Dissociation ofras oncogene-induced gene expression and anchorage-independent growth in a series of somatic cell mutants

ras GENES

1987 • 3,818 citations

Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation

1991 • 2,774 citations

The mitogen-activated protein kinase signal transduction pathway

1993 • 2,174 citations

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1990 • 2,129 citations

Mammalian Ras interacts directly with the serine/threonine kinase raf

1993 • 1,983 citations

Proteins regulating Ras and its relatives

1993 • 1,930 citations

Phosphatidylinositol-3-OH kinase direct target of Ras

1994 • 1,923 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1995 • 1,499 citations

Signal transduction via the MAP kinases: proceed at your own RSK.

1993 • 1,262 citations

FUNCTION AND REGULATION OF RAS

1993 • 1,161 citations

PRIMARY RESPONSE GENES INDUCED BY GROWTH FACTORS AND TUMOR PROMOTERS

1991 • 1,078 citations

MAP kinase kinase kinase, MAP kinase kinase and MAP kinase

1994 • 1,005 citations

Complexes of Ras⋅GTP with Raf-1 and Mitogen-Activated Protein Kinase Kinase

1993 • 987 citations

An essential role for Rac in Ras transformation

1995 • 895 citations

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

1993 • 876 citations

Cellular tumorigenicity in nude mice: Correlation with cell growth in semi-solid medium

1974 • 814 citations

Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro

1993 • 730 citations

Multiple ras functions can contribute to mammalian cell transformation

1995 • 658 citations

Ras-Dependent Induction of Cellular Responses by Constitutively Active Phosphatidylinositol-3 Kinase

1995 • 553 citations

Guanosine Triphosphatase Activating Protein (GAP) Interacts with the p21 ras Effector Binding Domain

1988 • 533 citations

Fos and Jun bind cooperatively to the AP-1 site: reconstitution in vitro.

1988 • 511 citations

Overproduction of protein kinase C causesdisordered growth control in rat fibroblasts

1988 • 492 citations

Epidermal growth factor and oncogenes induce transcription of the same cellular mRNA in rat fibroblasts.

1985 • 344 citations

Cooperative interaction of S. pombe proteins required for mating and morphogenesis

1994 • 303 citations

Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator.

1994 • 281 citations

Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap.

1994 • 270 citations

ralGDS family members interact with the effector loop of ras p21.

1994 • 260 citations

Correlation of anchorage-independent growth with tumorigenicity of chemically transformed mouse epidermal cells.

1978 • 243 citations

Induction of metallothionein and other mRNA species by carcinogens and tumor promoters in primary human skin fibroblasts.

1986 • 215 citations

Two dominant-acting selectable markers for gene transfer studies in mammalian cells.

1988 • 184 citations

A Human Protein Selected for Interference with Ras Function Interacts Directly with Ras and Competes with Raf1

1995 • 170 citations

Nucleotide sequence of murine ornithine decarboxylase mRNA.

1985 • 164 citations

Cloning and characterization of a mouse cysteine proteinase.

1986 • 137 citations

GTPase-Activating Protein SH2-SH3 Domains Induce Gene Expression in a Ras-Dependent Fashion

1992 • 101 citations

Identification of a novel growth factor-responsive gene in vascular smooth muscle cells.

1994 • 83 citations

GTPase-activating protein SH2-SH3 domains induce gene expression in a Ras-dependent fashion.

1992 • 81 citations

A cell cycle and mutational analysis of anchorage-independent growth: cell adhesion and TGF-beta 1 control G1/S transit specifically

1993 • 70 citations

Disturbances in growth control and gene expression in a C3H/10T1/2 cell line that stably overproduces protein kinase C.

1989 • 64 citations

Non-nuclear oncogenes and the regulation of gene expression in transformed cells.

1993 • 42 citations

A Factor Present in Fetal Calf Serum Enhances Oncogene-Induced Transformation of Rodent Fibroblasts

1987 • 22 citations

Novel revertants of H-ras oncogene-transformed R6-PKC3 cells.

1992 • 18 citations

A factor present in fetal calf serum enhances oncogene-induced transformation of rodent fibroblasts.

1987 • 12 citations

Transformation-restoring factor: a low molecular weight secreted factor required for anchorage-independent growth of oncogene-resistant mutant cell lines.

1995 • 5 citations

A novel, plasmid-based system for studying gene rearrangements in mammalian cells.

1991 • 5 citations