Snf1 Protein Kinase Regulates Phosphorylation of the Mig1 Repressor in Saccharomyces cerevisiae

Experiments in molecular genetics

1972 • 28,260 citations

A novel genetic system to detect protein–protein interactions

1989 • 6,022 citations

Methods in Yeast Genetics: A Laboratory Course Manual

1990 • 1,922 citations

Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B

1993 • 802 citations

A Yeast Gene That Is Essential for Release from Glucose Repression Encodes a Protein Kinase

1986 • 688 citations

Ssn6-Tup1 is a general repressor of transcription in yeast

1992 • 680 citations

Comparison of the Saccharomyces cerevisiae G1 cyclins: Cln3 may be an upstream activator of Cln1, Cln2 and other cyclins.

1993 • 492 citations

Yeast MIG1 repressor is related to the mammalian early growth response and Wilms' tumour finger proteins.

1990 • 488 citations

DNA specificity of the bicoid activator protein is determined by homeodomain recognition helix residue 9

1989 • 487 citations

[76] β-d-Fructofuranoside fructohydrolase from yeast

1975 • 455 citations

Control of yeast GAL genes by MIG1 repressor: a transcriptional cascade in the glucose response.

1991 • 400 citations

Repression by SSN6-TUP1 is directed by MIG1, a repressor/activator protein.

1995 • 394 citations

Cell cycle control of the yeast HO gene: Cis- and Trans-acting regulators

1987 • 392 citations

Yeast SNF1 is functionally related to mammalian AMP-activated protein kinase and regulates acetyl-CoA carboxylase in vivo.

1994 • 388 citations

Glucose repression/derepression in budding yeast: SNF1 protein kinase is activated by phosphorylation under derepressing conditions, and this correlates with a high AMP:ATP ratio

1996 • 375 citations

Regulated nuclear translocation of the Mig1 glucose repressor.

1997 • 352 citations

Functional dissection of the yeast Cyc8–Tupl transcriptional co-repressor complex

1994 • 338 citations

Mammalian AMP-activated protein kinase shares structural and functional homology with the catalytic domain of yeast Snf1 protein kinase.

1994 • 330 citations

Similar substrate recognition motifs for mammalian AMP‐activated protein kinase, higher plant HMG‐CoA reductase kinase‐A, yeast SNF1, and mammalian calmodulin‐dependent protein kinase I

1995 • 322 citations

Specific association between the human DNA repair proteins XPA and ERCC1.

1994 • 304 citations

Glucose regulates protein interactions within the yeast SNF1 protein kinase complex.

1996 • 283 citations

Distinct TPR motifs of Cyc8 are involved in recruiting the Cyc8-Tup1 corepressor complex to differentially regulated promoters.

1995 • 258 citations

Mammalian AMP-activated protein kinase is homologous to yeast and plant protein kinases involved in the regulation of carbon metabolism

1994 • 251 citations

Multiple mechanisms provide rapid and stringent glucose repression of GAL gene expression in Saccharomyces cerevisiae.

1994 • 247 citations

Mutational analysis of the Saccharomyces cerevisiae SNF1 protein kinase and evidence for functional interaction with the SNF4 protein.

1989 • 236 citations

REG1 binds to protein phosphatase type 1 and regulates glucose repression in Saccharomyces cerevisiae.

1995 • 229 citations

The CYC8 and TUP1 proteins involved in glucose repression in Saccharomyces cerevisiae are associated in a protein complex.

1991 • 216 citations

Regulated expression of the GAL4 activator gene in yeast provides a sensitive genetic switch for glucose repression.

1991 • 211 citations

Characterization of TUP1, a mediator of glucose repression in Saccharomyces cerevisiae.

1990 • 207 citations

Upstream activation sites of the CYC1 gene of Saccharomyces cerevisiae are active when inverted but not when placed downstream of the "TATA box".

1984 • 204 citations

Glucose-regulated interaction of a regulatory subunit of protein phosphatase 1 with the Snf1 protein kinase in Saccharomyces cerevisiae

1998 • 198 citations

Molecular analysis of SSN6, a gene functionally related to the SNF1 protein kinase of Saccharomyces cerevisiae.

1987 • 192 citations

Cloning and genetic mapping of SNF1, a gene required for expression of glucose-repressible genes in Saccharomyces cerevisiae.

1984 • 165 citations

Two Zinc-Finger-Containing Repressors Are Responsible for Glucose Repression of SUC2 Expression

1996 • 162 citations

Rgt1p of Saccharomyces cerevisiae, a Key Regulator of Glucose-Induced Genes, Is both an Activator and a Repressor of Transcription

1996 • 153 citations

A family of proteins containing a conserved domain that mediates interaction with the yeast SNF1 protein kinase complex.

1994 • 143 citations

The Rox1 repressor of the Saccharomyces cerevisiae hypoxic genes is a specific DNA-binding protein with a high-mobility-group motif.

1993 • 142 citations

Negative control of the Mig1p repressor by Snf1p‐dependent phosphorylation in the absence of glucose

1998 • 135 citations

The Cyc8 (Ssn6)-Tup1 Corepressor Complex Is Composed of One Cyc8 and Four Tup1 Subunits

1996 • 132 citations

Isolation of crt mutants constitutive for transcription of the DNA damage inducible gene RNR3 in Saccharomyces cerevisiae.

1992 • 127 citations

LexA protein is a repressor of the colicin E1 gene.

1983 • 126 citations

The N-terminal TPR region is the functional domain of SSN6, a nuclear phosphoprotein of Saccharomyces cerevisiae.

1990 • 124 citations

Oncogenic transformation by vrel requires an amino-terminal activation domain.

1990 • 123 citations

N-terminal mutations modulate yeast SNF1 protein kinase function.

1992 • 121 citations

Sfh1p, a Component of a Novel Chromatin-Remodeling Complex, Is Required for Cell Cycle Progression

1997 • 120 citations

Transcriptional repression directed by the yeast α2 protein in vitro

1994 • 118 citations

Functional Domains in the Mig1 Repressor

1996 • 110 citations

Positive Control of Yeast Meiotic Genes by the Negative Regulator UME6

1995 • 105 citations

Synergistic release from glucose repression by mig1 and ssn mutations in Saccharomyces cerevisiae.

1994 • 105 citations

A Complex Composed of Tup1 and Ssn6 Represses Transcription in Vitro

1997 • 103 citations

Two Different Repressors Collaborate To Restrict Expression of the Yeast Glucose Transporter Genes HXT2 and HXT4 to Low Levels of Glucose

1996 • 102 citations

MIG1-dependent and MIG1-independent glucose regulation of MAL gene expression in Saccharomyces cerevisiae

1995 • 101 citations

Expression of the SUC2 Gene of Saccharomyces cerevisiae is Induced by Low Levels of Glucose

1997 • 98 citations

Chromatin-mediated transcription repression in yeast

1995 • 94 citations

Cloning and characterization of the CYC8 gene mediating glucose repression in yeast

1988 • 87 citations

Expression of theSUC2 Gene ofSaccharomyces cerevisiae is Induced by Low Levels of Glucose

1997 • 87 citations

AAR1/TUP1 Protein, with a Structure Similar to That of the β Subunit of G Proteins, Is Required for a1-α2 and α2 Repression in Cell Type Control of Saccharomyces cerevisiae

1991 • 82 citations

Extragenic suppressors of yeast glucose derepression mutants leading to constitutive synthesis of several glucose-repressible enzymes

1991 • 74 citations

Characterization of TUP1, a Mediator of Glucose Repression in Saccharomyces cerevisiae

1990 • 63 citations

Multiple Mechanisms Provide Rapid and Stringent Glucose Repression of GAL Gene Expression in Saccharomyces cerevisiae

1994 • 62 citations

Mutational Analysis of the Saccharomyces cerevisiae SNF1 Protein Kinase and Evidence for Functional Interaction with the SNF4 Protein

1989 • 59 citations

Molecular Analysis of SSN6, a Gene Functionally Related to the SNF1 Protein Kinase of Saccharomyces cerevisiae

1987 • 53 citations

Oncogenic Transformation by vRel Requires an Amino-Terminal Activation Domain

1990 • 49 citations

Analysis of URSG-mediated glucose repression of the GAL1 promoter of Saccharomyces cerevisiae.

1992 • 48 citations

The Rox1 Repressor of the Saccharomyces cerevisiae Hypoxic Genes is a Specific DNA-Binding Protein with a High-Mobility-Group Motif

1993 • 46 citations

The N-Terminal TPR Region Is the Functional Domain of SSN6, a Nuclear Phosphoprotein of Saccharomyces cerevisiae

1990 • 37 citations

Cloning and Genetic Mapping of SNF1, a Gene Required for Expression of Glucose-Repressible Genes in Saccharomyces cerevisiae

1984 • 36 citations

Comparative analysis in three fungi reveals structurally and functionally conserved regions in the Mig1 repressor

1997 • 33 citations

Removal of a Mig1p Binding Site Converts a MAL63 Constitutive Mutant Derived by Interchromosomal Gene Conversion to Glucose Insensitivity

1996 • 21 citations

The yeast alpha 2 protein can repress transcription by RNA polymerases I and II but not III.

1993 • 18 citations

The Yeast α2 Protein Can Repress Transcription by RNA Polymerases I and II but Not III

1993 • 4 citations