Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

Role of AMP-activated protein kinase in mechanism of metformin action

2001 • 5,086 citations

Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

2002 • 2,024 citations

Loss of stearoyl–CoA desaturase-1 function protects mice against adiposity

2002 • 1,066 citations

Phospholipid synthesis in a membrane fraction associated with mitochondria.

1990 • 1,051 citations

Continuous Fatty Acid Oxidation and Reduced Fat Storage in Mice Lacking Acetyl-CoA Carboxylase 2

2001 • 880 citations

Management of cellular energy by the AMP‐activated protein kinase system

2003 • 851 citations

Role for Stearoyl-CoA Desaturase-1 in Leptin-Mediated Weight Loss

2002 • 825 citations

Fatty acid import into mitochondria

2000 • 753 citations

Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol

1999 • 737 citations

Malonyl-CoA, fuel sensing, and insulin resistance

1999 • 655 citations

High Rates of Fatty Acid Oxidation during Reperfusion of Ischemic Hearts Are Associated with a Decrease in Malonyl-CoA Levels Due to an Increase in 5’-AMP-activated Protein Kinase Inhibition of Acetyl-CoA Carboxylase

1995 • 582 citations

Mechanism of rat liver microsomal stearyl-CoA desaturase. Studies of the substrate specificity, enzyme-substrate interactions, and the function of lipid.

1976 • 552 citations

AMP-activated protein kinase, super metabolic regulator

2003 • 457 citations

The Biosynthesis of Hepatic Cholesterol Esters and Triglycerides Is Impaired in Mice with a Disruption of the Gene for Stearoyl-CoA Desaturase 1

2000 • 446 citations

Mitochondrial and peroxisomal fatty acid oxidation in liver homogenates and isolated hepatocytes from control and clofibrate-treated rats.

1979 • 436 citations

Characterization of the Role of AMP-Activated Protein Kinase in the Regulation of Glucose-Activated Gene Expression Using Constitutively Active and Dominant Negative Forms of the Kinase

2000 • 410 citations

Mechanism for Fatty Acid “Sparing” Effect on Glucose-induced Transcription

2002 • 395 citations

AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target

1999 • 394 citations

Yeast SNF1 is functionally related to mammalian AMP-activated protein kinase and regulates acetyl-CoA carboxylase in vivo.

1994 • 388 citations

REGULATION OF MAMMALIAN ACETYL-COENZYME A CARBOXYLASE

1997 • 381 citations

Coordinate Regulation of Malonyl-CoA Decarboxylase,sn-Glycerol-3-phosphate Acyltransferase, and Acetyl-CoA Carboxylase by AMP-activated Protein Kinase in Rat Tissues in Response to Exercise

2002 • 369 citations

Regulation of HMG-CoA reductase: identification of the site phosphorylated by the AMP-activated protein kinase in vitro and in intact rat liver.

1990 • 301 citations

The α1 and α2 isoforms of the AMP‐activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitro

1996 • 260 citations

C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity

2002 • 257 citations

The effect of fasting on the activity of liver carnitine palmitoyltransferase and its inhibition by malonyl-CoA

1981 • 250 citations

Targeted Disruption of Stearoyl-CoA Desaturase1 Gene in Mice Causes Atrophy of Sebaceous and Meibomian Glands and Depletion of Wax Esters in the Eyelid

2001 • 249 citations

Rapid transformation of white adipocytes into fat-oxidizing machines

2004 • 231 citations

Insulin activation of acetyl-CoA carboxylase accompanied by inhibition of the 5'-AMP-activated protein kinase.

1992 • 221 citations

Regulation of Transcription by AMP-activated Protein Kinase

2001 • 198 citations

Regulation of spinach SNF1‐related (SnRK1) kinases by protein kinases and phosphatases is associated with phosphorylation of the T loop and is regulated by 5′‐AMP

1999 • 193 citations

Hepatic malonyl-CoA levels of fed, fasted and diabetic rats as measured using a simple radioisotopic assay.

1978 • 193 citations

Regulation of fatty acid and cholesterol metabolism by the AMP-activated protein kinase

1992 • 188 citations

Regulation of fatty acid synthesis via phosphorylation of acetyl-CoA carboxylase

1989 • 186 citations

Stearoyl-CoA desaturase 1 deficiency elevates insulin-signaling components and down-regulates protein-tyrosine phosphatase 1B in muscle

2003 • 182 citations

Leptin Activates Cardiac Fatty Acid Oxidation Independent of Changes in the AMP-activated Protein Kinase-Acetyl-CoA Carboxylase-Malonyl-CoA Axis

2002 • 179 citations

Diurnal rhythm of phosphorylation of rat liver acetyl – CoA carboxylase by the AMP‐activated protein kinase, demonstrated using freeze‐clamping

1992 • 172 citations

The Role of Stearoyl-CoA Desaturase in Body Weight Regulation

2004 • 120 citations

Insulin stimulates the dephosphorylation and activation of acetyl-CoA carboxylase.

1988 • 104 citations

Activation of AMPK is essential for AICAR-induced glucose uptake by skeletal muscle but not adipocytes

2002 • 93 citations

Liver AMP-activated protein kinase and acetyl-CoA carboxylase during and after exercise

1999 • 85 citations

Hepatic fatty acid oxidation and ketogenesis after clofibrate treatment

1978 • 81 citations

Development and characterization of a polyclonal antibody against rat liver mitochondrial overt carnitine palmitoyltransferase (CPT I). Distinction of CPT I from CPT II and of isoforms of CPT I in different tissues

1992 • 69 citations

AMP-activated protein kinase and hepatic genes involved in glucose metabolism

2003 • 49 citations

Activation of hepatic acetyl-CoA carboxylase by glutamate and Mg2+ is mediated by protein phosphatase-2A

1996 • 47 citations

Evidence that the AMP‐activated protein kinase stimulates rat liver carnitine palmitoyltransferase I by phosphorylating cytoskeletal components

1998 • 43 citations

Pro-EMAP II is not primarily cleaved by caspase-3 and -7

2002 • 29 citations