The mechanism of 67Ga localization in malignant disease

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1987 • 1,360 citations

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Tumor scanning with 67Ga citrate.

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1964 • 240 citations

Regulation of the transferrin-independent iron transport system in cultured cells.

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1990 • 181 citations

Common Pathway for Tumor Cell Uptake of Gallium-67 and Iron-59 via a Transferrin Receptor

1980 • 142 citations

Iron metabolism-new perspectives in view

1992 • 140 citations

Inhibition of leukemic HL60 cell growth by transferrin-gallium: effects on ribonucleotide reductase and demonstration of drug synergy with hydroxyurea [see comments]

1988 • 140 citations

Tracer feasibility for monitoring tumor radiotherapy: a quadruple tracer study with fluorine-18-fluorodeoxyglucose or fluorine-18-fluorodeoxyuridine, L-[methyl-14C]methionine, [6-3H]thymidine, and gallium-67.

1991 • 138 citations

Gallium-67 Localization in Lysosomal-like Granules of Leukemic and Nonleukemic Murine Tissues<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1971 • 125 citations

Vascular-extravascular exchange of I¹³¹ plasma proteins in the rat

1959 • 123 citations

Uptake of gallium-67 by human leukemic cells: demonstration of transferrin receptor-dependent and transferrin-independent mechanisms.

1987 • 118 citations

Radiogallium localization in tumors: blood binding and transport and the role of transferrin.

1980 • 111 citations

The association of Ga-67 and lactoferrin.

1977 • 107 citations

Nuclear medicine : diagnosis and therapy

1996 • 106 citations

Lactoferrin binding sites and nuclear localization in K562(S) cells

1992 • 105 citations

Iron in Immunity: Cancer and Inflammation

1990 • 103 citations

Accessibility of circulating immunoglobulin G to the extravascular compartment of solid rat tumors.

1984 • 98 citations

Transferrin promotion of 67Ga and 59Fe uptake by cultured mouse myeloma cells.

1977 • 88 citations

67Ga binding to human serum proteins and tumor components.

1974 • 84 citations

The behaviour of tracer gallium-67 towards serum proteins

1972 • 84 citations

Gallium-67 Localization in Rat and Mouse Tumors

1970 • 83 citations

Iron-induced L1210 cell growth: evidence of a transferrin-independent iron transport.

1986 • 75 citations

Suggested models of ecotaxopathy in lymphoreticular malignancy. A role for iron-binding proteins in the control of lymphoid cell migration.

1978 • 75 citations

Isolation and characterization of a siderophore-like growth factor from mutants of SV40-transformed cells adapted to picolinic acid

1978 • 74 citations

Role of iron-binding proteins and enhanced capillary permeability on the accumulation of gallium-67.

1980 • 74 citations

Uptake of gallium-67 citrate and [2-3H]deoxyglucose in the tumor model, following chemotherapy and radiotherapy.

1985 • 73 citations

Effect of gallium on DNA synthesis by human T-cell lymphoblasts.

1988 • 65 citations

Hepatic recognition and catabolism of serum glycoproteins.

1981 • 65 citations

Metal ion speciation in blood plasma: gallium-67-citrate and MRI contrast agents.

1996 • 60 citations

Iron in immunity, cancer and inflammation

1989 • 60 citations

Studies of the in vivo entry of Ga-67 into normal and malignant tissue.

1981 • 53 citations

Brief Communication: Gallium-67 Citrate Uptake by Cultured Tumor Cells, Stimulated by Serum Transferrin234

1975 • 51 citations

Transferrin receptor expression in human hepatocellular carcinoma: an immunohistochemical study of 34 cases

1988 • 46 citations

Thermodynamics of gallium complexation by human lactoferrin

1986 • 44 citations

Ga-67 and Fe-59 distributions in mice.

1978 • 43 citations

Redox, transferrin-independent, and receptor-mediated endocytosis iron uptake systems in cultured human fibroblasts.

1993 • 42 citations

Decreased tumor uptake of gallium-67 in animals after whole-body irradiation.

1978 • 42 citations

Lactoferrin‐binding sites at the surface of HT29‐D4 cells

1989 • 41 citations

Distribution of gallium-67 in normal and hypotransferrinemic tumor-bearing mice.

1993 • 41 citations

A transferrin-mediated uptake of gallium-67 by EMT-6 sarcoma. II. Studies in vivo (BALB/c mice): concise communication.

1979 • 40 citations

The incorporation of Ga-67 into the ferritin fraction of rabbit hepatocytes in vivo.

1977 • 39 citations

Correlation of transferrin receptor expression with histologic grade and immunophenotype in chronic lymphocytic leukemia and non-Hodgkin's lymphoma.

1990 • 39 citations

Relationship between Gallium 67 Citrate Scanning and Transferrin Receptor Expression in Lung Diseases

1992 • 38 citations

The role of transferrin receptors in hemopoietic cell growth.

1990 • 38 citations

Binding of lactoferrin and transferrin to the human promonocytic cell line U937. Effect on iron uptake and release.

1993 • 37 citations

Uptake of lactoferrin by the liver. I. Role of the reticuloendothelial system as indicated by blockade experiments.

1984 • 36 citations

Studies of the vivo uptake of Ga-67 by an experimental abscess: concise communication.

1982 • 34 citations

Gallium-67/stable gadolinium antagonism: MRI contrast agent markedly alters the normal biodistribution of gallium-67.

1990 • 34 citations

Comparative pharmacokinetics of 67Ga and 59Fe in humans

1981 • 29 citations

The effects of inadvertent administration of antineoplastic agents prior to Ga-67 injection: concise communication.

1984 • 29 citations

A study of the macromolecular binding of 67Ga in normal and malignant animal tissues.

1973 • 29 citations

On the role of transferrin in the uptake of gallium by tumor cells

1979 • 28 citations

In vitro transfer of Ga-67 from transferrin to ferritin.

1983 • 28 citations

Factors affecting the binding of gallium-67 in serum

1980 • 28 citations

DNA polymerases of Walker 256 carcinosarcoma.

1974 • 27 citations

Modification of distribution of gallium 67 in man by administration of iron

1980 • 27 citations

Lactoferrin uptake and iron processing into macrophages: a study in familial haemochromatosis

1987 • 27 citations

Subcellular distribution of human asialotransferrin type 3 in the rat liver.

1981 • 27 citations

Inhibition of gallium-67 uptake in melanoma by an anti-human transferrin receptor monoclonal antibody.

1987 • 26 citations

67Ga and 59Fe uptakes by cultured human lymphoblasts and lymphocytes.

1978 • 26 citations

Pharmacologic Enhancement of Gallium-67 Tumor-to-Blood Ratios For EMT-6 Sarcoma (BALB/c Mice)

1979 • 25 citations

Transferrin receptor expression in benign tumours and in hepatoblastoma of the liver

1990 • 25 citations

The role of transferrin and other receptors in the mechanism of 67Ga localization

1990 • 25 citations

67Ga-transferrin and 67Ga-lactoferrin binding to tumor cells: Specific versus nonspecific glycoprotein-cell interaction

1983 • 24 citations

⁶⁷Ga Citrate Distribution Following Whole-Body Irradiation or Chemotherapy

1975 • 24 citations

Altered 67Ga citrate distribution in patients with multiple red blood cell transfusions

1982 • 23 citations

67Ga and 59Fe uptake in human melanoma cells

1979 • 23 citations

Localization of gallium in tumor cells. Electron microscopy, electron probe microanalysis and analytical ion microscopy

1983 • 23 citations

A quantitative study of the subcellular localization of 67Ga.

1976 • 23 citations

Serum inhibition of in vitro 67Ga binding by L1210 leukemic cells.

1975 • 21 citations

Frontiers in Nuclear Medicine

1980 • 21 citations

Demonstration of lactoferrin in tumor tissue from two patients with positive gallium scans.

1979 • 20 citations

Accumulation and localization of gallium-67 in various types of primary lung carcinoma.

1978 • 20 citations

Effect of desferoxamine on tissue and tumor retention of gallium-67: concise communication.

1979 • 19 citations

CD71 phenotype and the value of gallium imaging in lymphomas

1991 • 19 citations

Alteration of gallium-67 distribution in tumor-bearing mice following treatment with methotrexate: concise communication.

1981 • 18 citations

Exchange of iron and transferrin across endothelial surfaces in the rat and rabbit

1963 • 18 citations

Effects of Desferrioxamine on 67Ga Distributions in Tumor-Bearing Mice

1979 • 17 citations

Radiopharmaceuticals II: proceedings of the 2nd international symposium on radiopharmaceuticals

1980 • 16 citations

Role of phosphate-containing compounds in the transfer of indium-111 and gallium-67 from transferrin to ferritin.

1989 • 16 citations

Nuclear medicine: diagnosis and therapy

1996 • 15 citations

Compounds which mediate gallium-67 transfer from lactoferrin to ferritin.

1985 • 15 citations

Relationships between the metabolism of 67Ga and iron

1981 • 12 citations

Mechanisms of distribution of gallium 67 in mouse tumour hosts

1982 • 12 citations

Hepatic recognition and catabolism of serum glycoproteins

1981 • 12 citations

The relationships between the Ga-67 uptake and nuclear DNA Feulgen content in thyroid tumors: concise communication.

1982 • 11 citations

Assays for transferrin and transferrin receptors in tumour and other mouse tissues

1981 • 10 citations

Rapid excretion of gallium‐67 isotope in an iron‐overloaded patient receiving high‐dose intravenous deferoxamine

1988 • 10 citations

The relative stabilities of 67Ga complexes lactoferrin and transferrin at various pH's

1981 • 10 citations

A preliminary investigation of 67Ga citrate distribution in hyperferraemic patients

1980 • 9 citations

Gallium-67 distribution in a man with a decrease in both transferrin and hepatic gallium-67 concentration.

1992 • 9 citations

The relationship between Ga-67 accumulation and cell cycle in malignant tumor cells in vitro

1988 • 8 citations

Gallium-67 uptake by hepatoma: studies in cell cultures, perfused livers, and intact rats.

1985 • 7 citations

The relationship between 67Ga accumulation and ATP metabolism in tumor cells in vitro

1989 • 6 citations

The source of gallium-67 in gastrointestinal contents: concise communication.

1980 • 5 citations

Enhancement of hepatic gallium-67 uptake by asialo-transferrin.

1986 • 5 citations

67Ga imaging incorporating administration of iron

1981 • 5 citations

Altered biodistribution of gallium-67 in a patient with aluminum toxicity treated with desferoxamine.

1990 • 4 citations

On the mechanism of gallium accumulation in tumours. Isolation of N-hydroxypeptides

1986 • 3 citations

Altered Biodistribution of Ga-67 Citrate in an Iron-Overloaded Patient With Sickle Cell Disease

1994 • 3 citations

Factors Affecting 67Ga Distribution

1980 • 2 citations

Effects of iron-binding proteins on in vitro uptake of 67Ga-citrate by tumor cells

1990 • 1 citations

Desferal (DFO) induced 67Ga washout from normal tissue, tumor and abscess in experimental animals

1983 • 1 citations