Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors.
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References (49)
Cell Signaling by Receptor Tyrosine Kinases
2010 • 7,477 citations
Efficacy and Safety of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in Chronic Myeloid Leukemia
2001 • 5,189 citations
Activity of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in the Blast Crisis of Chronic Myeloid Leukemia and Acute Lymphoblastic Leukemia with the Philadelphia Chromosome
2001 • 2,749 citations
Mechanism of Action and In Vivo Role of Platelet-Derived Growth Factor
1999 • 2,386 citations
Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
1995 • 2,106 citations
The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
1995 • 2,024 citations
Malignant glioma: genetics and biology of a grave matter
2001 • 1,229 citations
PLATELET-DERIVED GROWTH FACTOR
1989 • 967 citations
PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo
2001 • 708 citations
Platelet-derived growth factor and its receptors in human glioma tissue: expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops.
1992 • 689 citations
PDGF-C is a new protease-activated ligand for the PDGF α-receptor
2000 • 612 citations
Platelet-derived growth factor receptor signals.
1994 • 561 citations
PDGF-D is a specific, protease-activated ligand for the PDGF β-receptor
2001 • 542 citations
Platelet-derived growth factor: mechanism of action and possible in vivo function.
1990 • 491 citations
PDGF-D, a new protease-activated growth factor
2001 • 389 citations
Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumors.
1992 • 380 citations
Developmental roles of platelet‐derived growth factors
2001 • 365 citations
Expression of messenger RNAs for platelet-derived growth factor and transforming growth factor-alpha and their receptors in human malignant glioma cell lines.
1988 • 354 citations
Intracranial inhibition of platelet-derived growth factor-mediated glioblastoma cell growth by an orally active kinase inhibitor of the 2-phenylaminopyrimidine class.
2000 • 312 citations
Expression of PDGF and PDGF receptors in human astrocytoma operation specimens supports the existence of an autocrine loop
1995 • 298 citations
Induction of brain tumors in mice using a recombinant platelet-derived growth factor B-chain retrovirus.
1998 • 290 citations
Platelet-derived Growth Factor C (PDGF-C), a Novel Growth Factor That Binds to PDGF α and β Receptor
2001 • 278 citations
Transforming protein of simian sarcoma virus stimulates autocrine growth of SSV-transformed cells through PDGF cell-surface receptors
1984 • 277 citations
Growth factors in glioma angiogenesis: FGFs, PDGF, EGF, and TGFs.
2000 • 238 citations
Platelet‐derived growth factor in human glioma
1995 • 196 citations
Transformation of NIH 3T3 cells by a human c-sis cDNA clone
1984 • 181 citations
Brain and other central nervous system tumors: rates, trends, and epidemiology
2001 • 179 citations
Expression of the normal human sis/PDGF-2 coding sequence induces cellular transformation
1984 • 170 citations
Dominant-negative mutants of platelet-derived growth factor revert the transformed phenotype of human astrocytoma cells.
1993 • 155 citations
Inhibition of glioma cell growth by a truncated platelet-derived growth factor-beta receptor.
1994 • 116 citations
Activated platelet‐derived growth factor autocrine pathway drives the transformed phenotype of a human glioblastoma cell line
1994 • 105 citations
Inhibition of v-fms-induced tumor growth in nude mice by castanospermine.
1988 • 88 citations
Autocrine growth stimulation of human meningioma cells by platelet-derived growth factor
1996 • 72 citations
Expression of recombinant platelet-derived growth factor A- and B-chain homodimers in rat-1 cells and human fibroblasts reveals differences in protein processing and autocrine effects.
1988 • 71 citations
Biology and treatment of malignant glioma.
1998 • 62 citations
Growth factor requirements of oncogene-transformed NIH 3T3 and BALB/c 3T3 cells cultured in defined media.
1986 • 62 citations
Molecular Localization of the Transforming and Secretory Properties of PDGF A and PDGF B
1990 • 60 citations
Colony‐stimulating factor‐1 receptor (c‐fms)
1988 • 55 citations
Molecular Genetics of Brain Tumors
1999 • 54 citations
Reversion of autocrine transformation by a dominant negative platelet-derived growth factor mutant.
1993 • 52 citations
The amino-terminal domain of the v-fms oncogene product includes a functional signal peptide that directs synthesis of a transforming glycoprotein in the absence of feline leukemia virus gag sequences
1986 • 45 citations
Platelet-derived growth factor-B/v-sis confers a tumorigenic and metastatic phenotype to human T98G glioblastoma cells.
1996 • 45 citations
Efficacy of the novel selective platelet-derived growth factor receptor antagonist CT52923 on cellular proliferation, migration, and suppression of neointima following vascular injury.
2001 • 38 citations
Molecular genetics of human glioma
1995 • 38 citations
Platelet–derived growth factor (PDGF) and receptor (PDGFR) expression in human meningiomas: correlations with clinicopathological features and cytogenetic analysis
1994 • 34 citations
Platelet-derived growth factor (PDGF) receptor activation in cell transformation and human malignancy
1992 • 21 citations
Control of meningioma cell growth by platelet-derived growth factor (PDGF)
1995 • 20 citations
Invasiveness and chemotactic activity of oncogene transformed NIH/3T3 cells.
1990 • 18 citations
Role of phosphoinositide 3OH‐kinase in autocrine transformation by PDGF‐BB*
2001 • 11 citations
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