Management of Acute Myeloid Leukemia in Elderly Patients

Acute Myeloid Leukemia in the Elderly: Assessment of Multidrug Resistance (MDR1) and Cytogenetics Distinguishes Biologic Subgroups With Remarkably Distinct Responses to Standard Chemotherapy. A Southwest Oncology Group Study

1997 • 897 citations

Cytosine arabinoside with daunorubicin or adriamycin for therapy of acute myelocytic leukemia: a CALGB study

1982 • 521 citations

A randomized placebo-controlled phase III study of granulocyte- macrophage colony-stimulating factor in adult patients (> 55 to 70 years of age) with acute myelogenous leukemia: a study of the Eastern Cooperative Oncology Group (E1490)

1995 • 462 citations

Granulocyte–Macrophage Colony-Stimulating Factor after Initial Chemotherapy for Elderly Patients with Primary Acute Myelogenous Leukemia

1995 • 458 citations

Effect of Granulocyte Colony-Stimulating Factor after Intensive Induction Therapy in Relapsed or Refractory Acute Leukemia

1990 • 403 citations

On the value of intensive remission-induction chemotherapy in elderly patients of 65+ years with acute myeloid leukemia: a randomized phase III study of the European Organization for Research and Treatment of Cancer Leukemia Group.

1989 • 395 citations

A phase III trial comparing idarubicin and daunorubicin in combination with cytarabine in acute myelogenous leukemia: a Southeastern Cancer Study Group Study.

1992 • 373 citations

Intensified induction and consolidation with or without maintenance chemotherapy for acute myeloid leukemia (AML): two multicenter studies of the German AML Cooperative Group.

1985 • 366 citations

A Randomized, Double-Blind, Placebo-Controlled, Phase III Study of Filgrastim in Remission Induction and Consolidation Therapy for Adults With De Novo Acute Myeloid Leukemia

1997 • 334 citations

PRINCIPAL RESULTS OF THE MEDICAL RESEARCH COUNCIL'S 8th ACUTE MYELOID LEUKAEMIA TRIAL

1986 • 329 citations

A Controlled Study of Recombinant Human Granulocyte Colony-Stimulating Factor in Elderly Patients after Treatment for Acute Myelogenous Leukemia

1995 • 321 citations

Clonal Development, Stem-Cell Differentiation, and Clinical Remissions in Acute Nonlymphocytic Leukemia

1987 • 319 citations

Comparison of three remission induction regimens and two postinduction strategies for the treatment of acute nonlymphocytic leukemia: a cancer and leukemia group B study

1987 • 305 citations

Prognostic impact of cytogenetic abnormalities in patients with de novo acute nonlymphocytic leukemia

1989 • 294 citations

Etoposide in acute nonlymphocytic leukemia. Australian Leukemia Study Group

1990 • 276 citations

Low-dose cytarabine versus intensive chemotherapy in the treatment of acute nonlymphocytic leukemia in the elderly.

1990 • 264 citations

Prognostic significance of karyotype in de novo adult acute myeloid leukemia. The BGMT group.

1995 • 254 citations

Use of recombinant granulocyte-macrophage colony-stimulating factor during and after remission induction chemotherapy in patients aged 61 years and older with acute myeloid leukemia (AML): final report of AML-11, a phase III randomized study of the Leukemia Cooperative Group of European Organisation for the research and treatment of cancer (EORTC-LCG) and the Dutch Belgian Hemato-Oncology Cooperative Group (HOVON)

1997 • 217 citations

Update of recommendations for the use of hematopoietic colony-stimulating factors: evidence-based clinical practice guidelines. American Society of Clinical Oncology.

1996 • 195 citations

A comparative study of two different doses of cytarabine for acute myeloid leukemia: a phase III trial of Cancer and Leukemia Group B

1991 • 177 citations

Recombinant human granulocyte-macrophage colony-stimulating factor after chemotherapy in patients with acute myeloid leukemia at higher age or after relapse

1991 • 165 citations

A Placebo-Controlled Study of Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor Administered During and After Induction Treatment for De Novo Acute Myelogenous Leukemia in Elderly Patients

1998 • 152 citations

Full dose versus attenuated dose daunorubicin, cytosine arabinoside, and 6-thioguanine in the treatment of acute nonlymphocytic leukemia in the elderly.

1984 • 149 citations

Long-term survival in acute myelogenous leukemia

1994 • 141 citations

AML associated with previous cytotoxic therapy, MDS or myeloproliferative disorders: results from the MRC's 9th AML trial

1989 • 139 citations

Acute myelogenous leukaemia in the elderly: retrospective study of 235 consecutive patients

1994 • 123 citations

Granulocyte Colony-Stimulating Factor (Filgrastim) Accelerates Granulocyte Recovery After Intensive Postremission Chemotherapy for Acute Myeloid Leukemia With Aziridinyl Benzoquinone and Mitoxantrone: Cancer and Leukemia Group B Study 9022

1997 • 113 citations

De novo acute myeloid leukaemia in patients over 55-years-old: a population-based study of incidence, treatment and outcome. Northern Region Haematology Group.

1995 • 113 citations

Dose intensification in acute myloid leukaemia: greater effectiveness at lower cost. Principal report of the Medical Research Council's ATML9 study

1996 • 109 citations

Intensive chemotherapy is the treatment of choice for elderly patients with acute myelogenous leukemia

1981 • 108 citations

Estimate of overall treatment results in acute nonlymphocytic leukemia based on age-specific rates of incidence and of complete remission.

1985 • 100 citations

Treatment of patients over 50 years of age with acute myelogenous leukemia with a combination of rubidazone and cytosine arabinoside, vincristine, and prednisone (ROAP)

1981 • 80 citations

De novo AML with dysplastic hematopoiesis: cytogenetic and prognostic significance.

1996 • 77 citations

Treatment of acute myeloid leukemia in elderly patients.A retrospective study

1988 • 66 citations

Use of cytokines in the treatment of acute myelocytic leukemia: a critical review.

1996 • 56 citations

Oral induction and consolidation of acute myeloid leukemia with etoposide, 6-thioguanine, and idarubicin (ETI) in elderly patients: a randomized comparison with 5-day TAD. Finnish Leukemia Group.

1994 • 54 citations

Hematopoietic growth factors in acute leukemia

1997 • 48 citations

The treatment of acute myeloid leukaemia preceded by the myelodysplastic syndrome

1992 • 42 citations

Cytosine arabinoside with daunorubicin or adriamycin for therapy of acute myelocytic leukemia: a CALGB study

1982 • 38 citations

Granulocyte colony-stimulating factor following chemotherapy in elderly patients with newly diagnosed acute myelogenous leukemia.

1996 • 27 citations

Relation between Age and Blast Cell Differentiation in Acute Myeloid Leukaemia Patients

1990 • 24 citations

Mitoxantrone and cytosine arabinoside as treatment for acute myeloblastic leukemia in older patients

1995 • 20 citations

Acute leukaemias

1992 • 19 citations

Acute nonlymphocytic leukemia in the elderly: results of a retrospective study.

1989 • 9 citations

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