Alternate antiestrogens and approaches to the prevention of breast cancer

Effects of Tamoxifen on Bone Mineral Density in Postmenopausal Women with Breast Cancer

1992 • 1,139 citations

ADJUVANT TAMOXIFEN IN EARLY BREAST CANCER: OCCURRENCE OF NEW PRIMARY CANCERS

1989 • 932 citations

Raloxifene (LY139481 HCI) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized rats.

1994 • 614 citations

Risk of endometrial cancer after tamoxifen treatment of breast cancer

1994 • 574 citations

A MONOHYDROXYLATED METABOLITE OF TAMOXIFEN WITH POTENT ANTIOESTROGENIC ACTIVITY

1977 • 502 citations

Development of antiestrogens and their use in breast cancer: eighth Cain memorial award lecture.

1990 • 419 citations

Tamoxifen and metabolites in MCF7 cells: correlation between binding to estrogen receptor and inhibition of cell growth.

1982 • 393 citations

Potential Role of Tamoxifen in Prevention of Breast Cancer

1991 • 387 citations

Fatal myocardial infarction in the Scottish adjuvant tamoxifen trial. The Scottish Breast Cancer Committee.

1991 • 367 citations

Antitumor actions of keoxifene and tamoxifen in the N-nitrosomethylurea-induced rat mammary carcinoma model.

1987 • 355 citations

High-grade endometrial carcinoma in tamoxifen-treated breast cancer patients.

1993 • 347 citations

Effects of anti-estrogens on bone in castrated and intact female rats

1987 • 329 citations

Two-year carcinogenicity study of tamoxifen in Alderley Park Wistar-derived rats.

1993 • 304 citations

A current view of tamoxifen for the treatment and prevention of breast cancer

1993 • 297 citations

Major difference in the hepatocarcinogenicity and DNA adduct forming ability between toremifene and tamoxifen in female Crl:CD(BR) rats.

1993 • 268 citations

Antagonism of estrogen action with a new benzothiophene derived antiestrogen

1983 • 244 citations

Genotoxic potential of tamoxifen and analogues in female Fischer F344/n rats, DBA/2 and C57BL/6 mice and in human MCL-5 cells

1992 • 239 citations

The triphenylethylene drug tamoxifen is a strong liver carcinogen in the rat

1993 • 235 citations

Acquired Tamoxifen Resistance: Correlation With Reduced Breast Tumor Levels of Tamoxifen and Isomerization of Trans-4-Hydroxytamoxifen

1991 • 233 citations

Evaluation of the antitumour activity of the non-steroidal antioestrogen monohydroxytamoxifen in the DMBA-induced rat mammary carcinoma model

1980 • 212 citations

Tamoxifen and bone metabolism in postmenopausal low-risk breast cancer patients: a randomized study.

1994 • 199 citations

Non-linearity of neoplastic conversion induced in rat liver by low exposures to diethylnitrosamine

1993 • 148 citations

Estradiol-stimulated growth of MCF-7 tumors implanted in athymic mice: A model to study the tumoristatic action of tamoxifen

1988 • 147 citations

Tamoxifen and the isomers of 4-hydroxytamoxifen in tamoxifen-resistant tumors from breast cancer patients.

1992 • 144 citations

An estrogen receptor model to describe the regulation of prolactin synthesis by antiestrogens in vitro.

1983 • 131 citations

The importance of tamoxifen metabolism in tamoxifen-stimulated breast tumor growth

1994 • 129 citations

Tamoxifen induces hepatocellular carcinoma in rat liver: A 1-year study with two antiestrogens

1993 • 127 citations

Tamoxifen reduces bone turnover and prevents lumbar spine and proximal femoral bone loss in early postmenopausal women

1993 • 126 citations

Nonsteroidal antiestrogens: Their biological effects and potential mechanisms of action

1978 • 123 citations

Multicenter phase II efficacy trial of toremifene in tamoxifen-refractory patients with advanced breast cancer.

1993 • 113 citations

EVIDENCE FOR THE METABOLIC ACTIVATION OF NON‐STEROIDAL ANTIOESTROGENS: A STUDY OF STRUCTURE‐ACTIVITY RELATIONSHIPS

1980 • 107 citations

Toremifene, a new antiestrogenic compound, for treatment of advanced breast cancer. Phase II study

1988 • 100 citations

Toremifene and tamoxifen in advanced breast cancer - a double-blind cross-over trial

1993 • 98 citations

Investigation of the Mechanism of Tamoxifen-Stimulated Breast Tumor Growth With Nonisomerizable Analogues of Tamoxifen and Metabolites

1993 • 92 citations

Long-term tamoxifen treatment for breast cancer

1994 • 90 citations

Identification of estrogenic tamoxifen metabolite(s) in tamoxifen-resistant human breast tumors.

1992 • 87 citations

Pyrrolidino-4-iodotamoxifen and 4-iodotamoxifen, new analogues of the antiestrogen tamoxifen for the treatment of breast cancer.

1991 • 83 citations

Pharmacologic and Biologic Properties of Droloxifene, A New Antiestrogen

1991 • 72 citations

In vivo and in vitro antiestrogenic action of 3-hydroxytamoxifen, tamoxifen and 4-hydroxytamoxifen

1985 • 60 citations

Droloxifene, a new anti-oestrogen in postmenopausal advanced breast cancer: Preliminary results of a double-blind dose-finding phase II trial

1992 • 58 citations

Pharmacokinetics of Droloxifene and Its Metabolites in Breast Cancer Patients

1991 • 47 citations

Epidemiologic data on exogenous hormones and hepatocellular carcinoma and selected other cancers

1991 • 44 citations

What do we know and what don't we know about tamoxifen in the human uterus

1994 • 44 citations

TAT-59, a new triphenylethylene derivative with antitumor activity against hormone-dependent tumors

1990 • 39 citations

Phase I trail of droloxifene in patients with metastatic breast cancer

1994 • 28 citations

Toremifene, a new antiestrogenic compound in the treatment of metastatic mammary cancer. A phase II study

1990 • 20 citations

Mitotic rate, DNA distribution, and chromatinin situ sensitivity to heparin in breast cancer

1990 • 8 citations

Toremifene: Clinical Phase II/III Trials of a New Antiestrogen in Patients with Advanced Breast Cancer

1989 • 6 citations