Raf and the road to cell survival: a tale of bad spells, ring bearers and detours

IAP proteins: blocking the road to death's door

2002 • 1,753 citations

Mechanisms of Caspase Activation and Inhibition during Apoptosis

2002 • 1,731 citations

Oncogenic alterations of metabolism

1999 • 1,095 citations

Life-or-death decisions by the Bcl-2 protein family

2001 • 887 citations

Cloning and functional analysis of BAG-1: A novel Bcl-2-binding protein with anti-cell death activity

1995 • 863 citations

Bcl-2 Targets the Protein Kinase Raf-1 to Mitochondria

1996 • 785 citations

The ins and outs of Raf kinases

1994 • 537 citations

The mitochondrial apoptosome: a killer unleashed by the cytochrome seas

2001 • 514 citations

The Apaf-1 apoptosome: a large caspase-activating complex

2002 • 424 citations

Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1.

1996 • 364 citations

p21-Activated Kinase 1 Phosphorylates the Death Agonist Bad and Protects Cells from Apoptosis

2000 • 356 citations

Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene

2001 • 311 citations

B-Raf Inhibits Programmed Cell Death Downstream of Cytochrome c Release from Mitochondria by Activating the MEK/Erk Pathway

1999 • 311 citations

MEK kinase activity is not necessary for Raf-1 function

2001 • 308 citations

The MAGE proteins: Emerging roles in cell cycle progression, apoptosis, and neurogenetic disease

2002 • 308 citations

Endothelial apoptosis in Braf-deficient mice

1997 • 291 citations

Cdc2 Phosphorylation of BAD Links the Cell Cycle to the Cell Death Machinery

2002 • 285 citations

Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155

2000 • 275 citations

Molecular signaling in death receptor and mitochondrial pathways of apoptosis (Review)

2003 • 259 citations

VDAC, a Channel in the Outer Mitochondrial Membrane

1996 • 252 citations

JNK Phosphorylation and Activation of BAD Couples the Stress-activated Signaling Pathway to the Cell Death Machinery

2002 • 244 citations

How BAD phosphorylation is good for survival

1999 • 242 citations

Activation of Rac GTPase by p75 Is Necessary for c-junN-Terminal Kinase-Mediated Apoptosis

2002 • 203 citations

Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155

2000 • 181 citations

Apoptosis Suppression by Raf-1 and MEK1 Requires MEK- and Phosphatidylinositol 3-Kinase-Dependent Signals

2001 • 181 citations

Homologous cell-derived oncogenes in avian carcinoma virus MH2 and murine sarcoma virus 3611

1984 • 121 citations

Mechanisms and control of programmed cell death in invertebrates

1998 • 119 citations

Craf-1 protein kinase is essential for mouse development

1998 • 116 citations

v-raf suppresses apoptosis and promotes growth of interleukin-3-dependent myeloid cells.

1994 • 111 citations

Specific function of B-Raf in mediating survival of embryonic motoneurons and sensory neurons

2001 • 109 citations

Neurotrophin Receptor-interacting Mage Homologue Is an Inducible Inhibitor of Apoptosis Protein-interacting Protein That Augments Cell Death

2001 • 89 citations

Evidence for a Role of Mixed Lineage Kinases in Neuronal Apoptosis

2001 • 87 citations

Activation of apoptosis associated with enforced myc expression in myeloid progenitor cells is dominant to the suppression of apoptosis by interleukin-3 or erythropoietin

1993 • 70 citations

Negative regulation of mitochondrial VDAC channels by C-Raf kinase.

2002 • 65 citations

Independent control of cell survival by Raf-1 and Bcl-2 at the mitochondria

2001 • 58 citations

Differential regulation of Raf isozymes by growth versus differentiation inducing factors in PC12 pheochromocytoma cells

1996 • 51 citations

Regulation of glycolysis by Raf protein serine/threonine kinases

2002 • 48 citations

NRAGE and the cycling side of the neurotrophin receptor p75

2000 • 26 citations

Bcl-2 determines susceptibility to induction of lung cancer by oncogenic CRaf.

2002 • 26 citations

Abrogation of IL-3 Dependence of Myeloid FDC-P1 Cells by Tyrosine Kinase Oncogenes Is Associated with Induction of c-myc

1988 • 7 citations