Disruption of the Rb-Raf-1 Interaction Inhibits Tumor Growth and Angiogenesis

Mutations of the BRAF gene in human cancer

2002 • 10,249 citations

The biology of VEGF and its receptors

2003 • 9,272 citations

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

Rb-Mediated Heterochromatin Formation and Silencing of E2F Target Genes during Cellular Senescence

2003 • 2,104 citations

Glycogen synthase kinase-3β regulates cyclin D1 proteolysis and subcellular localization

1998 • 2,096 citations

The third helix of the Antennapedia homeodomain translocates through biological membranes.

1994 • 1,964 citations

The E2F transcription factor is a cellular target for the RB protein

1991 • 1,461 citations

To cycle or not to cycle: a critical decision in cancer

2001 • 1,429 citations

Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

2000 • 1,398 citations

Retinoblastoma protein recruits histone deacetylase to repress transcription

1998 • 1,231 citations

EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer

2003 • 1,147 citations

D-type cyclin-dependent kinase activity in mammalian cells.

1994 • 1,073 citations

Recycling the Cell Cycle

2004 • 1,032 citations

Cdk Phosphorylation Triggers Sequential Intramolecular Interactions that Progressively Block Rb Functions as Cells Move through G1

1999 • 1,028 citations

The Rb/E2F pathway and cancer

2001 • 913 citations

Rb targets histone H3 methylation and HP1 to promoters

2001 • 892 citations

Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP

1999 • 850 citations

Tumor Regression by Targeted Gene Delivery to the Neovasculature

2002 • 848 citations

Tumor suppression by Ink4a–Arf: progress and puzzles

2003 • 700 citations

The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest

1994 • 625 citations

Apaf-1 is a transcriptional target for E2F and p53

2001 • 590 citations

Proliferation of cancer cells despite CDK2 inhibition

2003 • 458 citations

A revised picture of the E2F transcriptional network and RB function

2002 • 422 citations

Retinoblastoma protein partners

2001 • 348 citations

Prohibitin Induces the Transcriptional Activity of p53 and Is Exported from the Nucleus upon Apoptotic Signaling

2003 • 335 citations

Role of Raf in Vascular Protection from Distinct Apoptotic Stimuli

2003 • 334 citations

Convergence of Mitogenic Signalling Cascades from Diverse Classes of Receptors at the Cyclin D–Cyclin-Dependent Kinase–pRb-Controlled G₁ Checkpoint

1996 • 331 citations

D-Type Cyclin-Dependent Kinase Activity in Mammalian Cells

1994 • 322 citations

Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK–ERK independent mechanism

2001 • 311 citations

MEK kinase activity is not necessary for Raf-1 function

2001 • 308 citations

The genetics of the E2F family of transcription factors: shared functions and unique roles

2002 • 301 citations

Coordinated regulation of life and death by RB

2003 • 290 citations

The Ras-Raf-MEK-ERK Pathway in the Treatment of Cancer

2002 • 265 citations

Differential regulation of E2F1 apoptotic target genes in response to DNA damage

2003 • 262 citations

Positive and negative regulation of Raf kinase activity and function by phosphorylation

2001 • 257 citations

RAS pathways to cell cycle control and cell transformation

1998 • 247 citations

BRG-1 is required for RB-mediated cell cycle arrest

2000 • 245 citations

Prohibitin, a potential tumor suppressor, interacts with RB and regulates E2F function

1999 • 233 citations

Identification and Characterization of E2F7, a Novel Mammalian E2F Family Member Capable of Blocking Cellular Proliferation

2003 • 220 citations

Prohibitin co-localizes with Rb in the nucleus and recruits N-CoR and HDAC1 for transcriptional repression

2002 • 220 citations

Inhibition of DNA synthesis by RB: effects on G₁/S transition and S-phase progression

1998 • 209 citations

Linking the Rb and Polycomb Pathways

2001 • 188 citations

Role of the LXCXE Binding Site in Rb Function

2000 • 162 citations

Life and death decisions by E2F-1

2003 • 162 citations

Design of GFB-111, a platelet-derived growth factor binding molecule with antiangiogenic and anticancer activity against human tumors in mice

2000 • 139 citations

Chromatin remodeling and Rb activity

2000 • 138 citations

Induction of p21^WAF1/CIP1 and Inhibition of Cdk2 Mediated by the Tumor Suppressor p16^INK4a

1999 • 126 citations

Regulation of Rb and E2F by signal transduction cascades: divergent effects of JNK1 and p38 kinases

1999 • 121 citations

Raf-1 Physically Interacts with Rb and Regulates Its Function: a Link between Mitogenic Signaling and Cell Cycle Regulation

1998 • 119 citations

Active Localization of the Retinoblastoma Protein in Chromatin and Its Response to S Phase DNA Damage

2003 • 114 citations

The yin and yang of E2F-1: balancing life and death

2003 • 106 citations

Differential regulation of Rb family proteins and prohibitin during camptothecin-induced apoptosis

2002 • 105 citations

Antiangiogenic effects of the quinoline-3-carboxamide linomide.

1993 • 104 citations

Identification of Novel E2F1-Regulated Genes by Microarray

2002 • 101 citations

Histone Deacetylation of RB-Responsive Promoters: Requisite for Specific Gene Repression but Dispensable for Cell Cycle Inhibition

2003 • 78 citations

Uncoupling Raf1 from MEK1/2 Impairs Only a Subset of Cellular Responses to Raf Activation

2000 • 72 citations

The Retinoblastoma Protein Is Linked to the Activation of Ras

1999 • 69 citations

A putative coiled-coil domain of prohibitin is sufficient to repress E2F1-mediated transcription and induce apoptosis

2003 • 59 citations

E2F: a nodal point in cell cycle regulation

1997 • 48 citations

Vascular endothelial growth factor (VEGF) activates Raf-1, mitogen-activated protein (MAP) kinases, and S6 kinase (p90rsk) in cultured rat cardiac myocytes

1998 • 48 citations

Active RB Elicits Late G1/S Inhibition

2002 • 39 citations

Inactivation of Retinoblastoma (RB) Tumor Suppressor by Oncogenic Isoforms of the p53 Family Member p73

2003 • 36 citations

Ras Inactivation of the Retinoblastoma Pathway by Distinct Mechanisms in NIH 3T3 Fibroblast and RIE-1 Epithelial Cells

2000 • 34 citations

HLA Class I-Mediated Induction of Cell Proliferation Involves Cyclin E-Mediated Inactivation of Rb Function and Induction of E2F Activity

1999 • 32 citations

Cyclin D-Cdk4 Is Not a Master Regulator of Cell Multiplication in Drosophila Embryos

2002 • 30 citations

Lipophilization of somatostatin analog RC-160 with long chain fatty acid improves its anti-proliferative activity on human oral carcinoma cells in vitro

2000 • 11 citations