Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase–1

The Metabolic Phenotype in Obesity: Fat Mass, Body Fat Distribution, and Adipose Tissue Function

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Obesity as a medical problem

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A RELATION BETWEEN NON-ESTERIFIED FATTY ACIDS IN PLASMA AND THE METABOLISM OF GLUCOSE

1956 • 3,458 citations

Loss of stearoyl–CoA desaturase-1 function protects mice against adiposity

2002 • 1,066 citations

Role for Stearoyl-CoA Desaturase-1 in Leptin-Mediated Weight Loss

2002 • 825 citations

Regulation of stearoyl-CoA desaturases and role in metabolism

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Mechanism of rat liver microsomal stearyl-CoA desaturase. Studies of the substrate specificity, enzyme-substrate interactions, and the function of lipid.

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The Biosynthesis of Hepatic Cholesterol Esters and Triglycerides Is Impaired in Mice with a Disruption of the Gene for Stearoyl-CoA Desaturase 1

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Mitochondrial and peroxisomal fatty acid oxidation in liver homogenates and isolated hepatocytes from control and clofibrate-treated rats.

1979 • 436 citations

Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver

2004 • 378 citations

2′-O-(2-Methoxy)ethyl-modified Anti-intercellular Adhesion Molecule 1 (ICAM-1) Oligonucleotides Selectively Increase the ICAM-1 mRNA Level and Inhibit Formation of the ICAM-1 Translation Initiation Complex in Human Umbilical Vein Endothelial Cells

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Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia

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The regulation of stearoyl-CoA desaturase (SCD)

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Role of resistin in diet-induced hepatic insulin resistance

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Role of resistin in diet-induced hepatic insulin resistance

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Dietary regulation of stearoyl-CoA desaturase 1 gene expression in mouse liver.

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The role of malonyl-coa in the coordination of fatty acid synthesis and oxidation in isolated rat hepatocytes.

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Human stearoyl-CoA desaturase: alternative transcripts generated from a single gene by usage of tandem polyadenylation sites

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Identification and Characterization of Murine SCD4, a Novel Heart-specific Stearoyl-CoA Desaturase Isoform Regulated by Leptin and Dietary Factors

2003 • 201 citations

Scd3—A Novel Gene of the Stearoyl-CoA Desaturase Family with Restricted Expression in Skin

2001 • 188 citations

Site and mechanism of leptin action in a rodent form of congenital lipodystrophy

2004 • 182 citations

Stearoyl-CoA desaturase 1 deficiency elevates insulin-signaling components and down-regulates protein-tyrosine phosphatase 1B in muscle

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Site and mechanism of leptin action in a rodent form of congenital lipodystrophy

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Insulin and dietary fructose induce stearoyl-CoA desaturase 1 gene expression of diabetic mice.

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Lack of stearoyl-CoA desaturase 1 upregulates basal thermogenesis but causes hypothermia in a cold environment

2004 • 124 citations

The Role of Stearoyl-CoA Desaturase in Body Weight Regulation

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Potentiation of Insulin Signaling in Tissues of Zucker Obese Rats After Acute and Long-Term Treatment With PPARγ Agonists

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Stearoyl-CoA Desaturase-1 and the Metabolic Syndrome

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Human stearoyl-CoA desaturase: alternative transcripts generated from a single gene by usage of tandem polyadenylation sites

1999 • 95 citations

Identification and characterization of a novel gene disrupted by a pericentric inversion inv(4)(p13.1q21.1) in a family with cleft lip

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Isolation of Rat Liver Hepatocytes

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Short-Termin VivoInhibition of Insulin Receptor Substrate-1 Expression Leads to Insulin Resistance, Hyperinsulinemia, and Increased Adiposity

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PTP1B antisense-treated mice show regulation of genes involved in lipogenesis in liver and fat

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Very-low-density-lipoprotein secretion by isolated hepatocytes of fat-fed rats

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The effect of tryptophan administration on fatty acid synthesis in the liver of the fasted normal rat

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