A mutational analysis of the 5′ HoxD genes: dissection of genetic interactions during limb development in the mouse

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

1987 • 2,368 citations

Altering the Genome by Homologous Recombination

1989 • 2,021 citations

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

1988 • 1,690 citations

Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud

1994 • 801 citations

Dorsalizing signal Wnt-7a required for normal polarity of D–V and A–P axes of mouse limb

1995 • 719 citations

FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb

1993 • 660 citations

Coordinate expression of the murine Hox-5 complex homoeobox-containing genes during limb pattern formation

1989 • 612 citations

A Morphogenetic Approach to the Origin and Basic Organization of the Tetrapod Limb

1986 • 604 citations

Absence of radius and ulna in mice lacking hoxa-11 andhoxd-11

1995 • 587 citations

Fibroblast growth factors induce additional limb development from the flank of chick embryos

1995 • 578 citations

Multiple developmental defects in Engrailed-1 mutant mice: an early mid-hindbrain deletion and patterning defects in forelimbs and sternum

1994 • 509 citations

FGF-2: Apical Ectodermal Ridge Growth Signal for Chick Limb Development

1994 • 470 citations

Disruption of the Hoxd-13 gene induces localized heterochrony leading to mice with neotenic limbs

1993 • 454 citations

Guidebook to the homeobox genes

1994 • 399 citations

Murine genes related to the Drosophila AbdB homeotic genes are sequentially expressed during development of the posterior part of the body.

1991 • 344 citations

Interaction between the signaling molecules WNT7a and SHH during vertebrate limb development: Dorsal signals regulate anteroposterior patterning

1995 • 318 citations

HOX-4 genes and the morphogenesis of mammalian genitalia.

1991 • 292 citations

Genetic interaction between hoxb-5 and hoxb-6 is revealed by nonallelic noncomplementation.

1995 • 268 citations

Homeotic transformations and limb defects in Hox A11 mutant mice.

1993 • 260 citations

The development of the vertebrate limb

1980 • 254 citations

Axial homeosis and appendicular skeleton defects in mice with a targeted disruption of hoxd-11

1994 • 253 citations

Mice with targeted disruptions in the paralogous genes hoxa-3 and hoxd-3 reveal synergistic interactions

1994 • 245 citations

EVOLUTION AND MORPHOGENETIC RULES: THE SHAPE OF THE VERTEBRATE LIMB IN ONTOGENY AND PHYLOGENY

1988 • 239 citations

EVOLUTION OF HOX GENES

1994 • 237 citations

Compound mutants for the paralogous hoxa-4, hoxb-4, and hoxd-4 genes show more complete homeotic transformations and a dose-dependent increase in the number of vertebrae transformed.

1995 • 228 citations

Mice deficient in cellular retinoic acid binding protein II (CRABPII) or in both CRABPI and CRABPII are essentially normal

1995 • 228 citations

Misexpression of Hoxa-13 induces cartilage homeotic transformation and changes cell adhesiveness in chick limb buds.

1995 • 205 citations

Vertebrate Limb Development

1994 • 204 citations

The vertebrate limb: A model system to study the Hox/hom gene network during development and evolution

1992 • 175 citations

The initiation of the limb bud: Growth factors, Hox genes, and retinoids

1995 • 170 citations

Guidebook to the Hoineobox Genes

1994 • 161 citations

High-fidelity gene targeting in embryonic stem cells by using sequence replacement vectors.

1992 • 141 citations

Vertebrate Hox genes and proliferation: an alternative pathway to homeosis?

1995 • 141 citations

Evolution and Morphogenetic Rules: The Shape of the Vertebrate Limb in Ontogeny and Phylogeny

1988 • 139 citations

The Hox-4.8 gene is localized at the 5′ extremity of the Hox-4 complex and is expressed in the most posterior parts of the body during development

1991 • 135 citations

Axial skeleton homeosis and forelimb malformations in Hoxd-11 mutant mice.

1995 • 107 citations

Homeobox genes and pattern formation in the vertebrate limb

1992 • 103 citations

Location of crossovers during gene targeting with insertion and replacement vectors.

1993 • 91 citations

Ectoderm as a determinant of early tissue pattern in the limb bud

1984 • 83 citations

Limb Development and Regeneration

1993 • 78 citations

Postaxial polydactyly in forelimbs of CRABP-II mutant mice.

1995 • 72 citations

Evolutionary Transformation of Limb Pattern: Heterochrony and Secondary Fusion

1991 • 42 citations

Evolutionary developmental biology of the tetrapod limb

1994 • 31 citations

Spontaneous and retinoic acid‐induced postaxial polydactyly in mice

1985 • 30 citations

The Interdigital Spaces of the Chick Leg Bud as a Model for Analysing Limb Morphogenesis and Cell Differentiation

1991 • 29 citations

Developmental Approaches to the Problem of Transformation of Limb Structure in Evolution

1991 • 26 citations

Location of Crossovers during Gene Targeting with Insertion and Replacement Vectors

1993 • 18 citations

Lessons from extra digits.

1993 • 4 citations