Iron chelators as therapeutic agents for the treatment of cancer

Cloning and characterization of a mammalian proton-coupled metal-ion transporter

1997 • 3,130 citations

The ferritins: molecular properties, iron storage function and cellular regulation

1996 • 2,572 citations

Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress.

1996 • 1,311 citations

Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene

1997 • 1,178 citations

Reduction of Ribonucleotides

1979 • 1,170 citations

Iron-Chelating Therapy and the Treatment of Thalassemia

1997 • 1,106 citations

Iron withholding: a defense against infection and neoplasia.

1984 • 893 citations

Stabilization of wild-type p53 by hypoxia-inducible factor 1α

1998 • 818 citations

The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells

1997 • 697 citations

Enzymology of Cancer Cells

1977 • 641 citations

Molecular Cloning of Transferrin Receptor 2

1999 • 638 citations

Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status.

1994 • 620 citations

The Biochemistry of Desferrioxamine and its Relation to Iron Metabolism

1964 • 620 citations

Binding of apotransferrin to K562 cells: explanation of the transferrin cycle.

1983 • 603 citations

Function and regulation of transferrin and ferritin.

1998 • 518 citations

Low molecular weight intracellular iron transport compounds

1977 • 389 citations

Modulation of cell surface iron transferrin receptors by cellular density and state of activation

1979 • 366 citations

Two New p73 Splice Variants, γ and δ, with Different Transcriptional Activity

1998 • 363 citations

Identification of a Hypoxia Response Element in the Transferrin Receptor Gene

1999 • 359 citations

Transferrin Receptor Induction by Hypoxia

1999 • 352 citations

Triapine (3-aminopyridine-2-carboxaldehyde- thiosemicarbazone): A potent inhibitor of ribonucleotide reductase activity with broad spectrum antitumor activity

2000 • 350 citations

The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents

1995 • 343 citations

Monoclonal antibody to transferrin receptor blocks transferrin binding and inhibits human tumor cell growth in vitro.

1982 • 335 citations

Coordinated Regulation of Iron-Controlling Genes, H-Ferritin and IRP2 , by c-MYC

1999 • 319 citations

Transferrin, biochemistry, physiology and clinical significance

1981 • 310 citations

Ribonucleotide Reductase and Cell Proliferation

1970 • 307 citations

Sequential expression of genes involved in human T lymphocyte growth and differentiation.

1985 • 291 citations

Iron Regulates the Intracellular Degradation of Iron Regulatory Protein 2 by the Proteasome

1995 • 285 citations

Interleukin 2 (IL-2) augments transcription of the IL-2 receptor gene.

1985 • 280 citations

Iron-dependent changes in cellular energy metabolism: influence on citric acid cycle and oxidative phosphorylation

1999 • 277 citations

Transferrin receptor 2: Continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis

2000 • 276 citations

Cytoplasmic Sequestration of Wild-Type p53 Protein Impairs the G₁ Checkpoint after DNA Damage

1996 • 274 citations

Control of cell proliferation by Myc

1998 • 251 citations

Cancer Chemotherapeutic Agents

2000 • 237 citations

Transferrin Receptor 2-α Supports Cell Growth Both in Iron-chelated Cultured Cells and in Vivo

2000 • 235 citations

Molecular characterization of a second iron-responsive element binding protein, iron regulatory protein 2. Structure, function, and post-translational regulation.

1994 • 221 citations

Clinical Pediatric Oncology

1974 • 220 citations

The Potential of Iron Chelators of the Pyridoxal Isonicotinoyl Hydrazone Class as Effective Antiproliferative Agents II: The Mechanism of Action of Ligands Derived From Salicylaldehyde Benzoyl Hydrazone and 2-Hydroxy-1-Naphthylaldehyde Benzoyl Hydrazone

1997 • 205 citations

Effects of a single course of deferoxamine in neuroblastoma patients.

1990 • 197 citations

Mobilization of iron from reticulocytes

1979 • 196 citations

Copper chaperones: function, structure and copper-binding properties

1999 • 195 citations

A study of intracellular iron metabolism using pyridoxal isonicotinoyl hydrazone and other synthetic chelating agents

1979 • 192 citations

Review of Medical Pharmacology.

1969 • 190 citations

Continual presence of oxygen and iron required for mammalian ribonucleotide reduction: Possible regulation mechanism

1983 • 190 citations

Cytotoxic chelators and chelates 1. Inhibition of DNA synthesis in cultured rodent and human cells by aroylhydrazones and by a copper(II) complex of salicylaldehyde benzoyl hydrazone

1982 • 188 citations

In vitro and in vivo effects of deferoxamine in neonatal acute leukemia

1987 • 185 citations

HIF-1-mediated activation of transferrin receptor gene transcription by iron chelation

1999 • 184 citations

The uptake of iron and transferrin by the human malignant melanoma cell

1990 • 178 citations

The Potential of Iron Chelators of the Pyridoxal Isonicotinoyl Hydrazone Class as Effective Antiproliferative Agents III: The Effect of the Ligands on Molecular Targets Involved in Proliferation

1999 • 163 citations

Synthesis and antitumor activity of amino derivatives of pyridine-2-carboxaldehyde thiose micarbazone

1992 • 158 citations

Promoter specificity and stability control of the p53-related protein p73

1999 • 149 citations

Antineuroblastoma activity of desferoxamine in human cell lines.

1987 • 146 citations

Crystal and molecular structure of 2-hydroxy-1-naphthaldehyde isonicotinoyl hydrazone (NIH) and its iron(III) complex: an iron chelator with anti-tumour activity

1999 • 143 citations

Common Pathway for Tumor Cell Uptake of Gallium-67 and Iron-59 via a Transferrin Receptor

1980 • 142 citations

The effect of the iron(III) chelator, desferrioxamine, on iron and transferrin uptake by the human malignant melanoma cell.

1994 • 141 citations

Effects of different transferrin forms on transferrin receptor expression, iron uptake, and cellular proliferation of human leukemic HL60 cells. Mechanisms responsible for the specific cytotoxicity of transferrin-gallium.

1986 • 138 citations

Distribution of iron in reticulocytes after inhibition of heme synthesis with succinylacetone: examination of the intermediates involved in iron metabolism

1996 • 137 citations

Role of ribonucleotide reductase in expression of the neoplastic program

1981 • 136 citations

Mechanism of inhibition of mammalian ribonucleotide reductase by the iron chelate of 1-formylisoquinoline thiosemicarbazone. Destruction of the tyrosine free radical of the enzyme in an oxygen-requiring reaction.

1983 • 131 citations

Evaluation of the iron chelation potential of hydrazones of pyridoxal, salicylaldehyde and 2-hydroxy-1-naphthylaldehyde using the hepatocyte in culture

1992 • 130 citations

Regulation and function of the p53-related proteins: same family, different rules

2000 • 123 citations

Two mechanisms of iron uptake from transferrin by melanoma cells. The effect of desferrioxamine and ferric ammonium citrate.

1992 • 121 citations

Uptake of gallium-67 by human leukemic cells: demonstration of transferrin receptor-dependent and transferrin-independent mechanisms.

1987 • 118 citations

Structure, function and regulation of p63 and p73

1999 • 118 citations

Expression of p53 in human neuroblastoma- and neuroepithelioma-derived cell lines.

1992 • 117 citations

Clinical and pharmacological studies with 5-hydroxy-2-formylpyridine thiosemicarbazone.

1972 • 113 citations

Pharmacokinetics and Pharmacodynamics of Hydroxyurea

1998 • 109 citations

Deferoxamine inhibition of human neuroblastoma viability and proliferation.

1988 • 108 citations

Inhibitors of ribonucleotide reductase

1994 • 106 citations

The carcinostatic activity of alpha-(N) heterocyclic carboxaldehyde thiosemicarbazones. I. Isoquinoline-1-carboxaldehyde thiosemicarbazone.

1965 • 99 citations

Tumor Cell Cytotoxicity of a Novel Metal Chelator

1998 • 99 citations

7 The Chemistry and Biological Activity of α -(N)-Heterocyclic Carboxaldehyde Thiosemicarbazones

1978 • 98 citations

Antitumor effect of deferoxamine on human hepatocellular carcinoma growing in athymic nude mice

1992 • 97 citations

Studies of the reaction of 2-formylpyridine thiosemicarbazone and its iron and copper complexes with biological systems.

1977 • 94 citations

Effective Iron Chelation following Oral Administration of an Isoniazid‐Pyridoxal Hydrazone

1979 • 94 citations

Inhibition of ribonucleotide reductase by gallium in murine leukemic L1210 cells.

1991 • 94 citations

Transferrin receptor-independent uptake of differic transferrin by human hepatoma cells with antisense inhibition of receptor expression

1996 • 93 citations

Inhibition of the growth of cultured cells and an implanted fibrosarcoma by aroylhydrazone analogs of the Gly-His-Lys-Cu (II) complex

1983 • 91 citations

Mechanism of inhibition of ribonucleoside diphosphate reductase by ga-(n)-heterocyclic aldehyde thiosemicarbazones

1971 • 88 citations

Transferrin promotion of 67Ga and 59Fe uptake by cultured mouse myeloma cells.

1977 • 88 citations

Iron chelators of the pyridoxal isonicotinoyl hydrazone class Part II. Formation constants with iron(III) and iron(II)

1990 • 87 citations

Two saturable mechanisms of iron uptake from transferrin in human melanoma cells: The effect of transferrin concentration, chelators, and metabolic probes on transferrin and iron uptake

1994 • 86 citations

Transferrin receptor-independent uptake of differic transferrin by human hepatoma cells with antisense inhibition of receptor expression

1996 • 84 citations

The effect of intracellular iron concentration and nitrogen monoxide on Nramp2 expression and non‐transferrin‐bound iron uptake

1999 • 84 citations

Biliary Iron Excretion in Rats following Pyridoxal Isonicotinoyl Hydrazone

1980 • 81 citations

Development of novel aroylhydrazone ligands for iron chelation therapy: 2-Pyridylcarboxaldehyde isonicotinoyl hydrazone analogs

1999 • 79 citations

Up-regulation of hypoxia-inducible factor-1alpha is not sufficient for hypoxic/anoxic p53 induction.

1998 • 79 citations

Effect of dietary iron deficiency or excess on the induction of mammary carcinogenesis by 1-methyl-1-nitrosourea

1991 • 79 citations

The inhibition of ribonucleoside diphosphate reductase by hydroxyurea, guanazole and pyrazoloimidazole (IMPY)

1985 • 75 citations

Antiproliferative and apoptotic effects of O-Trensox, a new synthetic iron chelator, on differentiated human hepatoma cell lines

2000 • 71 citations

Deferoxamine followed by cyclophosphamide, etoposide, carboplatin, thiotepa, induction regimen in advanced neuroblastoma: Preliminary results

1995 • 70 citations

Deferoxamine in children with recurrent neuroblastoma.

1994 • 70 citations

Iron chelation by pyridoxal isonicotinoyl hydrazone and analogues in hepatocytes in culture

1985 • 68 citations

Iron chelators of the pyridoxal isonicotinoyl hydrazone class

1989 • 65 citations

Deferoxamine, Cyclophosphamide, Etoposide, Carboplatin, and Thiotepa (D-CECaT)

1992 • 64 citations

Inhibitors of Ribonucleoside Diphosphate Reductase Activity

1989 • 60 citations

The mechanisms of iron uptake by fetal rat hepatocytes in culture

1986 • 59 citations

Role of Deferoxamine in Tumor Therapy

1996 • 59 citations

Potential of iron chelators as effective antiproliferative agents

1997 • 58 citations

p53 in chronic myeloid leukemia cell lines.

1992 • 56 citations

Neuroblastomas contain iron-rich ferritin

1988 • 55 citations

Failure of iron chelators to reduce tumor growth in human neuroblastoma xenografts.

1998 • 52 citations

Nicotinyl and Isonicotinyl Hydrazones of Pyridoxal

1954 • 52 citations

Hydroxyurea (NSC-32065) in biologic fluids: dose-concentration relationship.

1965 • 51 citations

Effect of iron-chelating agents on inhibitors of ribonucleotide reductase

1981 • 49 citations

Inhibition of the growth of sarcoma 180 ascites cells by combinations of inhibitors of nucleic acid biosynthesis and the cupric chelate of kethoxal bis-(thiosemicarbazone).

1967 • 48 citations

Studies of the antineoplastic activity and metabolism of -(N)-heterocyclic carboxaldehyde thiosemicarbazones in dogs and mice.

1972 • 47 citations

Resistance to the Antitumor Agent Gallium Nitrate in Human Leukemic Cells Is Associated with Decreased Gallium/Iron Uptake, Increased Activity of Iron Regulatory Protein-1, and Decreased Ferritin Production

1997 • 47 citations

Potential of iron chelators as effective antiproliferative agents

1997 • 45 citations

Effects of agents that inhibit cellular iron incorporation on bladder cancer cell proliferation

1993 • 43 citations

Effects of desferrioxamine on normal and leukemic human hematopoietic cell growth: in vitro and in vivo studies.

1989 • 43 citations

Inhibition of lymphoma growth in vivo by combined treatment with hydroxyethyl starch deferoxamine conjugate and IgG monoclonal antibodies against the transferrin receptor.

1995 • 42 citations

Inhibition of hematopoietic tumor growth by combined treatment with deferoxamine and an IgG monoclonal antibody against the transferrin receptor: evidence for a threshold model of iron deprivation toxicity.

1992 • 39 citations

Inhibitory effect of deferoxamine mesylate and low iron diet on the 13762NF rat mammary adenocarcinoma.

1999 • 38 citations

Demonstration of nitrogen coordination in metal-bleomycin complexes by electron spin-echo envelope spectroscopy

1981 • 36 citations

Clinical trial of 5-hydroxypicolinaldehyde thiosemicarbazone (5-HP; NSC-107392), with special reference to its iron-chelating properties.

1974 • 34 citations

Review of Medical Pharmacology

1981 • 33 citations

Synergistic Interaction of Kethoxal bis(Thiosemicarbazone) and Cupric Ions in Sarcoma 180

1966 • 33 citations

Transferrin and iron distribution in subcellular fractions of K562 cells in the early stages of transferrin endocytosis

1992 • 32 citations

Structure-function relationships for a new series of pyridine-2-carboxaldehyde thiosemicarbazones on ribonucleotide reductase activity and tumor cell growth in culture and in vivo

1995 • 32 citations

Metabolic Effects of Copper in Intact Cells: Comparative Activity of Cupric Chloride and the Cupric Chelate of Kethoxal Bis(thiosemicarbazone)

1967 • 29 citations

Synergistic inhibition of lymphoid tumor growth in vitro by combined treatment with the iron chelator deferoxamine and an immunoglobulin G monoclonal antibody against the transferrin receptor

1990 • 29 citations

Involvement of the tumor suppressor gene p53 in tumor necrosis factor-induced differentiation of the leukemic cell line K562.

1995 • 27 citations

Orally effective iron chelators for the treatment of iron overload disease: The case for a further look at pyridoxal isonicotinoyl hydrazone and its analogs

1998 • 26 citations

Inhibition of gallium-67 uptake in melanoma by an anti-human transferrin receptor monoclonal antibody.

1987 • 26 citations

Chelating Substances

2015 • 25 citations

The Synthesis, Crystal and Molecular Structure, and Oxidation State of Iron Complex from Pyridoxal Isonicotinoyl Hydrazone and Ferrous Sulphate

1985 • 24 citations

Iron deprivation and cancer: a view beginning with studies of monoclonal antibodies against the transferrin receptor.

1997 • 24 citations

Regulation of ribonucleotide reductase activity and its possible exploitation in chemotherapy

1979 • 23 citations

Metabolic effects of zinc in intact cells—Comparative studies of zinc chloride and the zinc chelate of kethoxal bis(thiosemicarbazone)

1971 • 20 citations

Studies on the mode of action of the copper(II)chelate of 2-keto-3-ethoxybutyraldehyde-bis(thiosemicarbazone).

1968 • 18 citations

Complexes of gallium(III) and other metal ions and their potential in the treatment of neoplasia

2000 • 18 citations

Evaluation of transferrin and gallium-pyridoxal isonicotinoyl hydrazone as potential therapeutic agents to overcome lymphoid leukemic cell resistance to gallium nitrate.

1996 • 17 citations

Effect of iron chelators with potent anti-proliferative activity on the expression of molecules involved in cell cycle progression and growth

1999 • 16 citations

Pyridoxal Isonicotinoyl Hydrazone (PIH), a Synthetic Ion-Chelating Agent

1995 • 10 citations

Iron Chelation in Cancer Therapy

1999 • 3 citations