?Seed and soil? revisited: mechanisms of site-specific metastasis

THE DISTRIBUTION OF SECONDARY GROWTHS IN CANCER OF THE BREAST.

1889 • 4,920 citations

The pathogenesis of cancer metastasis

1980 • 1,750 citations

Metastasis Results from Preexisting Variant Cells Within a Malignant Tumor

1977 • 1,422 citations

Role of collagenous matrices in the adhesion and growth of cells.

1981 • 1,375 citations

Selection of Successive Tumour Lines for Metastasis

1973 • 1,360 citations

Distribution of cervical lymph node metastases from squamous cell carcinoma of the upper respiratory and digestive tracts

1972 • 997 citations

Transforming growth factors produced by certain human tumor cells: polypeptides that interact with epidermal growth factor receptors.

1980 • 892 citations

The Biology of Cancer Invasion and Metastasis

1978 • 819 citations

Long-term culture of capillary endothelial cells.

1979 • 780 citations

Role of laminin in the attachment of PAM 212 (epithelial) cells to basement membrane collagen

1980 • 661 citations

Tumor Angiogenesis

1974 • 470 citations

Proceedings: Tumor angiogenesis factor.

1974 • 469 citations

Accurate Identification of Experimental Pulmonary Metastases2

1966 • 418 citations

Role of organ selectivity in the determination of metastatic patterns of B16 melanoma.

1980 • 417 citations

Fundamental Aspects of Metastasis

1977 • 412 citations

In vitro selection of murine B16 melanoma variants with enhanced tissue-invasive properties.

1980 • 408 citations

Factors involved in the modulation of cell proliferation in vivo and in vitro: The role of fibroblast and epidermal growth factors in the proliferative response of mammalian cells

1978 • 360 citations

Organ Selectivity for Implantation Survival and Growth of B16 Melanoma Variant Tumor Lines 2

1976 • 297 citations

Basement membrane changes in breast cancer detected by immunohistochemical staining for laminin.

1981 • 271 citations

Interactions of tumor cells with vascular endothelial cell monolayers: a model for metastatic invasion.

1979 • 270 citations

Arrest and metastasis of blood-borne tumor cells are modified by fusion of plasma membrane vesicles from highly metastatic cells.

1980 • 261 citations

Metastatic heterogeneity of cells from an ultraviolet light-induced murine fibrosarcoma of recent origin.

1978 • 248 citations

Respective roles of laminin and fibronectin in adhesion of human carcinoma and sarcoma cells

1981 • 218 citations

Metastatic tumor cells adhere preferentially to the extracellular matrix underlying vascular endothelial cells

1980 • 212 citations

Organ specificity of blood-borne tumour metastasis determined by cell adhesion?

1975 • 207 citations

Biological markers of neoplasia: Basic and applied aspects

1979 • 206 citations

Specificity of arrest, survival, and growth of selected metastatic variant cell lines.

1978 • 203 citations

A general method for the introduction of enzymes, by means of immunoglobulin-coated liposomes, into lysosomes of deficient cells.

1975 • 195 citations

The implications of tumor heterogeneity for studies on the biology and therapy of cancer metastasis

1981 • 182 citations

Selection and altered properties of brain-colonising metastatic melanoma

1978 • 171 citations

Enzyme-containing Liposomes alleviate a Model for Storage Disease

1973 • 157 citations

Trauma and the localization of tumor cells

1967 • 155 citations

Metastatic behavior of a murine reticulum cell sarcoma exhibiting organ-specific growth.

1981 • 154 citations

Transpulmonary passage of tumor cell emboli.

1952 • 146 citations

Adhesion characteristics of murine metastatic and nonmetastatic tumor cells in vitro.

1980 • 133 citations

The fate of circulating tumors cells. I. Passage of cells through capillaries.

1961 • 130 citations

Relationship of host immune status to tumor cell arrest, distribution, and survival in experimental metastasis

1977 • 125 citations

Barrier function of lymph node to tumor cells and erythrocytes.I. Normal nodes

1967 • 117 citations

Implications of immunological heterogeneity of tumours

1979 • 117 citations

An experimental study of preferential metastasis

1960 • 111 citations

Cancer cell traffic from the lungs to the liver: An example of metastatic inefficiency

1980 • 108 citations

Metastasizing capacity of tumour cells from spontaneous metastases of transplanted murine tumours

1980 • 106 citations

The origin of metastatic heterogeneity in tumors

1981 • 98 citations

Liver-colonizing melanoma cells selected from B-16 melanoma

1979 • 93 citations

The role of fibronectin in adhesion of metastatic melanoma cells to endothelial cells and their basal lamina

1981 • 92 citations

Fate of Recirculating B16 Melanoma Metastatic Variant Cells in Parabiotic Syngeneic Recipients: Brief Communication 2

1977 • 90 citations

Tumor Metastasis Is Not Due to Adaptation of Cells to a New Organ Environment

1982 • 89 citations

A Treatise on Tumors

2018 • 87 citations

The organ distribution of disseminated 51 Cr-labeled tumor cells.

1967 • 84 citations

Hepatocyte-tumor cell interaction in vitro. I. Conditions for rosette formation and inhibition by anti-H-2 antibody.

1980 • 83 citations

Selection of malignant melanoma variant cell lines for ovary colonization

1979 • 83 citations

Organ vascularity and metastatic frequency.

1980 • 82 citations

Do Metastases Metastasize?

1971 • 80 citations

Characterization of a murine ovarian reticulum cell sarcoma of histiocytic origin.

1981 • 80 citations

Relationship between activity and amino sugar stereochemistry of daunorubicin and adriamycin derivatives.

1976 • 75 citations

THE RELATIONSHIP BETWEEN THE DISSEMINATION OF TUMOR CELLS AND THE DISTRIBUTION OF METASTASES.

1964 • 70 citations

EXPERIMENTAL STUDIES OF THE INTRAVASCULAR DISSEMINATION OF ASCITIC V2 CARCINOMA CELLS IN THE RABBIT, WITH SPECIAL REFERENCE TO FIBRINOGEN AND FIBRINOLYTIC AGENTS.

1964 • 69 citations

Murine melanoma: a model for intracranial metastasis

1980 • 67 citations

Detection of a cell-surface antigen correlated with organ-specific metastasis

1980 • 67 citations

Effect of Cytoskeleton-Disrupting Agents on the Metastatic Behavior of Melanoma Cells<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1980 • 65 citations

Environment of the blood-borne tumor embolus adherent to vessel wall.

1973 • 60 citations

Distribution of fibronectin on clonal cell lines of a rat mammary adenocarcinoma growing in vitro and in vivo at primary and metastatic sites.

1981 • 57 citations

Rat sarcoma model supports both "soil seed" and "mechanical" theories of metastatic spread

1976 • 46 citations

The effect of trypsin and neuraminidase on the circulation and organ distribution of tumor cells

1974 • 44 citations

Selection for virulence and organ‐specific metastasis of herpesvirus‐transformed lymphoma cells

1980 • 40 citations

Brief Communication: Organ-Specific Metastasis of a Transplantable Reticulum Cell Sarcoma2

1974 • 40 citations

Experimental Tumor Metastasis: Characteristics and Organ Specificity

1978 • 37 citations

A new metastasizing mammary carcinoma model in mice: Model characteristics and applications

1977 • 35 citations

The kinetics of the organ-specific metastasis of a transplantable reticuloendothelial tumor.

1969 • 32 citations

Tumor cell locomotion—a factor in metastasis formation? influence of cytochalasin b on a tumor dissemination pattern

1977 • 31 citations

Organ localization and the effect of trauma on the fate of circulating cancer cells.

1965 • 28 citations

The Fate of Circulating Walker 256 Tumour Cells injected Intravenously in Rats

1963 • 24 citations

Ovarian localization by embryonal teratocarcinoma cells derived from female germ gells

1979 • 22 citations

Influence of lodgement site on the proliferation of metastases of Walker 256 carcinoma in the rat

1978 • 21 citations

Laminin inhibits the adhesion of a murine tumor of macrophage origin

1982 • 19 citations

Observations on the effect of neuraminidase on the distribution of intravenously injected walker tumor cells in rats

1974 • 19 citations

Patterns of spontaneous metastasis of transplantable hepatocellular carcinomas.

1978 • 17 citations

The distribution of intravenously injected Kupffer cellsin the mouse.

1968 • 15 citations

Inhibition of Tritiated Thymidine Incorporation in Cultured Cells by Rat Kidney Extract<xref ref-type="fn" rid="FN2">2</xref>

1979 • 13 citations

Cancer Biology Reviews Vol 2

1982 • 8 citations

Changes with age in the homing properties and mitogen responses of lymphocytes from normal and leukemia-prone mice

1980 • 6 citations

Variation in the homing properties of 51Cr-labeled thy antigen-positive lymphoma

1980 • 2 citations

Deleted Work

1955 • 0 citations