Hyperexpression of CD40 ligand by B and T cells in human lupus and its role in pathogenic autoantibody production.

Generation of single-stranded DNA by the polymerase chain reaction and its application to direct sequencing of the HLA-DQA locus.

1988 • 1,582 citations

The CD40 Antigen and its Ligand

1994 • 1,259 citations

Mechanism of antigen-driven selection in germinal centres

1989 • 1,097 citations

A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells.

1992 • 818 citations

Reliability and validity of six systems for the clinical assessment of disease activity in systemic lupus erythematosus

1989 • 792 citations

Treatment of Murine Lupus with CTLA4Ig

1994 • 683 citations

How B and T cells talk to each other

1994 • 659 citations

Nucleosome: a major immunogen for pathogenic autoantibody-inducing T cells of lupus.

1993 • 637 citations

Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal.

1993 • 622 citations

gp39-CD40 interactions are essential for germinal center formation and the development of B cell memory.

1994 • 431 citations

Recombinant human CD40 ligand stimulates B cell proliferation and immunoglobulin E secretion.

1992 • 409 citations

T cell receptor alpha/beta expressing double-negative (CD4-/CD8-) and CD4+ T helper cells in humans augment the production of pathogenic anti-DNA autoantibodies associated with lupus nephritis.

1989 • 402 citations

B-cell apoptosis induced by antigen receptor crosslinking is blocked by a T-cell signal through CD40

1993 • 390 citations

The regulation of the expression of gp39, the CD40 ligand, on normal and cloned CD4+ T cells.

1993 • 384 citations

Interaction between CD40 and its ligand gp39 in the development of murine lupus nephritis.

1995 • 371 citations

Immunoglobulin epitope spreading and autoimmune disease after peptide immunization: Sm B/B'-derived PPPGMRPP and PPPGIRGP induce spliceosome autoimmunity.

1995 • 338 citations

Systemic autoimmune disease arises from polyclonal B cell activation.

1987 • 314 citations

The central role of chromatin in autoimmune responses to histones and DNA in systemic lupus erythematosus.

1994 • 307 citations

CD40 ligation induces Apo-1/Fas expression on human B lymphocytes and facilitates apoptosis through the Apo-1/Fas pathway.

1995 • 285 citations

Th2-like CD8+ T cells showing B cell helper function and reduced cytolytic activity in human immunodeficiency virus type 1 infection.

1994 • 276 citations

A systemic lupus erythematosus (SLE)‐like disease in mice induced by abnormal T‐B cell cooperation. Preferential formation of autoantibodies characteristic of SLE

1982 • 267 citations

The Role of Somatic Mutation in the Pathogenic Anti-DNA Response

1992 • 244 citations

Signal transduction via CD40 involves activation of lyn kinase and phosphatidylinositol-3-kinase, and phosphorylation of phospholipase C gamma 2.

1994 • 238 citations

Induction of a cationic shift in IgG anti-DNA autoantibodies. Role of T helper cells with classical and novel phenotypes in three murine models of lupus nephritis.

1987 • 236 citations

B cells process and present lupus autoantigens that initiate autoimmune T cell responses.

1994 • 236 citations

Genesis and evolution of antichromatin autoantibodies in murine lupus implicates T-dependent immunization with self antigen.

1993 • 234 citations

CD40 molecules induce down-modulation and endocytosis of T cell surface T cell-B cell activating molecule/CD40-L. Potential role in regulating helper effector function.

1994 • 205 citations

Pathogenic anti-DNA autoantibody-inducing T helper cell lines from patients with active lupus nephritis: isolation of CD4-8- T helper cell lines that express the gamma delta T-cell antigen receptor.

1990 • 205 citations

The CD40 ligand expressed by human B cells costimulates B cell responses.

1995 • 200 citations

Molecular interactions mediating T-B lymphocyte collaboration in human lymphoid follicles. Roles of T cell-B-cell-activating molecule (5c8 antigen) and CD40 in contact-dependent help.

1992 • 194 citations

The Relation of Immunoglobulin Class, Pattern of Antinuclear Antibody, and Complement-Fixing Antibodies to DNA in Sera from Patients with Systemic Lupus Erythematosus*

1967 • 174 citations

Tumor necrosis factor (TNF) receptor expression in T lymphocytes. Differential regulation of the type I TNF receptor during activation of resting and effector T cells.

1991 • 174 citations

TCR/CD3 complex-mediated signal transduction pathway in T cells and T cell lines from patients with systemic lupus erythematosus.

1995 • 168 citations

Structure and specificity of T cell receptors expressed by potentially pathogenic anti-DNA autoantibody-inducing T cells in human lupus.

1995 • 165 citations

Diminished expression of CD40 ligand by activated neonatal T cells.

1995 • 159 citations

B cells regulate expression of CD40 ligand on activated T cells by lowering the mRNA level and through the release of soluble CD40

1994 • 157 citations

Regulation of expression of the ligand for CD40 on T helper lymphocytes.

1993 • 155 citations

Costimulation through CD28 enhances T cell-dependent B cell activation via CD40-CD40L interaction.

1994 • 154 citations

Antigen-specific induction of antibodies against native mammalian DNA in nonautoimmune mice.

1993 • 152 citations

In the absence of a CD40 signal, B cells are tolerogenic

1995 • 149 citations

Induction of B cell costimulatory function by recombinant murine CD40 ligand

1994 • 148 citations

T cell determinants from autoantibodies to DNA can upregulate autoimmunity in murine systemic lupus erythematosus.

1995 • 148 citations

Mechanisms of T and B cell collaboration in the in vitro production of anti-DNA antibodies in the NZB/NZW F1 murine SLE model.

1987 • 145 citations

CD40 signaling pathway: anti-CD40 monoclonal antibody induces rapid dephosphorylation and phosphorylation of tyrosine-phosphorylated proteins including protein tyrosine kinase Lyn, Fyn, and Syk and the appearance of a 28-kD tyrosine phosphorylated protein.

1994 • 134 citations

Induction of bcl-x by CD40 engagement rescues sIg-induced apoptosis in murine B cells.

1995 • 129 citations

CD8+ Lymphocytes from patients with systemic lupus erythematosus sustain, rather than suppress, spontaneous polyclonal IgG production and synergize with CD4+ cells to support autoantibody synthesis

1990 • 120 citations

T-BAM/CD40-L on helper T lymphocytes augments lymphokine-induced B cell Ig isotype switch recombination and rescues B cells from programmed cell death.

1994 • 117 citations

Development of autoimmune disease in SCID mice populated with long-term "in vitro" proliferating (NZB x NZW)F1 pre-B cells.

1992 • 116 citations

Immunohistologic analysis of ineffective CD40-CD40 ligand interaction in lymphoid tissues from patients with X-linked immunodeficiency with hyper-IgM. Abortive germinal center cell reaction and severe depletion of follicular dendritic cells.

1995 • 112 citations

In vivo expression of a single viral DNA-binding protein generates systemic lupus erythematosus-related autoimmunity to double-stranded DNA and histones.

1995 • 110 citations

The NZB X SWR model of lupus nephritis. II. Autoantibodies deposited in renal lesions show a distinctive and restricted idiotypic diversity.

1987 • 102 citations

Immunohistologic analysis of ineffective CD40-CD40 ligand interaction in lymphoid tissues from patients with X-linked immunodeficiency with hyper-IgM. Abortive germinal center cell reaction and severe depletion of follicular dendritic cells.

1995 • 100 citations

Junctional region sequences of T-cell receptor beta-chain genes expressed by pathogenic anti-DNA autoantibody-inducing helper T cells from lupus mice: possible selection by cationic autoantigens.

1991 • 90 citations

Deficient type I protein kinase A isozyme activity in systemic lupus erythematosus T lymphocytes.

1994 • 90 citations

The CD40 Antigen and Its Ligand

1994 • 82 citations

CD4+ T cell lines with selective patterns of autoreactivity as well as CD4- CD8- T helper cell lines augment the production of idiotypes shared by pathogenic anti-DNA autoantibodies in the NZB x SWR model of lupus nephritis.

1988 • 78 citations

T-B collaboration for autoantibody production in lpr mice is cognate and MHC-restricted.

1994 • 76 citations

Possible pathogenic role of cationic anti-DNA autoantibodies in the development of nephritis in patients with systemic lupus erythematosus.

1993 • 72 citations

Analysis of recombinant inbred lines derived from "autoimmune" (NZB) and "high leukemia" (C58) strains: independent multigenic systems control B cell hyperactivity, retrovirus expression, and autoimmunity.

1982 • 69 citations

T and B cell collaboration is essential for the autoantibody response to DNA topoisomerase I in systemic sclerosis.

1995 • 67 citations

Cross-reactivity distinguishes serum and nephritogenic anti-DNA antibodies in human lupus from their natural counterparts in normal serum

1990 • 67 citations

Polyclonal B cell activation arises from different mechanisms in lupus-prone (NZB x NZW)F1 and MRL/MpJ-lpr/lpr mice.

1993 • 60 citations

Autoantigen-specific T cell proliferation induced by the ribosomal P2 protein in patients with systemic lupus erythematosus.

1994 • 51 citations

Generation and characterization of cloned T helper cell lines for anti-DNA responses in NZB.H-2bm12 mice.

1992 • 50 citations

IgG but not other classes of anti-[(H2A-H2B)-DNA] is an early sign of procainamide-induced lupus.

1995 • 46 citations

T cell receptor alpha-chain repertoire of pathogenic autoantibody-inducing T cells in lupus mice.

1994 • 35 citations

Murine lupus glomerulotropic monoclonal antibodies exhibit differing specificities but bind via a common mechanism.

1995 • 34 citations

IMMUNOHISTOLOGIC ANALYSIS OF INEFFECTIVE CD40-CD40 LIGAND INTERACTION IN LYMPHOID TISSUES FROM PATIENTS WITH X-LINKED IMMUNODEFICIENCY WITH HYPER-IgM

1996 • 34 citations

Cationic and high affinity serum IgG anti-dsDNA antibodies in active lupus nephritis

1993 • 31 citations

Structure of the murine CD40 ligand gene

1994 • 29 citations

The Role Of Somatic Mutation In The Pathogenic Anti-DNA Response

1992 • 18 citations

Mechanisms of autoimmunization: Perspective from the mid-90s

1994 • 17 citations

Mechanisms of the pathogenic autoimmune response in lupus: Prospects for specific immunotherapy

1995 • 11 citations