Human suppressor T cells: Induction, differentiation, and regulatory functions

The differentiation and function of human T lymphocytes

1980 • 1,548 citations

Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule.

1983 • 1,307 citations

Antigen-Presenting Function of the Macrophage

1984 • 1,164 citations

Evolutionary conservation of surface molecules that distinguish T lymphocyte helper/inducer and cytotoxic/suppressor subpopulations in mouse and man

1981 • 871 citations

The isolation and characterization of the human suppressor inducer T cell subset.

1985 • 860 citations

The isolation and characterization of the human helper inducer T cell subset.

1985 • 708 citations

T Cell Subsets and the Recognition of MHC Class

1983 • 702 citations

Clonal analysis of human cytotoxic T lymphocytes: T4+ and T8+ effector T cells recognize products of different major histocompatibility complex regions.

1982 • 600 citations

Growth of a cloned helper T cell line induced by a monoclonal antibody specific for the antigen receptor: interleukin 1 is required for the expression of receptors for interleukin 2.

1984 • 529 citations

A molecular map of the immune response region from the major histocompatibility complex of the mouse

1982 • 466 citations

Activation of human T lymphocyte subsets: helper and suppressor/cytotoxic T cells recognize and respond to distinct histocompatibility antigens.

1981 • 338 citations

Cyclophosphamide-sensitive T lymphocytes suppress the in vivo generation of antigen-specific cytotoxic T lymphocytes

1977 • 337 citations

Monoclonal antibodies identifying a novel T-Cell antigen and Ia antigens of human lymphocytes

1980 • 326 citations

Possible involvement of the OKT4 molecule in T cell recognition of class II HLA antigens. Evidence from studies of cytotoxic T lymphocytes specific for SB antigens.

1982 • 306 citations

Human T cell activation. II. A new activation pathway used by a major T cell population via a disulfide-bonded dimer of a 44 kilodalton polypeptide (9.3 antigen).

1985 • 285 citations

The Generative Grammar of the Immune System

1985 • 284 citations

A Single Major Pathway of T‐Lymphocyte Interactions in Antigen‐Specific Immune Suppression

1981 • 281 citations

Coexpression of T4 and T8 on peripheral blood T cells demonstrated by two-color fluorescence flow cytometry.

1985 • 261 citations

Characterization of a phenotypically distinct subpopulation of Leu-2+ cells that suppresses T cell proliferative responses.

1983 • 251 citations

Dissection of immunoregulatory subpopulations of T lymphocytes within the helper and suppressor sublineages in man.

1982 • 246 citations

Effect of cyclosporin A on human lymphocyte responses in vitro. I. CsA allows for the expression of alloantigen-activated suppressor cells while preferentially inhibiting the induction of cytolytic effector lymphocytes in MLR.

1980 • 239 citations

Long-term human cytolytic T-cell lines allospecific for HLA-DR6 antigen are OKT4+.

1982 • 237 citations

Biological expressions of lymphocyte activation. 3. Suppression of plaque-forming cell responses in vitro by supernatant fluids from concanavalin A-activated spleen cell cultures.

1974 • 235 citations

Immune Response(Ir)Genes of the Murine Major Histocompatibility Complex

1986 • 217 citations

Morphologic and phenotypic features of the subpopulation of Leu-2+ cells that suppresses B cell differentiation.

1984 • 196 citations

Functional characterization of human T lymphocyte subsets distinguished by monoclonal anti-leu-8.

1985 • 180 citations

Role of prostaglandin E2 in the induction of nonspecific T lymphocyte suppressor activity.

1981 • 179 citations

Functional analysis of human T cell subsets defined by monoclonal antibodies. V. Suppressor cells within the activated OKT4+ population belong to a distinct subset.

1982 • 162 citations

Genetics of the Major Histocompatibility Complex: The Final Act

1983 • 146 citations

Involvement of T44 molecules in an antigen-independent pathway of T cell activation. Analysis of the correlations to the T cell antigen-receptor complex.

1985 • 142 citations

T cell growth factor abrogates concanavalin A-induced suppressor cell function

1981 • 137 citations

Biological Expressions of Lymphocyte Activation

1974 • 124 citations

Soluble antigen-primed inducer T cells activate antigen-specific suppressor T cells in the absence of antigen-pulsed accessory cells: phenotypic definition of suppressor-inducer and suppressor-effector cells.

1984 • 121 citations

A human suppressor T cell clone which recognizes an autologous helper T cell clone

1982 • 119 citations

Soluble suppressor supernatants elaborated by concanavalin A-activated human mononuclear cells. I. Characterization of a soluble suppressor T cell proliferation.

1981 • 107 citations

Regulation of immune responses by suppressor T cells.

1976 • 91 citations

Suppression of T cell responses through competition for T cell growth factor (interleukin 2)

1982 • 83 citations

The clusters of differentiation (CD) defined by the First International Workshop on human leucocyte differentiation antigens

1984 • 79 citations

Generation of Cytotoxic T Lymphocytes in Vitro VII. Suppressive Effect of Irradiated MLC Cells on CTL Response

1976 • 79 citations

Monoclonal antibody 9.3 and anti‐CD11 antibodies define reciprocal subsets of lymphocytes

1985 • 78 citations

Partial characterization of a prostaglandin-induced suppressor factor

1980 • 76 citations

Immunoregulatory T cell circuits in man. Alloantigen-primed inducer T cells activate alloantigen-specific suppressor T cells in the absence of the initial antigenic stimulus.

1983 • 72 citations

Control of polyclonal immunoglobulin production from human lymphocytes by leukotrienes; leukotriene B4 induces an OKT8(+), radiosensitive suppressor cell from resting, human OKT8(-) T cells.

1984 • 72 citations

Identification of the lymphokine soluble immune response suppressor in urine of nephrotic children.

1985 • 69 citations

Relationship between Human T Cell Functional Heterogeneity and Human T Cell Surface Molecules

1983 • 68 citations

Human T lymphocyte subsets. Functional heterogeneity and surface recognition structures.

1984 • 67 citations

Soluble suppressor supernatants elaborated by concanavalin A-activated human mononuclear cells. II. Characterization of a soluble suppressor of B cell immunoglobulin production.

1981 • 67 citations

Prostaglandins and Immunity

1985 • 66 citations

Identification and initial characterization of concanavalin A- and interferon-induced human suppressor factors: evidence for a human equivalent of murine soluble immune response suppressor (SIRS).

1984 • 62 citations

An autoreactive T cell clone that can be activated to provide both helper and suppressor function.

1986 • 58 citations

Acquisition of suppressive activity and natural killer-like cytotoxicity by human alloproliferative "helper" T cell clones.

1986 • 54 citations

Regulatory mechanisms in cytotoxic T lymphocyte development. I. A suppressor T cell subset that regulates the proliferative stage of CTL development.

1983 • 49 citations

Activation of antigen-specific suppressor T cells in the presence of cyclosporin requires interactions between T cells of inducer and suppressor lineage.

1983 • 48 citations

A cloned T-cell line from a tolerant mouse represents a novel antigen-specific suppressor cell type

1982 • 48 citations

Generation of Cytotoxic T Lymphocytes in Vitro

1976 • 45 citations

Prostaglandins and immunity

1984 • 43 citations

Role of interleukin 1 in antigen-specific T cell proliferation.

1984 • 43 citations

Immunoregulatory T cell circuits in man. Identification of a distinct T cell subpopulation of the helper/inducer lineage that amplifies the development of alloantigen-specific suppressor T cells.

1985 • 42 citations

Purification and characterization of a monoclonal T-cell suppressor factor specific for poly(LGlu60LAla30LTyr10).

1982 • 42 citations

Conversion of soluble immune response suppressor to macrophage-derived suppressor factor by peroxide.

1981 • 40 citations

Regulatory interactions governing the proliferation of T cell subsets stimulated with pokeweed mitogen.

1984 • 39 citations

A human alloreactive inducer T cell clone that selectively activates antigen-specific suppressor T cells.

1984 • 31 citations

I‐J as a Restriction Element in the Suppressor T Cell System

1985 • 30 citations

Functional analysis of human T cell subsets defined by monoclonal antibodies. VI. Distinct and opposing immunoregulatory functions within the OKT8+ population.

1984 • 23 citations

Opposing immunoregulatory functions of CD8+ lymphocytes: a requirement for monocytes in suppressor cell induction.

1986 • 22 citations

DIAGNOSTIC AND THERAPEUTIC IMPLICATIONS OF T CELL SURFACE ANTIGENS

1985 • 22 citations

Proliferative signals for suppressor T cells. Helper cells stimulated with pokeweed mitogen in vitro produce a suppressor cell growth factor.

1986 • 21 citations

Chemical features of an antigen-specific suppressor T cell factor composed of two polypeptide chains.

1984 • 19 citations

A human T cell-derived soluble factor able to suppress pokeweed mitogen-induced immunoglobulin production.

1983 • 18 citations

Alloreactive T cells: Expression of HLA-D antigens, stimulation of autologous MLR, and possible immunoregulatory function

1981 • 16 citations

Regulation of immunoglobulin synthesis by human T cell subsets as defined by anti-D44 monoclonal antibody within the CD4+ and CD8+ subpopulations.

1986 • 15 citations

Immunoregulatory activity of T-cell subsets activated in human mixed lymphocyte reaction

1983 • 14 citations

Soluble suppressor factor produced by pokeweed mitogen-stimulated human peripheral blood leukocytes

1980 • 13 citations

The phenotype of antigen-specific suppressor T cells generated in human mixed leucocyte culture depends on the nature of the major histocompatibility regions recognized

1984 • 10 citations

Specific loss of stimulator activity following mixed lymphocyte reactions is due to cytotoxic cells

1976 • 6 citations

T-T cell interactions in cell-mediated immune responses to major histocompatibility complex antigens.

1983 • 4 citations