Phase I study to determine the safety and pharmacokinetics of the novel Raf kinase and VEGFR inhibitor BAY 43-9006, administered for 28 days on/7 days off in patients with advanced, refractory solid tumors

BAY 43-9006 Exhibits Broad Spectrum Oral Antitumor Activity and Targets the RAF/MEK/ERK Pathway and Receptor Tyrosine Kinases Involved in Tumor Progression and Angiogenesis

2004 • 3,873 citations

Clinical translation of angiogenesis inhibitors

2002 • 1,518 citations

The role of angiogenesis in tumor growth.

1992 • 1,267 citations

BRAF and RAS mutations in human lung cancer and melanoma.

2002 • 979 citations

Phase I Clinical and Pharmacokinetic Study of the Novel Raf Kinase and Vascular Endothelial Growth Factor Receptor Inhibitor BAY 43-9006 in Patients With Advanced Refractory Solid Tumors

2004 • 855 citations

Common toxicity criteria: version 2.0. an improved reference for grading the acute effects of cancer treatment: impact on radiotherapy

2000 • 800 citations

Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors.

2002 • 432 citations

Discovery of a novel Raf kinase inhibitor.

2001 • 417 citations

Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK–ERK independent mechanism

2001 • 311 citations

BAY 43-9006: Preclinical Data

2002 • 289 citations

Oncogenes and tumor angiogenesis: differential modes of vascular endothelial growth factor up-regulation in ras-transformed epithelial cells and fibroblasts.

2000 • 234 citations

Overproduction of Vascular Endothelial Growth Factor Related to von Hippel-Lindau Tumor Suppressor Gene Mutations and Hypoxia-Inducible Factor-1α Expression in Renal Cell Carcinomas.

2003 • 194 citations

Autocrine and paracrine functions of vascular endothelial growth factor (VEGF) in renal tubular epithelial cells

2005 • 104 citations

VEGF Stimulates MAPK through a Pathway That Is Unique for Receptor Tyrosine Kinases

1999 • 102 citations

The Raf signal transduction cascade as a target for chemotherapeutic intervention in growth factor-responsive tumors

2000 • 97 citations

Disruption of the Rb-Raf-1 Interaction Inhibits Tumor Growth and Angiogenesis

2004 • 96 citations

Raf and the road to cell survival: a tale of bad spells, ring bearers and detours

2003 • 68 citations

Ras regulation of vascular endothelial growth factor and angiogenesis

2001 • 57 citations

Targeting new anticancer drugs within signalling pathways regulated by the Ras GTPase superfamily (Review)

2001 • 20 citations

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