus.

1992 • 61 citations

Endocytosis and dissociation of class I MHC molecules labeled with fluorescent beta-2 microglobulin.

1991 • 60 citations

Influenza virus hemagglutinin-specific cytotoxic T cell response induced by polypeptide produced in Escherichia coli.

1985 • 51 citations

Antigen processing mutant T2 cells present viral antigen restricted through H‐2K

1993 • 44 citations

Intracellular transport of class I histocompatibility molecules. Influence of protein folding on transport to the cell surface.

1988 • 42 citations

Kinetics of MHC gene expression and mRNA synthesis in brain endothelium.

1988 • 36 citations

Electroporation of exogenous antigen into the cytosol for antigen processing and class I major histocompatibility complex (MHC) presentation: weak base amines and hypothermia (18°C) inhibit the class I MHC processing pathway

1992 • 36 citations

Activation of protein kinase C accelerates internalization of transferrin receptor but not of major histocompatibility complex class I, independent of their phosphorylation status.

1992 • 34 citations

Influenza virus-specific cytotoxic T-cell recognition: stimulation of nucleoprotein-specific clones with intact antigen.

1986 • 22 citations

Soluble HLA-A2.1 restricted peptides that are recognized by influenza virus specific cytotoxic T lymphocytes

1991 • 20 citations

Functional activity in vivo of effector T cell populations III. Protection against Moloney murine sarcoma virus (M‐MSV)‐induced tumors in T cell deficient mice by the adoptive transfer of a M‐MSV‐specific cytolytic T lymphocyte clone

1987 • 13 citations

Direct analysis of peptide binding to cell-associated MHC class I molecules

1991 • 2 citations