Autoantibody Recognition of COOH-Terminal Epitopes of GAD65 Marks the Risk for Insulin Requirement in Adult-Onset Diabetes Mellitus¹

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

1993 • 1,087 citations

Insulin Antibodies in Insulin-Dependent Diabetics Before Insulin Treatment

1983 • 1,078 citations

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice

1993 • 962 citations

Prediction of Type I Diabetes in First-Degree Relatives Using a Combination of Insulin, GAD, and ICA512bdc/IA-2 Autoantibodies

1996 • 788 citations

UKPDS 25: autoantibodies to islet-cell cytoplasm and glutamic acid decarboxylase for prediction of insulin requirement in type 2 diabetes

1997 • 770 citations

Autoantibodies to GABA-ergic Neurons and Pancreatic Beta Cells in Stiff-Man Syndrome

1990 • 618 citations

Textbook of Diabetes

1991 • 586 citations

Antibodies to Glutamic Acid Decarboxylase Reveal Latent Autoimmune Diabetes Mellitus in Adults With a Non—Insulin-Dependent Onset of Disease

1993 • 548 citations

Clinical and genetic characteristics of type 2 diabetes with and without GAD antibodies.

1999 • 505 citations

Combined use of autoantibodies (IA-2 autoantibody, GAD autoantibody, insulin autoantibody, cytoplasmic islet cell antibodies) in type 1 diabetes: Combinatorial Islet Autoantibody Workshop.

1998 • 424 citations

Latent Autoimmune Diabetes Mellitus in Adults (LADA): the Role of Antibodies to Glutamic Acid Decarboxylase in Diagnosis and Prediction of Insulin Dependency

1994 • 420 citations

A novel radioligand binding assay to determine diagnostic accuracy of isoform-specific glutamic acid decarboxylase antibodies in childhood IDDM

1994 • 402 citations

Cloning and primary structure of a human islet isoform of glutamic acid decarboxylase from chromosome 10.

1991 • 281 citations

Immunogenetic and Clinical Characterization of Slowly Progressive IDDM

1993 • 251 citations

Control of Autoimmune Diabetes in NOD Mice by GAD Expression or Suppression in β Cells

1999 • 248 citations

Immunology of Insulin-Dependent Diabetes Mellitus

1985 • 240 citations

Quantitative assay using recombinant human islet glutamic acid decarboxylase (GAD65) shows that 64K autoantibody positivity at onset predicts diabetes type.

1993 • 200 citations

Radioimmunoassays for glutamic acid decarboxylase (GAD65) and GAD65 autoantibodies using 35S or 3H recombinant human ligands

1995 • 194 citations

Concentration of Insulin Autoantibodies at Onset of Type I Diabetes: Inverse Log-Linear Correlation With Age

1988 • 185 citations

Autoreactive epitopes defined by diabetes-associated human monoclonal antibodies are localized in the middle and C-terminal domains of the smaller form of glutamate decarboxylase.

1993 • 172 citations

Identification of a dominant epitope of glutamic acid decarboxylase (GAD-65) recognized by autoantibodies in stiff-man syndrome.

1993 • 162 citations

GAD Antibodies in NIDDM: Ten-year follow-up from the diagnosis

1995 • 162 citations

GAD Autoantibodies in IDDM, Stiff-Man Syndrome, and Autoimmune Polyendocrine Syndrome Type I Recognize Different Epitopes

1994 • 160 citations

Immunological heterogeneity in Type I diabetes: presence of distinct autoantibody patterns in patients with acute onset and slowly progressive disease

1998 • 143 citations

Islet cell autoantigens in insulin-dependent diabetes.

1993 • 136 citations

Disease Sensitivity and Specificity of 52 Assays for Glutamic Acid Decarboxylase Antibodies: The Second International GADAB Workshop

1995 • 129 citations

High diagnostic sensitivity of glutamate decarboxylase autoantibodies in insulin-dependent diabetes mellitus with clinical onset between age 20 and 40 years. The Belgian Diabetes Registry.

1995 • 129 citations

Glutamic acid decarboxylase autoantibodies in stiff-man syndrome and insulin-dependent diabetes mellitus exhibit similarities and differences in epitope recognition.

1996 • 124 citations

Time Course of Islet Cell Antibodies and β-Cell Function in Non-Insulin-Dependent Stage of Type I Diabetes

1987 • 121 citations

Antibodies to glutamic acid decarboxylase and insulin-dependent diabetes in patients with autoimmune polyendocrine syndrome type I.

1996 • 120 citations

Cloning, characterization, and autoimmune recognition of rat islet glutamic acid decarboxylase in insulin-dependent diabetes mellitus.

1991 • 96 citations

High Level of Concordance Between Assays for Glutamic Acid Decarboxylase Antibodies: The First International Glutamic Acid Decarboxylase Antibody Workshop

1994 • 80 citations

Association of GAD-65, but not of GAD-67, with the Golgi complex of transfected Chinese hamster ovary cells mediated by the N-terminal region.

1993 • 79 citations

Diagnostic sensitivity of immunodominant epitopes of glutamic acid decarboxylase (GAD65) autoantibodies in childhood IDDM

1996 • 76 citations

Islet cell and glutamic acid decarboxylase antibodies present at diagnosis of diabetes predict the need for insulin treatment. A cohort study in young adults whose disease was initially labeled as type 2 or unclassifiable diabetes.

1999 • 73 citations

Radioimmunoassay Detects the Frequent Occurrence of Autoantibodies to the Mr 65,000 Isoform of Glutamic Acid Decarboxylase in Japanese Insulin-Dependent Diabetes

1994 • 66 citations

Identification of Glutamic Acid Decarboxylase Autoantibody Heterogeneity and Epitope Regions in Type I Diabetes

1994 • 63 citations

Two Distinct Glutamic Acid Decarboxylase Auto-Antibody Specificities in IDDM Target Different Epitopes

1995 • 60 citations

Glutamate decarboxylase antibody levels predict rate of β-cell decline in adult-onset diabetes

1995 • 57 citations

Islet cell and glutamic acid decarboxylase antibodies in hyperthyroid patients: at diagnosis and following treatment

1996 • 40 citations

Differential detection of rat islet and brain glutamic acid decarboxylase (GAD) isoforms with sequence-specific peptide antibodies.

1995 • 36 citations

Immunoglobulin variable gene analysis of human autoantibodies reveals antigen‐driven immune response to glutamate decarboxylase in type 1 diabetes mellitus

1995 • 29 citations

Glutamic acid decarboxylase (GAD) in insulin-dependent diabetes mellitus

1996 • 20 citations

A Monoclonal Antibody-Based Characterization of Autoantibodies against Glutamic Acid Decarboxylase in Adults with Latent Autoimmune Diabetes

1998 • 17 citations

Controversies on humoral immune markers of insulin-dependent diabetes mellitus.

1998 • 6 citations

Tyrosine phosphatase-like proteins as autoantigens in insulin-dependent diabetes mellitus: the targets for 37/40k antibodies

1996 • 4 citations